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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1974 1
1981 3
1984 1
1987 48
1988 105
1989 118
1990 122
1991 105
1992 68
1993 85
1994 83
1995 84
1996 81
1997 81
1998 85
1999 80
2000 69
2001 75
2002 70
2003 72
2004 74
2005 56
2006 81
2007 75
2008 46
2009 61
2010 65
2011 80
2012 83
2013 67
2014 83
2015 116
2016 94
2017 92
2018 84
2019 43
2020 1
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2,474 results
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Page 1
Furosemide (frusemide). A pharmacokinetic/pharmacodynamic review (Part I)
Ponto LL and Schoenwald RD. Clin Pharmacokinet 1990 - Review. PMID 2185908
Comparisons between the observed diuresis/saluresis and plasma furosemide concentrations, urinary excretion rates and renal clearance found either negative or no correlations with plasma drug concentration but significant correlations with urine measurements. Response is related to the concentration of the drug in urine rather than in plasma. The most common adverse reactions attributable to furosemide therapy are essentially extensions of the therapeutic effects (i.e. fluid and electrolyte disturbances). ...
Comparisons between the observed diuresis/saluresis and plasma furosemide concentrations, urinary excretion rates and renal cl
Comparative Pharmacokinetics of High and Low Doses of the Herbicide Propanil in Mice.
Schafer R, et al. Chem Res Toxicol 2018. PMID 30230318 Free PMC article.
Laboratory studies on environmental contaminants are the most meaningful when these studies are conducted using concentrations that approximate levels in the environment. Many techniques to measure the distribution and pharmacokinetics (PK) on compounds rely on techniques, such as liquid scintillation counting (LSC) of radio-labeled starting compound, that require concentrations higher than environmental levels. ...
Laboratory studies on environmental contaminants are the most meaningful when these studies are conducted using concentrati
[Encainide]
Maggioni AP and Volpi A. Medicina (Firenze) 1988 - Review. PMID 3147354 Italian.
Ropivacaine Wound Infiltration for Pain Management After Breast Cancer Mastectomy: A Population Pharmacokinetic Analysis
Riff C, et al. Clin Pharmacol Drug Dev 2018 - Clinical Trial. Among authors: Cohen M. PMID 29659182
A 1-compartment disposition model with an absorption compartment and a transit compartment for the infusion best describes the data (67 observations from 10 women). ...This popPK model describes the pharmacokinetics of ropivacaine during continuous wound infusion and confirms the safety profile of the present technique....
A 1-compartment disposition model with an absorption compartment and a transit compartment for the infusion best descri …
Biotransformation of 2,4-toluenediamine in human skin and reconstructed tissues
Grohmann L, et al. Arch Toxicol 2017. PMID 28337504
Reconstructed human epidermis (RHE) is used for risk assessment of chemicals and cosmetics and RHE as well as reconstructed human full-thickness skin (RHS) become important for e.g., the pre-clinical development of drugs. ...The biotransformation of the aromatic amine 2,4-toluenediamine (2,4-TDA) has been compared in two commercially available RHS to normal human skin ex vivo, and in primary epidermal keratinocytes and dermal fibroblasts as well as in vitro generated epidermal Langerhans cells and dermal dendritic cells. ...
Reconstructed human epidermis (RHE) is used for risk assessment of chemicals and cosmetics and RHE as well as reconstructed human ful …
Study on enhanced lymphatic tracing of isosulfan blue injection by influence of osmotic pressure on lymphatic exposure
Ye T, et al. Drug Dev Ind Pharm 2018. PMID 29141490
Furthermore, pharmacokinetics of lymphatic drainage, lymph node uptake, and plasma concentration was investigate to explore the improving law of the lymphatic tracing by osmotic pressure, and combined with tissue irritation to determine the optimal osmotic pressure. ...The results showed that increasing osmotic pressure could significantly reduce injection site retention and increase IB concentration of lymph node. ...
Furthermore, pharmacokinetics of lymphatic drainage, lymph node uptake, and plasma concentration was investigate to explore the impro …
Glucosamine-paracetamol spray-dried solid dispersions with maximized intrinsic dissolution rate, bioavailability and decreased levels of in vivo toxic metabolites
Ali AMA, et al. Drug Des Devel Ther 2018. PMID 30275684 Free PMC article.
RESULTS: Instant water solubility and more than 7-fold increase in dissolution rate led to significantly high plasma drug concentration (>6.5-fold) compared to paracetamol alone. ...Lower number and concentration followed by the complete disappearance of toxic pathway metabolites were observed on second and third days of dosing with solid dispersions and physical mixtures, respectively. ...
RESULTS: Instant water solubility and more than 7-fold increase in dissolution rate led to significantly high plasma drug concentration
Pharmacokinetics of paracetamol in patients with chronic pancreatitis
Siepsiak M, et al. Pharmacol Rep 2016. PMID 27127912
The plasma concentrations of paracetamol and its metabolite (glucuronide) were measured with the validated high-pressure liquid chromatography (HPLC) method with ultraviolet (UV) detection. ...CONCLUSIONS: The research findings revealed that patients with chronic pancreatitis had lower concentrations of paracetamol. ...
The plasma concentrations of paracetamol and its metabolite (glucuronide) were measured with the validated high-pressure liquid chrom …
2,474 results
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