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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1972 1
1974 2
1975 4
1976 26
1977 21
1978 20
1979 35
1980 15
1981 22
1982 28
1983 32
1984 30
1985 31
1986 118
1987 237
1988 226
1989 256
1990 294
1991 283
1992 318
1993 345
1994 310
1995 437
1996 498
1997 522
1998 520
1999 600
2000 639
2001 810
2002 915
2003 800
2004 857
2005 1065
2006 959
2007 906
2008 737
2009 808
2010 802
2011 816
2012 833
2013 836
2014 783
2015 755
2016 652
2017 602
2018 514
2019 257
2020 5
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19,401 results
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Page 1
Non-steroidal anti-inflammatory drug-induced cardiovascular adverse events: a meta-analysis.
Gunter BR, et al. J Clin Pharm Ther 2017 - Review. PMID 28019014
WHAT IS KNOWN AND OBJECTIVE: Although non-steroidal anti-inflammatory drugs (NSAIDs) have been studied in randomized, controlled trials and meta-analyses in an effort to determine their cardiovascular (CV) risks, no consensus has been reached. ...Comparisons were made between all included drugs, against placebo, and against non-selective NSAIDs (nsNSAIDs). Drugs were also compared against COX-2 selective inhibitors (COXIBs) with and without inclusion of rofecoxib. ...
WHAT IS KNOWN AND OBJECTIVE: Although non-steroidal anti-inflammatory drugs (NSAIDs) have been studied in random …
Individual non-steroidal anti-inflammatory drugs and risk of acute kidney injury: A systematic review and meta-analysis of observational studies.
Ungprasert P, et al. Eur J Intern Med 2015 - Review. PMID 25862494
BACKGROUND: The association between acute kidney injury (AKI) and use of non-steroidal anti-inflammatory drugs (NSAIDs) is well established. ...METHODS: We conducted a systematic review and meta-analysis of cohort studies that reported relative risk, hazard ratio or standardized incidence ratio with 95% confidence comparing AKI risk in NSAID users versus non-users. ...
BACKGROUND: The association between acute kidney injury (AKI) and use of non-steroidal anti-inflammatory drugs ( …
Systematic review of nonsteroidal anti-inflammatory drug-induced adverse effects in dogs.
Monteiro-Steagall BP, et al. J Vet Intern Med 2013 - Review. PMID 23782347 Free article.
The aim of this systematic review was to identify, assess, and critically evaluate the quality of evidence of nonsteroidal anti-inflammatory drug (NSAID)-induced adverse effects in dogs. ...Adverse effects were detected in 35 studies (55%) and commonly included vomiting, diarrhea, and anorexia. Three studies (5%) reported a power analysis related to adverse effects of ≥80%. ...
The aim of this systematic review was to identify, assess, and critically evaluate the quality of evidence of nonsteroidal anti-in
[Cardiovascular safety of non-steroidal anti-inflammatory drugs].
Møllersen MV, et al. Tidsskr Nor Laegeforen 2015 - Review. PMID 25806762 Norwegian. Free article.
We have evaluated data on adverse cardiovascular effects caused by COX-2 inhibitors and other non-steroidal anti-inflammatory drugs (NSAIDs) since 2004. ...The effects of length of treatment and predisposition for cardiovascular disease are less clear. INTERPRETATION: Adverse cardiovascular effects is as a group effect that applies to all the NSAIDs studied, except for naproxen and low-dose ibuprofen. ...
We have evaluated data on adverse cardiovascular effects caused by COX-2 inhibitors and other non-steroidal a
Lead optimization on conventional non-steroidal anti-inflammatory drugs: an approach to reduce gastrointestinal toxicity.
Narsinghani T and Sharma R. Chem Biol Drug Des 2014 - Review. PMID 24460671
Non-steroidal anti-inflammatory drugs exert their anti-inflammatory and antipyretic effects by blocking the production of prostanoids from arachidonic acid through inhibition ofcyclooxygenase enzyme. ...To provide an effective treatment for inflammatory disorders, the design of novel non-steroidal anti-inflammatory drugs is aimed at obtaining new drugs, devoid of the side-effects commonly associated with conventional non-steroidal anti-inflammatory drugs. ...
