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24,504,078 results

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Quoted phrases not found in phrase index: "Nucleotide Chemistry Metabolism", "Thrombin Chemistry Metabolism"
Page 1
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.
Li S, Jiang Q, Liu S, Zhang Y, Tian Y, Song C, Wang J, Zou Y, Anderson GJ, Han JY, Chang Y, Liu Y, Zhang C, Chen L, Zhou G, Nie G, Yan H, Ding B, Zhao Y. Li S, et al. Nat Biotechnol. 2018 Mar;36(3):258-264. doi: 10.1038/nbt.4071. Epub 2018 Feb 12. Nat Biotechnol. 2018. PMID: 29431737
Our nanorobot is functionalized on the outside with a DNA aptamer that binds nucleolin, a protein specifically expressed on tumor-associated endothelial cells, and the blood coagulation protease thrombin within its inner cavity. The nucleolin-targeting aptamer serves both …
Our nanorobot is functionalized on the outside with a DNA aptamer that binds nucleolin, a protein specifically expressed on tumor-associated …
Modular protein-oligonucleotide signal exchange.
Agrawal DK, Schulman R. Agrawal DK, et al. Nucleic Acids Res. 2020 Jul 9;48(12):6431-6444. doi: 10.1093/nar/gkaa405. Nucleic Acids Res. 2020. PMID: 32442276 Free PMC article.
Using this strategy, we implemented four different exchange processes to report the concentrations of clinically relevant human alpha-thrombin and vascular endothelial growth factor using changes in concentrations of DNA oligonucleotide outputs. ...
Using this strategy, we implemented four different exchange processes to report the concentrations of clinically relevant human alpha-thr …
Aptamers and biosensors.
Gronewold TM. Gronewold TM. Methods Mol Biol. 2009;535:209-22. doi: 10.1007/978-1-59745-557-2_13. Methods Mol Biol. 2009. PMID: 19377993
To characterize the immobilization onto various biolayers, the interaction of DNA anti-thrombin aptamer with the protein thrombin was used as a model system. The aptamer was immobilized to a two-dimensional alkanethiol SAM via carboxylamide bonds and t …
To characterize the immobilization onto various biolayers, the interaction of DNA anti-thrombin aptamer with the protei …
Thrombin binding aptamer G-quadruplex stabilized by pyrene-modified nucleotides.
Kovačič M, Podbevšek P, Tateishi-Karimata H, Takahashi S, Sugimoto N, Plavec J. Kovačič M, et al. Nucleic Acids Res. 2020 Apr 17;48(7):3975-3986. doi: 10.1093/nar/gkaa118. Nucleic Acids Res. 2020. PMID: 32095808 Free PMC article.
We have investigated the effect of pyrene-modified uridine nucleotides incorporated at several positions of the thrombin binding aptamer (TBA) as a model system. ...Site specific structural changes induced by stacking of the pyrene moiety on nearby nucleobases corel …
We have investigated the effect of pyrene-modified uridine nucleotides incorporated at several positions of the thrombin bindi …
Exosite Binding in Thrombin: A Global Structural/Dynamic Overview of Complexes with Aptamers and Other Ligands.
Troisi R, Balasco N, Autiero I, Vitagliano L, Sica F. Troisi R, et al. Int J Mol Sci. 2021 Oct 6;22(19):10803. doi: 10.3390/ijms221910803. Int J Mol Sci. 2021. PMID: 34639143 Free PMC article. Review.
Thrombin can perform its many functional activities because of its ability to recognize a wide variety of substrates, inhibitors, and cofactors. ...Collectively, the data and the work here reviewed may provide insights into the design of novel thrombin inhibitors... …
Thrombin can perform its many functional activities because of its ability to recognize a wide variety of substrates, inhibitors, and …
Aptamer binding assays for proteins: the thrombin example--a review.
Deng B, Lin Y, Wang C, Li F, Wang Z, Zhang H, Li XF, Le XC. Deng B, et al. Anal Chim Acta. 2014 Jul 21;837:1-15. doi: 10.1016/j.aca.2014.04.055. Epub 2014 May 2. Anal Chim Acta. 2014. PMID: 25000852 Free article. Review.
This paper critically reviews more than one hundred assays that are based on aptamer binding to thrombin. This review focuses on homogeneous binding assays, electrochemical aptasensors, and affinity separation techniques. The emphasis of this review is placed on understand …
This paper critically reviews more than one hundred assays that are based on aptamer binding to thrombin. This review focuses on homo …
Thrombin-binding properties of thrombin aptamer derivatives.
Sumikura K, Yano K, Ikebukuro K, Karube I. Sumikura K, et al. Nucleic Acids Symp Ser. 1997;(37):257-8. Nucleic Acids Symp Ser. 1997. PMID: 9586097
We synthesized a single-stranded DNA with triple G-quartet structure and found that its thrombin-binding activity at 37 degrees C is as much as that of thrombin aptamer with double G-quartet structure which is a product of in vitro selection and amplification. ...
We synthesized a single-stranded DNA with triple G-quartet structure and found that its thrombin-binding activity at 37 degrees C is …
Dual-reporter SERS-based biomolecular assay with reduced false-positive signals.
Chuong TT, Pallaoro A, Chaves CA, Li Z, Lee J, Eisenstein M, Stucky GD, Moskovits M, Soh HT. Chuong TT, et al. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9056-9061. doi: 10.1073/pnas.1700317114. Epub 2017 Aug 7. Proc Natl Acad Sci U S A. 2017. PMID: 28784766 Free PMC article.
We link one Raman reporter-tagged affinity reagent to gold nanoparticles and another to a gold film, such that protein-binding events create a "hot spot" with strong SERS spectra from both Raman reporter molecules. ...We show that the number of hot spots per unit ar …
We link one Raman reporter-tagged affinity reagent to gold nanoparticles and another to a gold film, such that protein-binding …
Stability Is Not Everything: The Case of the Cyclisation of a Thrombin-Binding Aptamer.
Riccardi C, Meyer A, Vasseur JJ, Russo Krauss I, Paduano L, Oliva R, Petraccone L, Morvan F, Montesarchio D. Riccardi C, et al. Chembiochem. 2019 Jul 15;20(14):1789-1794. doi: 10.1002/cbic.201900045. Epub 2019 May 14. Chembiochem. 2019. PMID: 30860635
With the aim of developing a new approach to obtain improved aptamers, a cyclic thrombin-binding aptamer (TBA) analogue (cycTBA) has been prepared by exploiting a copper(I)-assisted azide-alkyne cycloaddition. The markedly increased serum resistance and exceptional thermal …
With the aim of developing a new approach to obtain improved aptamers, a cyclic thrombin-binding aptamer (TBA) analogue (cycTBA) has …
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