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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 1
1948 2
1949 1
1950 4
1951 147
1952 475
1953 608
1954 669
1955 665
1956 624
1957 729
1958 716
1959 275
1960 3
1961 4
1962 4
1963 5
1964 34
1965 595
1966 749
1967 725
1968 648
1969 674
1970 618
1971 630
1972 533
1973 504
1974 546
1975 487
1976 531
1977 534
1978 572
1979 644
1980 555
1981 713
1982 787
1983 742
1984 846
1985 823
1986 863
1987 884
1988 843
1989 800
1990 922
1991 865
1992 755
1993 761
1994 796
1995 1058
1996 1457
1997 1586
1998 1760
1999 1812
2000 1843
2001 1965
2002 2006
2003 2066
2004 2238
2005 2567
2006 2789
2007 2844
2008 3215
2009 3150
2010 3306
2011 3723
2012 4165
2013 4622
2014 4920
2015 5267
2016 4940
2017 5034
2018 4870
2019 2494
2020 38
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95,410 results
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Page 1
Outpatient antibiotic stewardship: Interventions and opportunities
Dobson EL, et al. J Am Pharm Assoc (2003) 2017 - Review. PMID 28526402
Improving the use of antibiotics across the continuum of care is a national priority. Data outlining the misuse of antibiotics in the outpatient setting justify the expansion of antibiotic stewardship programs (ASPs) into this health care setting; however, best practices for outpatient antibiotic stewardship (AS) are not yet defined. ...This article summarizes examples of point-of-care testing, policies and interventions, and education strategies to improve antibiotic use that can be used in the outpatient setting....
Improving the use of antibiotics across the continuum of care is a national priority. Data outlining the misuse of antibiotics in the …
Global increase and geographic convergence in antibiotic consumption between 2000 and 2015
Klein EY, et al. Proc Natl Acad Sci U S A 2018. PMID 29581252 Free PMC article.
Of particular concern was the rapid increase in the use of last-resort compounds, both in HICs and LMICs, such as glycylcyclines, oxazolidinones, carbapenems, and polymyxins. ...Although antibiotic consumption rates in most LMICs remain lower than in HICs despite higher bacterial disease burden, consumption in LMICs is rapidly converging to rates similar to HICs. ...
Of particular concern was the rapid increase in the use of last-resort compounds, both in HICs and LMICs, such as glycylcyclines, oxa …
Finding alternatives to antibiotics
Allen HK, et al. Ann N Y Acad Sci 2014 - Review. PMID 24953233 Free article.
Interestingly, several of these methods augment antibiotic efficacy by improving bacterial killing and decreasing antibiotic resistance selection. Because bacteria can ultimately evolve resistance to almost any therapeutic agent, it is important to continue to use both antibiotics and their alternatives judiciously....
Interestingly, several of these methods augment antibiotic efficacy by improving bacterial killing and decreasing antibiotic resistan …
General principles of antimicrobial therapy
Leekha S, et al. Mayo Clin Proc 2011. PMID 21282489 Free PMC article.
Antimicrobial agents are some of the most widely, and often injudiciously, used therapeutic drugs worldwide. Important considerations when prescribing antimicrobial therapy include obtaining an accurate diagnosis of infection; understanding the difference between empiric and definitive therapy; identifying opportunities to switch to narrow-spectrum, cost-effective oral agents for the shortest duration necessary; understanding drug characteristics that are peculiar to antimicrobial agents (such as pharmacodynamics and efficacy at the site of infection); accounting for host characteristics that influence antimicrobial activity; and in turn, recognizing the adverse effects of antimicrobial agents on the host. ...By following these general principles, all practicing physicians should be able to use antimicrobial agents in a responsible manner that benefits both the individual patient and the community....
Antimicrobial agents are some of the most widely, and often injudiciously, used therapeutic drugs worldwide. Important conside …
[Adequate anti-infective treatment : Importance of individual dosing and application].
Brinkmann A, et al. Anaesthesist 2018 - Review. PMID 29766208 German.
Alterations to the substance-specific kinetics of anti-infective substances have an effect on the distribution and excretion processes in the body. ...Current international guidelines recommend individualized dosing strategies and adaptation of doses according to measured serum levels and pharmacokinetic/pharmacodynamic (PK/PD) parameters as concepts to optimize anti-infective therapy in the critically ill. ...
Alterations to the substance-specific kinetics of anti-infective substances have an effect on the distribution and excretion processe …
A New Antibiotic
Reishtein JL. Am J Nurs 2016. PMID 26817564
Development of operationalized intravenous to oral antibiotic switch criteria
Akhloufi H, et al. J Antimicrob Chemother 2017. PMID 27999021
Future use of these criteria in audits and as rules in clinical decision support systems will facilitate the performance and evaluation of iv-oral switch programmes....
Future use of these criteria in audits and as rules in clinical decision support systems will facilitate the performance and evaluati …
95,410 results
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