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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 2
1947 6
1948 5
1949 5
1950 9
1951 10
1952 7
1953 6
1954 7
1955 11
1956 11
1957 7
1958 5
1959 10
1960 11
1961 15
1962 8
1963 18
1964 39
1965 33
1966 36
1967 43
1968 48
1969 68
1970 79
1971 76
1972 122
1973 83
1974 85
1975 74
1976 80
1977 78
1978 71
1979 82
1980 84
1981 97
1982 153
1983 136
1984 149
1985 166
1986 145
1987 143
1988 198
1989 287
1990 266
1991 203
1992 244
1993 206
1994 224
1995 223
1996 216
1997 229
1998 203
1999 209
2000 255
2001 264
2002 264
2003 321
2004 396
2005 529
2006 548
2007 547
2008 576
2009 685
2010 697
2011 685
2012 720
2013 645
2014 632
2015 681
2016 696
2017 797
2018 711
2019 300
2020 8
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14,915 results
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Page 1
A new era for understanding amyloid structures and disease.
Iadanza MG, et al. Nat Rev Mol Cell Biol 2018 - Review. PMID 30237470 Free article.
The aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions is the hallmark of amyloid disease. ...The first near-atomic-resolution structures of amyloid fibrils formed in vitro, seeded from plaque material and analysed directly ex vivo are now available. ...
The aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions is the hallmark of …
Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee.
Benson MD, et al. Amyloid 2018. PMID 30614283
Given the more broad use of the word "amyloid" several classes of amyloid fibrils may be distinguished. For the medical in vivo situation, and to be included in the amyloid nomenclature list, "amyloid" still means mainly extracellular tissue deposits of protein fibrils, recognized by specific properties, such as green-yellow birefringence after staining with Congo red. It should also be underlined that in vivo amyloid fibrils, in addition to the main protein contain associated compounds, particularly serum amyloid P-component (SAP) and proteoglycans, mainly heparan sulfate proteoglycan. ...
Given the more broad use of the word "amyloid" several classes of amyloid fibrils may be distinguished. For the medical in viv …
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.
Vogler TO, et al. Nature 2018. PMID 30464263 Free PMC article.
Here we show that TDP-43 is an essential protein for normal skeletal muscle formation that unexpectedly forms cytoplasmic, amyloid-like oligomeric assemblies, which we call myo-granules, during regeneration of skeletal muscle in mice and humans. ...Although myo-granules occur during normal skeletal-muscle regeneration, myo-granules can seed TDP-43 amyloid fibrils in vitro and are increased in a mouse model of inclusion body myopathy. ...
Here we show that TDP-43 is an essential protein for normal skeletal muscle formation that unexpectedly forms cytoplasmic, amyloid-li …
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Parhizkar S, et al. Nat Neurosci 2019. PMID 30617257 Free PMC article.
Longitudinal amyloid small animal positron emission tomography demonstrates accelerated amyloidogenesis in Trem2 loss-of-function mutants at early stages, which progressed at a lower rate with aging. These findings suggest that in the absence of functional Trem2, early amyloidogenesis is accelerated due to reduced phagocytic clearance of amyloid seeds despite reduced plaque-associated ApoE....
Longitudinal amyloid small animal positron emission tomography demonstrates accelerated amyloidogenesis in Trem2 loss-of-function mut …
Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms.
Giorgetti S, et al. Int J Mol Sci 2018 - Review. PMID 30205618 Free PMC article.
Actually, it is well documented that the prevention of amyloid aggregation results in several cytoprotective effects. Here, we portray the state of the art in the field. ...
Actually, it is well documented that the prevention of amyloid aggregation results in several cytoprotective effects. Here, we portra …
Immunoglobulin light chain amyloid aggregation.
Blancas-Mejia LM, et al. Chem Commun (Camb) 2018 - Review. PMID 30087961 Free PMC article.
It is characterized by an abnormal proliferation of plasma cells (fully differentiated B cells) producing an excess of monoclonal immunoglobulin light chains that are secreted into circulation, where the light chains misfold, aggregate as amyloid fibrils in target organs, and cause organ dysfunction, organ failure, and death. ...Last, we will review our recent findings on the high resolution structure of AL amyloid fibrils. AL amyloidosis is the best example of protein sequence diversity in misfolding diseases, as each patient has a unique combination of germline donor sequences and multiple amino acid mutations in the protein that forms the amyloid fibril....
It is characterized by an abnormal proliferation of plasma cells (fully differentiated B cells) producing an excess of monoclonal immunoglob …
Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition
Martorell AJ, et al. Cell 2019. PMID 30879788 Free PMC article.
Seven days of auditory GENUS improved spatial and recognition memory and reduced amyloid in AC and hippocampus of 5XFAD mice. ...Whole brain analysis using SHIELD revealed widespread reduction of amyloid plaques throughout neocortex after multi-sensory GENUS. ...
Seven days of auditory GENUS improved spatial and recognition memory and reduced amyloid in AC and hippocampus of 5XFAD mice. ...Whol …
Plasma tau/amyloid-β1-42 ratio predicts brain tau deposition and neurodegeneration in Alzheimer's disease.
Park JC, et al. Brain 2019. PMID 30668647
We found significant correlations of plasma p-tau, t-tau, p-tau/amyloid-β1-42, and t-tau/amyloid-β1-42 with brain tau deposition in cross-sectional and longitudinal manners. ...Furthermore, the longitudinal changes in cerebral amyloid deposition, brain glucose metabolism, and hippocampal volume change were also highly associated with plasma t-tau/amyloid-β1-42. ...
We found significant correlations of plasma p-tau, t-tau, p-tau/amyloid-β1-42, and t-tau/amyloid-β1-42 with brain tau depositi …
Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia.
Rabinovici GD, et al. JAMA 2019 - Clinical Trial. PMID 30938796 Free PMC article.
IMPORTANCE: Amyloid positron emission tomography (PET) detects amyloid plaques in the brain, a core neuropathological feature of Alzheimer disease. ...DESIGN, SETTING, AND PARTICIPANTS: The Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) study was a single-group, multisite longitudinal study that assessed the association between amyloid PET and subsequent changes in clinical management for Medicare beneficiaries with MCI or dementia. ...
IMPORTANCE: Amyloid positron emission tomography (PET) detects amyloid plaques in the brain, a core neuropathological feature …
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