Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1959 1
1961 2
1964 1
1965 1
1966 5
1967 2
1968 6
1969 3
1970 8
1971 8
1972 6
1973 6
1974 6
1975 2
1976 7
1977 4
1978 12
1979 10
1980 9
1981 10
1982 16
1983 11
1984 17
1985 12
1986 15
1987 21
1988 18
1989 26
1990 24
1991 18
1992 28
1993 24
1994 38
1995 55
1996 51
1997 44
1998 55
1999 43
2000 62
2001 62
2002 66
2003 74
2004 82
2005 94
2006 104
2007 83
2008 128
2009 140
2010 168
2011 163
2012 162
2013 183
2014 186
2015 181
2016 197
2017 208
2018 205
2019 72
2020 0
Text availability
Article attribute
Article type
Publication date

Search Results

2,915 results
Results by year
Filters applied: . Clear all
Page 1
Risk Factors and Emerging Therapies in Amyotrophic Lateral Sclerosis.
Nowicka N, et al. Int J Mol Sci 2019 - Review. PMID 31141951 Free PMC article.
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease characterized by a permanent degeneration of both upper and lower motor neurons. ...
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease characterized by a permanent degen
The multi-dimensional roles of astrocytes in ALS
Yamanaka K and Komine O. Neurosci Res 2018 - Review. PMID 29054467 Free article.
Despite significant progress in understanding the molecular and genetic aspects of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by the progressive loss of motor neurons, the precise and comprehensive pathomechanisms remain largely unknown. ...
Despite significant progress in understanding the molecular and genetic aspects of amyotrophic lateral sclerosis (ALS), …
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis.
Allen SP, et al. Brain 2019. PMID 30698736 Free PMC article.
As clinical evidence supports a negative impact of dysfunctional energy metabolism on the disease progression in amyotrophic lateral sclerosis, it is vital to understand how the energy metabolic pathways are altered and whether they can be restored to slow disease progression. ...To analyse the basis of the catabolic defect in amyotrophic lateral sclerosis we used a novel phenotypic metabolic array. We profiled fibroblasts and induced neuronal progenitor-derived human induced astrocytes from C9orf72 amyotrophic lateral sclerosis patients compared to normal controls, measuring the rates of production of reduced nicotinamide adenine dinucleotides from 91 potential energy substrates. ...
As clinical evidence supports a negative impact of dysfunctional energy metabolism on the disease progression in amyotrophic
Defective cholesterol metabolism in amyotrophic lateral sclerosis.
Abdel-Khalik J, et al. J Lipid Res 2017. PMID 27811233 Free PMC article.
As neurons die, cholesterol is released in the central nervous system (CNS); hence, this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS), in which altered cholesterol levels have been linked to prognosis. ...
As neurons die, cholesterol is released in the central nervous system (CNS); hence, this sterol and its metabolites may represent a biomarke …
Metabolic Reprogramming in Amyotrophic Lateral Sclerosis.
Szelechowski M, et al. Sci Rep 2018. PMID 29500423 Free PMC article.
Mitochondrial dysfunction in the spinal cord is a hallmark of amyotrophic lateral sclerosis (ALS), but the neurometabolic alterations during early stages of the disease remain unknown. ...
Mitochondrial dysfunction in the spinal cord is a hallmark of amyotrophic lateral sclerosis (ALS), but the neurometabol …
Role and Therapeutic Potential of Astrocytes in Amyotrophic Lateral Sclerosis.
Pehar M, et al. Curr Pharm Des 2017 - Review. PMID 28641533 Free PMC article.
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of motor neurons in the spinal cord, brain stem, and motor cortex. ...
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of motor neurons in the spinal cor
Interplay between spinal cord and cerebral cortex metabolism in amyotrophic lateral sclerosis.
Marini C, et al. Brain 2018. PMID 30730551 Free PMC article.
We recently reported the potential of Hough transform in delineating spinal cord metabolism by 18F-fluorodeoxyglucose PET/CT scanning in amyotrophic lateral sclerosis. The present study aimed to verify the relationship between spinal cord and brain metabolism in 44 prospectively recruited patients affected by amyotrophic lateral sclerosis submitted to 18F-fluorodeoxyglucose brain and whole-body PET/CT. ...
We recently reported the potential of Hough transform in delineating spinal cord metabolism by 18F-fluorodeoxyglucose PET/CT scanning …
SOD1 in Amyotrophic Lateral Sclerosis: "Ambivalent" Behavior Connected to the Disease.
Pansarasa O, et al. Int J Mol Sci 2018 - Review. PMID 29751510 Free PMC article.
In 1993, Rosen and collaborators discovered that the gene encoding SOD1 has mutations in amyotrophic lateral sclerosis (ALS) patients; moreover, these mutations are found in the exon regions, suggesting that their toxic effects are the consequence of protein dysfunction with an increase of oxidative stress. ...
In 1993, Rosen and collaborators discovered that the gene encoding SOD1 has mutations in amyotrophic lateral sclerosis
Energy metabolism in amyotrophic lateral sclerosis.
Dupuis L, et al. Lancet Neurol 2011 - Review. PMID 21035400
Amyotrophic lateral sclerosis (ALS) is characterised by the progressive degeneration of upper and lower motor neurons. Besides motor neuron degeneration, ALS is associated with several defects in energy metabolism, including weight loss, hypermetabolism, and hyperlipidaemia. ...Altogether, these results have clinical consequences for the management of defective energy metabolism in patients with ALS and pave the way for future therapeutic interventions....
Amyotrophic lateral sclerosis (ALS) is characterised by the progressive degeneration of upper and lower motor neurons.
Concise Review: The Cellular Conspiracy of Amyotrophic Lateral Sclerosis.
Serio A and Patani R. Stem Cells 2018 - Review. PMID 29235200 Free article.
Amyotrophic lateral sclerosis (ALS) is incurable and devastating. A dearth of therapies has galvanized experimental focus onto the cellular and molecular mechanisms that both initiate and subsequently drive motor neuron degeneration. ...
Amyotrophic lateral sclerosis (ALS) is incurable and devastating. A dearth of therapies has galvanized experimental foc
2,915 results
Jump to page
Feedback