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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 5
1946 27
1947 13
1948 15
1949 2
1951 100
1952 236
1953 276
1954 317
1955 409
1956 434
1957 563
1958 570
1959 512
1960 469
1961 499
1962 308
1963 3
1964 36
1965 424
1966 542
1967 584
1968 642
1969 694
1970 654
1971 700
1972 658
1973 590
1974 679
1975 621
1976 740
1977 741
1978 794
1979 864
1980 786
1981 929
1982 1082
1983 1018
1984 1001
1985 932
1986 1035
1987 1051
1988 945
1989 973
1990 993
1991 931
1992 799
1993 834
1994 846
1995 1194
1996 1623
1997 1764
1998 1942
1999 1951
2000 2071
2001 2305
2002 2352
2003 2403
2004 2650
2005 3207
2006 3388
2007 3762
2008 4001
2009 4276
2010 4523
2011 5272
2012 5670
2013 6157
2014 6422
2015 6764
2016 6742
2017 7059
2018 7510
2019 4207
2020 85
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118,079 results
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Page 1
Rifamycins, Alone and in Combination
Rothstein DM. Cold Spring Harb Perspect Med 2016 - Review. PMID 27270559 Free PMC article.
Rifamycins inhibit RNA polymerase of most bacterial genera. Rifampicin remains part of combination therapy for treating tuberculosis (TB), and for treating Gram-positive prosthetic joint and valve infections, in which biofilms are prominent. ...Rifaximin is confined to the GI tract because it is not systemically absorbed on oral dosing, achieving high local concentrations, and showing anti-inflammatory properties in addition to its antibacterial activity. ...
Rifamycins inhibit RNA polymerase of most bacterial genera. Rifampicin remains part of combination therapy for treating tuberculosis …
Bacterial Adaptation to Antibiotics through Regulatory RNAs.
Felden B and Cattoir V. Antimicrob Agents Chemother 2018 - Review. PMID 29530859 Free PMC article.
The recent implication of regulatory RNAs (small RNAs [sRNAs]) in antibiotic response and resistance in several bacterial pathogens suggests that they should be considered innovative drug targets. ...Of interest is the lack of knowledge about sRNAs implicated in Gram-positive compared to Gram-negative bacterial resistance....
The recent implication of regulatory RNAs (small RNAs [sRNAs]) in antibiotic response and resistance in several bacterial pathogens s …
Antibiotic susceptibility, cytotoxicity, and protease activity of viridans group streptococci causing endophthalmitis
Marquart ME, et al. PLoS One 2018. PMID 30576393 Free PMC article.
The viridans group streptococci comprise multiple species and have gained more recognition in recent years as common etiologic agents of bacterial endophthalmitis. ...Susceptibilities to 3 antibiotics commonly used for bacterial endophthalmitis were determined. The extracellular milieu of each strain was tested for cytotoxicity of retinal pigmented epithelial cells, hemolysis of sheep erythrocytes, and protease activity using gelatin zymography. ...
The viridans group streptococci comprise multiple species and have gained more recognition in recent years as common etiologic agents
The aminoglycosides
Edson RS and Terrell CL. Mayo Clin Proc 1991 - Review. PMID 1943249
Despite the introduction of newer, less toxic antimicrobial agents, the aminoglycosides continue to serve a useful role in the treatment of serious enterococcal and gram-negative bacillary infections. ...
Despite the introduction of newer, less toxic antimicrobial agents, the aminoglycosides continue to serve a useful role in the treatm …
Antibiotic synergy and antagonism
Acar JF. Med Clin North Am 2000 - Review. PMID 11155849
Any practitioner in infectious diseases has some individual cases, published or unpublished, which add some evidence to the role of synergistic combinations in difficult therapy problems--either on the side of the patient when immunosuppressed or on the side of the bacterial strain, when multiply resistant. MRSA, VISA, E. faecium resistant to penicillin G and highly resistant to aminoglysocides and to vancomycin, P. aeruginosa resistant to ceftazidime and imipenem, and Acinetobacter baumani resistant to imipenem are some of the bacterial strains dangerous for the patient and the hospital, which trigger the imagination of the microbiologist and physician to find a satisfactory treatment. ...
Any practitioner in infectious diseases has some individual cases, published or unpublished, which add some evidence to the role of synergis …
Pharmacokinetics and pharmacodynamics of antibacterial agents.
Levison ME and Levison JH. Infect Dis Clin North Am 2009 - Review. PMID 19909885 Free PMC article.
Important pharmacodynamic concepts include the requirements for bactericidal therapy for endocarditis and meningitis, for synergistic combinations to treat enterococcal endocarditis or to shorten the course of antimicrobial therapy, for obtaining maximal plasma concentration/minimal inhibitory concentration (MIC) ratios that are greater than 10 or 24 hour-area under the plasma concentration curve (AUC)/MIC ratios that are greater than 100-125 for concentration-dependent agents against gram-negative bacilli and 25-35 against Streptococcus pneumoniae, and for obtaining percent of time that drug levels are greater than the MIC that is at least 40% to 50% of the dosing interval for time-dependent agents....
Important pharmacodynamic concepts include the requirements for bactericidal therapy for endocarditis and meningitis, for synergistic combin …
[Macrolide]
Azuma A and Kudoh S. Nihon Rinsho 2003 - Review. PMID 12722320 Japanese.
Antibiotics: Precious Goods in Changing Times
Sass P. Methods Mol Biol 2017 - Review. PMID 27873243
For antimicrobial activity, nature has invented a great variety of mechanisms of antibiotic action that involve the perturbation of essential bacterial structures or biosynthesis pathways of macromolecules such as the bacterial cell wall, DNA, RNA, or proteins, thereby threatening the specific microbial lifestyle and eventually even survival. ...Microorganisms have evolved specific adaptive responses that allow appropriately reacting to the presence of antimicrobial agents, ensuring survival during antimicrobial stress. ...
For antimicrobial activity, nature has invented a great variety of mechanisms of antibiotic action that involve the perturbation of essentia …
Antimicrobial Pharmacokinetics and Pharmacodynamics in Older Adults
Benson JM. Infect Dis Clin North Am 2017 - Review. PMID 29079151
Pharmacodynamic models that apply to antibacterial agents are reviewed, as are likely effects of aging on these models. The understanding of how older adults respond in terms of efficacy and toxicity is increasing but limited. ...
Pharmacodynamic models that apply to antibacterial agents are reviewed, as are likely effects of aging on these models. The understan …
Detection of Antibiotics and Evaluation of Antibacterial Activity with Screen-Printed Electrodes
Munteanu FD, et al. Sensors (Basel) 2018 - Review. PMID 29562637 Free PMC article.
With regards to detection of bacteria, the emphasis is placed on applications targeting viable bacterial cells. While the electrochemical sensors and biosensors face many challenges before replacing standard analysis methods, the potential of screen-printed electrodes is increasingly exploited and more applications are anticipated to advance towards commercial analytical tools....
With regards to detection of bacteria, the emphasis is placed on applications targeting viable bacterial cells. While the electrochem …
118,079 results
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