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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 4
1993 8
1994 6
1995 5
1996 8
1997 7
1998 7
1999 16
2000 20
2001 27
2002 39
2003 66
2004 81
2005 57
2006 30
2007 26
2008 19
2009 17
2010 18
2011 17
2012 19
2013 11
2014 12
2015 14
2016 12
2017 6
2018 7
2019 5
2020 1
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521 results
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Annexin A5 regulates Leydig cell testosterone production via ERK1/2 pathway.
He Z, et al. Asian J Androl 2016. PMID 26289400 Free PMC article.
This study was to investigate the effect of annexin A5 on testosterone secretion from primary rat Leydig cells and the underlying mechanisms. ...Annexin A5 knockdown by siRNA significantly decreased the level of testosterone and protein expression of P450scc, 3β-HSD, and 17β-HSD. ...
This study was to investigate the effect of annexin A5 on testosterone secretion from primary rat Leydig cells and the underly …
Annexin A5 promotes macrophage activation and contributes to pulmonary fibrosis induced by silica particles.
Luo C, et al. Toxicol Ind Health 2016. PMID 25757482
OBJECTIVE: To investigate the contributions and underlying molecular mechanisms of annexin A5 toward silica-induced pulmonary fibrosis. ...These silica-induced changes were reversed by siRNA-mediated knockdown of annexin A5, but downregulation of FasL led to increased annexin A5 expression and reduced levels of TGF-β1, IL-1α, and FasL downstream target molecules. ...
OBJECTIVE: To investigate the contributions and underlying molecular mechanisms of annexin A5 toward silica-induced pulmonary …
Annexin-A5 organized in 2D-network at the plasmalemma eases human trophoblast fusion.
Degrelle SA, et al. Sci Rep 2017. PMID 28176826 Free PMC article.
Here, we demonstrate the role of annexin A5 (AnxA5) in syncytial formation by cellular delivery of recombinant AnxA5 and RNA interference. ...
Here, we demonstrate the role of annexin A5 (AnxA5) in syncytial formation by cellular delivery of recombinant AnxA5 and RNA i …
Annexin A5-conjugated polymeric micelles for dual SPECT and optical detection of apoptosis.
Zhang R, et al. J Nucl Med 2011. PMID 21571801 Free PMC article.
RESULTS: In cell-based studies, annexin A5-CCPM exhibited strongly specific binding to apoptotic tumor cells. This binding could be efficiently blocked by annexin A5. In mice, annexin A5-CCPM displayed a mean elimination half-life of 12.5 h. The mean initial concentration in blood was 22.4% of the injected dose/mL, and annexin A5-CCPM was mainly distributed in the central blood compartment. ...
RESULTS: In cell-based studies, annexin A5-CCPM exhibited strongly specific binding to apoptotic tumor cells. This binding cou …
Preclinical validation of 99mTc-annexin A5-128 in experimental autoimmune myocarditis and infective endocarditis: comparison with 99mTc-HYNIC-annexin A5.
Benali K, et al. Mol Imaging 2014. PMID 25431156
Hydrazinonicotinamide-annexin A5 (HYNIC-Anx), a 99m technetium (99mTc)-labeled agent targeting phosphatidylserine, proved to be sensitive for the detection of apoptosis and thrombosis but is no longer available for clinical use. A mutant of human annexin designed for direct 99mTc labeling (referred to as Anx A5-128) showed improved binding affinity to phosphatidylserine and is expected to be used in humans. ...
Hydrazinonicotinamide-annexin A5 (HYNIC-Anx), a 99m technetium (99mTc)-labeled agent targeting phosphatidylserine, proved to b …
Annexin A5 inhibits engulfment through internalization of PS-expressing cell membrane patches.
Kenis H, et al. Exp Cell Res 2006. PMID 16380116
Here, we investigated the role of PS in the phagocytosis of apoptotic cells using annexin A5. Using a novel flow cytometric-based phagocytosis assay, we observed that engulfment was inhibited with 20% if annexin A5 was added to PS-expressing cells that had completed apoptosis. The inhibition increased to more than 50% if annexin A5 was added during the apoptotic process. This inhibition is specific for annexin A5, since the mutant M23 and annexin A1 did not further increase the inhibition of phagocytosis when added during the apoptotic process. ...
Here, we investigated the role of PS in the phagocytosis of apoptotic cells using annexin A5. Using a novel flow cytometric-ba …
Functional Interactions between BK(Ca)α-Subunit and Annexin A5: Implications in Apoptosis.
Brazier SP, et al. Oxid Med Cell Longev 2016. PMID 27738490 Free PMC article.
Proteomic studies have suggested a biochemical interaction between α subunit of the large conductance, voltage- and Ca(2+)-activated potassium channel (BK(Ca)α), and annexin A5 (ANXA5), which we verify here by coimmunoprecipitation and double labelling immunocytochemistry. The observation that annexin is flipped to the outer membrane leaflet of the plasma membrane during apoptosis, together with the knowledge that the intracellular C-terminal of BK(Ca)α contains both Ca(2+)-binding and a putative annexin-binding motif, prompted us to investigate the functional consequences of this protein partnership to cell death. ...
Proteomic studies have suggested a biochemical interaction between α subunit of the large conductance, voltage- and Ca(2+)-activated potassi …
Annexin A5 multitasking: a potentially novel antiatherothrombotic agent?
Cederholm A and Frostegård J. Drug News Perspect 2007 - Review. PMID 17878960
Annexin A5 (ANXA5; previously annexin V), a member of the annexin superfamily, is a protein with potent and unique antithrombotic properties. ...
Annexin A5 (ANXA5; previously annexin V), a member of the annexin superfamily, is a protein with potent and uniq
The role of labeled Annexin A5 in imaging of programmed cell death. From animal to clinical imaging.
Kietselaer BL, et al. Q J Nucl Med 2003 - Review. PMID 14973424 Free article.
Annexin A5 binds to cells undergoing programmed cell death. When labeling this protein, Annexin A5 becomes a tool for the detection of programmed cell death in vitro and in vivo. ...Furthermore, we will discuss Annexin A5 imaging in human disease. We will focus on the clinical applications and their relevance, limitations and future perspectives of non-invasive imaging of programmed cell death using labeled Annexin A5....
Annexin A5 binds to cells undergoing programmed cell death. When labeling this protein, Annexin A5 becomes a too
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