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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 25
1991 66
1992 71
1993 113
1994 143
1995 147
1996 177
1997 201
1998 222
1999 245
2000 325
2001 377
2002 480
2003 531
2004 544
2005 621
2006 680
2007 723
2008 897
2009 1172
2010 1224
2011 1170
2012 1363
2013 1427
2014 1460
2015 1616
2016 1557
2017 1645
2018 1660
2019 676
2020 6
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19,151 results
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[The Effect of Beta-Amyloid Peptides and Main Stress Protein HSP70 on Human SH-SY5Y Neuroblastoma Proteome].
Rezvykh AP, et al. Mol Biol (Mosk) 2018. PMID 30633251 Russian. Free article.
Here we describe the proteome of the neuroblastoma cell line after incubation with amyloid peptides Aβ42 and isomerized Asp7 (isoAβ42) without and with human recombinant heat shock protein 70 (HSP70). ...
Here we describe the proteome of the neuroblastoma cell line after incubation with amyloid peptides Aβ42 and isomerized Asp7 (isoAβ42 …
Clearance of beta-amyloid in the brain.
Ueno M, et al. Curr Med Chem 2014 - Review. PMID 25312211
As the supposed pathways of fluids seem to be critical for the maintenance of normal brain function, it is reasonable to suspect that an obstacle to the passage of fluids through these pathways likely induces some kinds of brain dysfunction such as Alzheimer's disease. ...In this review, these pathways for the clearance of fluids including Aβ from the brain into the blood are briefly reviewed and the relationship between dysfunction of these pathways and brain diseases is discussed....
As the supposed pathways of fluids seem to be critical for the maintenance of normal brain function, it is reasonable to suspect that …
Amyloid precursor protein processing and bioenergetics.
Wilkins HM and Swerdlow RH. Brain Res Bull 2017 - Review. PMID 27545490 Free PMC article.
The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. ...Existing data additionally indicate a relationship exists between mitochondria, bioenergetics, and APP processing. Here, we review data that address whether mitochondrial function and bioenergetics modify APP processing and Aβ production....
The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease …
The Role of NADPH Oxidases and Oxidative Stress in Neurodegenerative Disorders
Tarafdar A and Pula G. Int J Mol Sci 2018 - Review. PMID 30513656 Free PMC article.
Over the last decade, several more homologs have been identified and based on current research, the NOX family consists of NOX1, NOX2, NOX3, NOX4, NOX5, DUOX1 and DUOX2 enzymes. ...Elevated ROS leads to oxidative stress (OS), which has been associated with a myriad of inflammatory and degenerative pathologies. ...
Over the last decade, several more homologs have been identified and based on current research, the NOX family consists of NOX1, NOX2 …
Phases of A beta-deposition in the human brain and its relevance for the development of AD.
Thal DR, et al. Neurology 2002. PMID 12084879
BACKGROUND: The deposition of the amyloid beta protein (Abeta) is a histopathologic hallmark of AD. The regions of the medial temporal lobe (MTL) are hierarchically involved in Abeta-deposition. ...There are also indications that clinically proven AD cases with full-blown beta-amyloidosis may be preceded in early stages by nondemented cases exhibiting AD-related Abeta pathology....
BACKGROUND: The deposition of the amyloid beta protein (Abeta) is a histopathologic hallmark of AD. The regions of the medial …
The road to restoring neural circuits for the treatment of Alzheimer's disease
Canter RG, et al. Nature 2016 - Review. PMID 27830780
Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at reducing amyloid-have failed to reverse cognitive symptoms. These clinical findings suggest that cognitive decline is the result of a complex pathophysiology and that targeting amyloid-alone may not be sufficient to treat Alzheimer's disease. ...
Although genetic studies initially suggested a primary role for amyloid-in Alzheimer's disease, treatment strategies targeted at redu …
β-Amyloid Prions and the Pathobiology of Alzheimer's Disease.
Watts JC and Prusiner SB. Cold Spring Harb Perspect Med 2018 - Review. PMID 28193770 Free PMC article.
Aggregation of the β-amyloid (Aβ) peptide within the brain is thought to be an initiating event in AD pathogenesis. Many recent studies in transgenic mice have provided evidence that Aβ aggregates become self-propagating during disease, leading to a cascade of protein aggregation in the brain, which may underlie the progressive nature of AD. ...Here, we review the evidence that Aβ can become a prion during disease and discuss how Aβ prions may be important for understanding the pathobiology of AD....
Aggregation of the β-amyloid (Aβ) peptide within the brain is thought to be an initiating event in AD pathogenesis. Many recen …
In vivo Detection of Alzheimer's Disease
Leuzy A, et al. Yale J Biol Med 2018 - Review. PMID 30258316 Free PMC article.
The role of biological markers (biomarkers) of both the underlying molecular pathologies and related neurodegenerative changes has also been acknowledged. ...
The role of biological markers (biomarkers) of both the underlying molecular pathologies and related neurodegenerative changes has also b
Decreased clearance of CNS beta-amyloid in Alzheimer's disease.
Mawuenyega KG, et al. Science 2010. PMID 21148344 Free PMC article.
Alzheimer's disease is hypothesized to be caused by an imbalance between β-amyloid (Aβ) production and clearance that leads to Aβ accumulation in the central nervous system (CNS). ...However, there has not been direct evidence of altered Aβ production or clearance in Alzheimer's disease. By using metabolic labeling, we measured Aβ42 and Aβ40 production and clearance rates in the CNS of participants with Alzheimer's disease and cognitively normal controls. ...
Alzheimer's disease is hypothesized to be caused by an imbalance between β-amyloid (Aβ) production and clearance that l …
Sphingolipid-Enriched Extracellular Vesicles and Alzheimer's Disease: A Decade of Research
Dinkins MB, et al. J Alzheimers Dis 2017 - Review. PMID 27662306 Free PMC article.
Extracellular vesicles (EVs), particularly exosomes, have emerged in the last 10 years as a new player in the progression of Alzheimer's disease (AD) with high potential for being useful as a diagnostic and treatment tool. ...As ceramide is often elevated in AD, exosome secretion may be affected as well. Here, we review the available data showing that exosomes regulate the aggregation and clearance of amyloid-beta (Aβ) and discuss the differences in data from laboratories regarding Aβ binding, induction of aggregation, and glial clearance. ...
Extracellular vesicles (EVs), particularly exosomes, have emerged in the last 10 years as a new player in the progression of Alzheimer's dis …
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