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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 2
1967 5
1968 17
1969 15
1970 26
1971 27
1972 32
1973 34
1974 51
1975 40
1976 33
1977 43
1978 49
1979 46
1980 36
1981 51
1982 36
1983 49
1984 48
1985 43
1986 46
1987 35
1988 29
1989 46
1990 54
1991 60
1992 95
1993 78
1994 97
1995 98
1996 124
1997 137
1998 186
1999 198
2000 231
2001 314
2002 302
2003 322
2004 361
2005 469
2006 499
2007 603
2008 627
2009 665
2010 801
2011 931
2012 949
2013 1045
2014 1042
2015 1075
2016 1111
2017 1194
2018 1233
2019 740
2020 9
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14,728 results
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Page 1
Coumarin Derivatives as Anti-inflammatory and Anticancer Agents.
Thomas V, et al. Anticancer Agents Med Chem 2017. PMID 27592545
Tumor microenvironment, products of inflammatory cells influence almost every aspect of tumorigenesis and tumor progression. ...RESULTS: Compound 4b showed significant anti-inflammatory and anticancer activity. CONCLUSION: According to the results, it was concluded that designing compounds targeting cancer-related inflammation could be helpful in developing promising drug candidates for the treatment of cancer....
Tumor microenvironment, products of inflammatory cells influence almost every aspect of tumorigenesis and tumor progression. ...RESUL …
Synthesis and Biological Evaluation of New Phthalazinone Derivatives as Anti-Inflammatory and Anti-Proliferative Agents.
Hameed AD, et al. Arch Pharm (Weinheim) 2016. PMID 26725221
So this study aims to synthesize a library of phthalazine derivatives and to investigate their anti-inflammatory and anti-proliferative activities. Sixteen new phthalazinone derivatives (2a-p) were synthesized and tested for their in vitro antiproliferative and in vivo anti-inflammatory activities. ...
So this study aims to synthesize a library of phthalazine derivatives and to investigate their anti-inflammatory and anti
Nature is the best source of anti-inflammatory drugs: indexing natural products for their anti-inflammatory bioactivity.
Aswad M, et al. Inflamm Res 2018. PMID 28956064
OBJECTIVES: The aim was to index natural products for less expensive preventive or curative anti-inflammatory therapeutic drugs. ...The other seven phytochemicals await evaluation for their anti-inflammatory activity in wet lab. CONCLUSION: The proposed anti-inflammatory model can be utilized for the virtual screening of large chemical databases and for indexing natural products for potential anti-inflammatory activity....
OBJECTIVES: The aim was to index natural products for less expensive preventive or curative anti-inflammatory therapeutic drug …
Synthesis of Novel Substituted Thiourea and Benzimidazole Derivatives Containing a Pyrazolone Ring as Anti-Inflammatory Agents.
Moneer AA, et al. Chem Biol Drug Des 2016. PMID 26684979
Compounds 2c, 2f, 2g, 3b, and 3g that showed the highest COX-2 inhibitory activity were selected for further in vivo testing as anti-inflammatory agents using diclofenac as a reference drug. ...SAR study of the two series as cyclooxygenase inhibitors and anti-inflammatory agents was also provided....
Compounds 2c, 2f, 2g, 3b, and 3g that showed the highest COX-2 inhibitory activity were selected for further in vivo testing as anti- …
Anti-inflammatory agents as cancer therapeutics.
Kashfi K. Adv Pharmacol 2009 - Review. PMID 20230759
The seminal epidemiological observation that nonsteroidal anti-inflammatory drugs (NSAIDs) prevent colon and other cancers has provided the impetus to develop novel chemoprevention approaches against cancer. ...In addition to these novel agents, there are also a host of naturally occurring compounds/micronutrients that have chemopreventive properties. ...
The seminal epidemiological observation that nonsteroidal anti-inflammatory drugs (NSAIDs) prevent colon and other cancers has …
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.
Singh P, et al. Eur J Med Chem 2015. PMID 25956953
The indoles bearing a tosyl group at N-1 and a dipeptide substituent at C-3 were screened for anti-inflammatory and anti-hyperalgesic activities. ...The most potent compounds 7b, 7d and 7h showed no toxicity to the animals and were identified as the promising leads for anti-inflammatory drugs....
The indoles bearing a tosyl group at N-1 and a dipeptide substituent at C-3 were screened for anti-inflammatory and anti
Novel anti-inflammatory agents targeting CXCR4: Design, synthesis, biological evaluation and preliminary pharmacokinetic study.
Bai R, et al. Eur J Med Chem 2017. PMID 28521261 Free PMC article.
CXCR4 plays a crucial role in the inflammatory disease process, providing an attractive means for drug targeting. A series of novel amide-sulfamide derivatives were designed, synthesized and comprehensively evaluated. ...
CXCR4 plays a crucial role in the inflammatory disease process, providing an attractive means for drug targeting. A series of novel a …
Recent Findings in Molecular Basis of Inflammation and Anti-inflammatory Plants.
Kazemi S, et al. Curr Pharm Des 2018 - Review. PMID 29611479
Unfortunately, commercial available anti-inflammatory drugs are not free from side effects. Hence, there is an urgent need for introducing potent, nontoxic or less toxic antiinflammatory drugs. Recently, substantial progress has been made in the understanding of inflammatory mechanisms which may open new avenues for the preparation of novel anti-inflammatory drugs. ...
Unfortunately, commercial available anti-inflammatory drugs are not free from side effects. Hence, there is an urgent need for …
Synthesis of phenylpiperazine derivatives of 1,4-benzodioxan as selective COX-2 inhibitors and anti-inflammatory agents.
Sun J, et al. Bioorg Med Chem 2016. PMID 27658794
The biological activity of compound 3k as anti-inflammatory agent was further investigated both in vitro and in vivo. Notably, compound 3k exhibited the best anti-inflammatory activity among the eleven designed compounds with no toxicity, as determined by the ulcerogenic activity. ...Compound 3k maybe a new anti-inflammatory lead-candidate as powerful and novel non-ulcerogenic....
The biological activity of compound 3k as anti-inflammatory agent was further investigated both in vitro and in vivo. Notably, …
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