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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1797 2
1799 2
1801 2
1802 1
1803 2
1804 4
1809 2
1810 2
1811 4
1814 2
1816 2
1817 2
1819 1
1820 2
1823 2
1824 1
1827 1
1828 2
1829 1
1830 3
1831 2
1834 2
1835 1
1836 3
1837 3
1838 3
1839 4
1840 5
1841 1
1842 9
1843 4
1844 5
1845 7
1846 5
1847 6
1848 3
1849 3
1850 1
1851 3
1852 7
1853 3
1854 6
1855 3
1856 3
1857 5
1858 2
1859 2
1860 3
1861 3
1862 1
1863 1
1864 4
1866 4
1867 3
1868 6
1869 7
1870 3
1871 2
1872 10
1873 5
1874 9
1875 6
1876 4
1877 4
1878 2
1879 3
1880 6
1881 12
1882 20
1883 8
1884 14
1885 8
1886 9
1887 7
1888 3
1889 13
1890 19
1891 21
1892 19
1893 15
1894 4
1895 9
1896 9
1897 14
1898 18
1899 11
1900 27
1901 16
1902 9
1903 14
1904 17
1905 23
1906 14
1907 19
1908 26
1909 28
1910 19
1911 34
1912 35
1913 36
1914 30
1915 50
1916 45
1917 44
1918 41
1919 35
1920 36
1921 48
1922 50
1923 55
1924 59
1925 69
1926 66
1927 72
1928 69
1929 59
1930 70
1931 73
1932 59
1933 51
1934 61
1935 74
1936 81
1937 67
1938 75
1939 64
1940 70
1941 71
1942 50
1943 63
1944 55
1945 1453
1946 4970
1947 6031
1948 5254
1949 4712
1950 7420
1951 8699
1952 8622
1953 9434
1954 9927
1955 10084
1956 10574
1957 11251
1958 11470
1959 12115
1960 12843
1961 14017
1962 14716
1963 19466
1964 25220
1965 34656
1966 42831
1967 47944
1968 52635
1969 57555
1970 58464
1971 62452
1972 66631
1973 69203
1974 71495
1975 74595
1976 73154
1977 74230
1978 76984
1979 80528
1980 83433
1981 84606
1982 87889
1983 91049
1984 94696
1985 97549
1986 101484
1987 104327
1988 109041
1989 114677
1990 118790
1991 120292
1992 121506
1993 123683
1994 128682
1995 131066
1996 132527
1997 134901
1998 138997
1999 141882
2000 150664
2001 155006
2002 160510
2003 169014
2004 181405
2005 195166
2006 209538
2007 217476
2008 226587
2009 235628
2010 249140
2011 261513
2012 274678
2013 284797
2014 288757
2015 292120
2016 288173
2017 287705
2018 292641
2019 299382
2020 312209
2021 310669
2022 272021
2023 254587
2024 206066
2025 272

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8,827,144 results

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Quoted phrases not found in phrase index: "Cell Membrane Genetics Metabolism Pathology", "Glutamic Acid Genetics Metabolism Pharmacology", "Mitochondrial Drug Effects Genetics", "Mitochondria Genetics Metabolism Pathology", "Mitochondrial Membranes Metabolism Pathology", "Nerve Tissue Proteins Genetics Metabolism", "Neurons Metabolism Pathology", "Inhibitors Genetics Metabolism", "N Methyl Dextro Aspartic Acid Receptor", "Disorders Of Mitochondrial Functions", "Priority Journal"
Page 1
Mitochondrial RNA modifications shape metabolic plasticity in metastasis.
Delaunay S, Pascual G, Feng B, Klann K, Behm M, Hotz-Wagenblatt A, Richter K, Zaoui K, Herpel E, Münch C, Dietmann S, Hess J, Benitah SA, Frye M. Delaunay S, et al. Nature. 2022 Jul;607(7919):593-603. doi: 10.1038/s41586-022-04898-5. Epub 2022 Jun 29. Nature. 2022. PMID: 35768510 Free PMC article.
Translation of mitochondrially encoded subunits of the oxidative phosphorylation complex depends on the formation of m(5)C at position 34 in mitochondrial tRNA(Met). m(5)C-deficient human oral cancer cells exhibit increased levels of glycolysis and changes in their …
Translation of mitochondrially encoded subunits of the oxidative phosphorylation complex depends on the formation of m(5)C at positio …
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang C, Sohn PD, Martin J, Zhou Y, Luo W, Trojanowski JQ, Lee VMY, Gong S, Manfredi G, Coppola G, Krogan NJ, Geschwind DH, Gan L. Tracy TE, et al. Cell. 2022 Feb 17;185(4):712-728.e14. doi: 10.1016/j.cell.2021.12.041. Epub 2022 Jan 20. Cell. 2022. PMID: 35063084 Free PMC article.
Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies. To dissect the underlying mechanisms, we combined an engineered ascorbic acid peroxidase (APEX) approach with quantitative affinity purification mass spectrometry (AP-MS) followe …
Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies. To dissect the underlying mechanisms, we comb …
Cancer metabolism: a therapeutic perspective.
Martinez-Outschoorn UE, Peiris-Pagés M, Pestell RG, Sotgia F, Lisanti MP. Martinez-Outschoorn UE, et al. Nat Rev Clin Oncol. 2017 Jan;14(1):11-31. doi: 10.1038/nrclinonc.2016.60. Epub 2016 May 4. Nat Rev Clin Oncol. 2017. PMID: 27141887 Review.