Non-steroidal anti-inflammatory drugs exert their anti-inflammatory and antipyretic effects
Nonsteroidal anti-inflammatory drugs for dysmenorrhoea.
Marjoribanks J, et al. Cochrane Database Syst Rev 2015 - Review. PMID 26224322 Free PMC article.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are drugs that act by blocking prostaglandin production. They inhibit the action of cyclooxygenase (COX), an enzyme responsible for the formation of prostaglandins. ...This suggests that if 18% of women taking placebo achieve moderate or excellent pain relief, between 45% and 53% taking NSAIDs will do so.However, NSAIDs were associated with more adverse effects (overall adverse effects: OR 1.29, 95% CI 1.11 to 1.51, 25 RCTs, I(2) = 0%, low quality evidence; gastrointestinal adverse effects: OR 1.58, 95% CI 1.12 to 2.23, 14 RCTs, I(2) = 30%; neurological adverse effects: OR 2.74, 95% CI 1.66 to 4.53, seven RCTs, I(2) = 0%, low quality evidence). ...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are drugs that act by blocking prostaglandin production. They inhibit the action …
Cyclo-Oxygenase (COX) Inhibitors and Cardiovascular Risk: Are Non-Steroidal Anti-Inflammatory Drugs Really Anti-Inflammatory?
Khan S, et al. Int J Mol Sci 2019 - Review. PMID 31480335 Free PMC article.
Cyclo-oxygenase (COX) inhibitors are among the most commonly used drugs in the western world for their anti-inflammatory and analgesic effects. ...
Cyclo-oxygenase (COX) inhibitors are among the most commonly used drugs in the western world for their anti-inflammatory and a …
NSAIDs and cardiovascular risk
Marsico F, et al. J Cardiovasc Med (Hagerstown) 2017 - Review. PMID 27652819
NSAIDs are the most largely used class of drugs in the world, due to their large use in many diseases, in particular for the systemic inflammatory diseases. ...Mechanisms of the cardiovascular side effects are controversial yet, so the aim of this document is to review side-effects profile of NSAIDs and, specifically, to investigate cardiovascular consequences of NSAIDs use in clinical practice....
NSAIDs are the most largely used class of drugs in the world, due to their large use in many diseases, in particular for the systemic inf
Gastrointestinal risk of non-steroidal anti-inflammatory drugs and gastroprotective agents used in the treatment of osteoarthritis in elderly patients: A nationwide retrospective cohort study
.
Han MH, et al. Int J Clin Pharmacol Ther 2019. PMID 31397273
OBJECTIVE: Osteoarthritis is highly prevalent in older adults and often treated with nonsteroidal anti-inflammatory drugs (NSAIDs). COX-2-selective NSAIDs have been shown to offer better gastrointestinal (GI) safety benefits than non-selective NSAIDs (ns-NSAIDs). ...
OBJECTIVE: Osteoarthritis is highly prevalent in older adults and often treated with nonsteroidal anti-inflammatory drugs (NSA …
Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs: an update on pharmacogenetics studies.
Plaza-Serón MDC, et al. Pharmacogenomics 2018 - Review. PMID 30081739
Nonsteroidal anti-inflammatory drugs are the medications most frequently involved in hypersensitivity reactions to drugs. These can be induced by specific immunological and nonimmunological mechanisms, being the latter the most frequent. ...The proposals of this review is summarize the contribution of variations in genes involved in the arachidonic acid, inflammatory and immune pathways as well as the recent genome-wide association studies findings related to cross-intolerant nonsteroidal anti-inflammatory drugs hypersensitivity reactions. ...
Nonsteroidal anti-inflammatory drugs are the medications most frequently involved in hypersensitivity reactions to drugs. Thes …
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