In general, tumour cells metabolize glucose, lactate, pyruvate, hydroxybutyrate, acetate, glutamine, and fatty acids at much higher rates than their nontumour equivalents; however, the metabolic ecology of tumours is complex because they contain multiple metaboli
In general, tumour cells metabolize glucose, lactate, pyruvate, hydroxybutyrate, acetate, glutamine, and fatty acids at much higher r …
Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.
Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T. Fecher C, et al. Nat Neurosci. 2019 Oct;22(10):1731-1742. doi: 10.1038/s41593-019-0479-z. Epub 2019 Sep 9. Nat Neurosci. 2019. PMID: 31501572
Here we engineered MitoTag mice, which express a Cre recombinase-dependent green fluorescent protein targeted to the outer mitochondrial membrane, and developed an isolation approach to profile tagged mitochondria from defined cell types. ...Based on p …
Here we engineered MitoTag mice, which express a Cre recombinase-dependent green fluorescent protein targeted to the outer mitochondrial
Pathological structural conversion of alpha-synuclein at the mitochondria induces neuronal toxicity.
Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, Fedotova EI, Berezhnov AV, De S, Peddie CJ, Athauda D, Virdi GS, Zhang W, Evans JR, Wernick AI, Zanjani ZS, Angelova PR, Esteras N, Vinokurov AY, Morris K, Jeacock K, Tosatto L, Little D, Gissen P, Clarke DJ, Kunath T, Collinson L, Klenerman D, Abramov AY, Horrocks MH, Gandhi S. Choi ML, et al. Nat Neurosci. 2022 Sep;25(9):1134-1148. doi: 10.1038/s41593-022-01140-3. Epub 2022 Aug 30. Nat Neurosci. 2022. PMID: 36042314 Free PMC article.
Mitochondrial aggregates impair complex I activity and increase mitochondrial reactive oxygen species (ROS) generation, which accelerates the oligomerization of A53T alpha-Syn and causes permeabilization of mitochondrial membranes and cell death
Mitochondrial aggregates impair complex I activity and increase mitochondrial reactive oxygen species (ROS) generation, which
Global mitochondrial protein import proteomics reveal distinct regulation by translation and translocation machinery.
Schäfer JA, Bozkurt S, Michaelis JB, Klann K, Münch C. Schäfer JA, et al. Mol Cell. 2022 Jan 20;82(2):435-446.e7. doi: 10.1016/j.molcel.2021.11.004. Epub 2021 Nov 29. Mol Cell. 2022. PMID: 34847359 Free PMC article.
Most mitochondrial proteins are translated in the cytosol and imported into mitochondria. Mutations in the mitochondrial protein import machinery cause human pathologies. ...We applied mePROD(mt) to determine protein uptake kinetics and examined …
Most mitochondrial proteins are translated in the cytosol and imported into mitochondria. Mutations in the mitochond
Alzheimer Disease.
Area-Gomez E, Schon EA. Area-Gomez E, et al. Adv Exp Med Biol. 2017;997:149-156. doi: 10.1007/978-981-10-4567-7_11. Adv Exp Med Biol. 2017. PMID: 28815528 Review.
However, there are other biochemical and morphological features of AD, including altered calcium, phospholipid, and cholesterol metabolism and altered mitochondrial dynamics and function that often appear early in the course of the disease, prior to plaque and tangl …
However, there are other biochemical and morphological features of AD, including altered calcium, phospholipid, and cholesterol metabolis
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
Narendra D, Tanaka A, Suen DF, Youle RJ. Narendra D, et al. J Cell Biol. 2008 Dec 1;183(5):795-803. doi: 10.1083/jcb.200809125. Epub 2008 Nov 24. J Cell Biol. 2008. PMID: 19029340 Free PMC article.
Its loss is associated with swollen mitochondria and muscle degeneration in Drosophila melanogaster, as well as mitochondrial dysfunction and increased susceptibility to mitochondrial toxins in other species. Here, we show that Parkin is selectively recruited …
Its loss is associated with swollen mitochondria and muscle degeneration in Drosophila melanogaster, as well as mitochondrial
PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress.
Verfaillie T, Rubio N, Garg AD, Bultynck G, Rizzuto R, Decuypere JP, Piette J, Linehan C, Gupta S, Samali A, Agostinis P. Verfaillie T, et al. Cell Death Differ. 2012 Nov;19(11):1880-91. doi: 10.1038/cdd.2012.74. Epub 2012 Jun 15. Cell Death Differ. 2012. PMID: 22705852 Free PMC article.
Endoplasmic reticulum stress is emerging as an important modulator of different pathologies and as a mechanism contributing to cancer cell death in response to therapeutic agents. ...Hence, this study reveals an unprecedented role of PERK as a MAMs component require …
Endoplasmic reticulum stress is emerging as an important modulator of different pathologies and as a mechanism contributing to cancer …
Mitochondrial potassium channels in cell death.
Checchetto V, Azzolini M, Peruzzo R, Capitanio P, Leanza L. Checchetto V, et al. Biochem Biophys Res Commun. 2018 May 27;500(1):51-58. doi: 10.1016/j.bbrc.2017.06.095. Epub 2017 Jun 19. Biochem Biophys Res Commun. 2018. PMID: 28642134 Review.
Mitochondria are intracellular organelles involved in several processes from bioenergetics to cell death. ...In this review, we will discuss the recent updates in the field, focusing our attention on the involvement of potassium channels during mitochondrial
Mitochondria are intracellular organelles involved in several processes from bioenergetics to cell death. ...In this review, w
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