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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 15
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 409
1829 568
1830 510
1831 579
1832 284
1833 221
1834 209
1835 222
1836 220
1837 281
1838 265
1839 289
1840 395
1841 829
1842 971
1843 813
1844 609
1845 681
1846 746
1847 774
1848 799
1849 744
1850 756
1851 773
1852 765
1853 901
1854 827
1855 1091
1856 1283
1857 1275
1858 1339
1859 1319
1860 1210
1861 945
1862 904
1863 823
1864 938
1865 936
1866 1238
1867 1433
1868 1510
1869 1578
1870 1531
1871 1915
1872 1976
1873 2037
1874 2164
1875 2147
1876 1935
1877 2006
1878 2241
1879 2176
1880 2449
1881 2736
1882 2270
1883 2731
1884 2785
1885 3063
1886 3088
1887 3726
1888 3713
1889 4024
1890 3901
1891 3445
1892 3943
1893 4215
1894 3657
1895 4018
1896 4302
1897 4548
1898 4510
1899 4031
1900 3661
1901 3764
1902 3829
1903 3777
1904 3937
1905 3962
1906 3872
1907 4323
1908 4513
1909 4766
1910 4885
1911 5099
1912 5016
1913 5250
1914 5243
1915 4702
1916 4569
1917 4274
1918 4210
1919 4478
1920 5037
1921 4703
1922 4192
1923 4519
1924 4945
1925 5058
1926 5397
1927 5945
1928 5537
1929 5798
1930 5694
1931 5572
1932 5629
1933 5695
1934 5577
1935 5736
1936 5448
1937 5378
1938 5829
1939 5614
1940 5024
1941 4865
1942 4800
1943 4543
1944 4764
1945 20490
1946 53907
1947 65016
1948 70704
1949 62796
1950 85769
1951 103731
1952 108067
1953 108904
1954 105914
1955 108544
1956 107007
1957 111522
1958 109458
1959 109962
1960 112139
1961 120103
1962 125636
1963 141521
1964 162087
1965 176645
1966 179743
1967 191507
1968 207850
1969 215035
1970 218966
1971 222884
1972 227487
1973 230631
1974 234519
1975 248224
1976 250424
1977 250200
1978 258745
1979 266037
1980 267704
1981 272017
1982 283637
1983 295335
1984 303270
1985 319597
1986 332022
1987 348153
1988 364644
1989 378778
1990 383834
1991 381591
1992 383343
1993 391167
1994 402593
1995 411965
1996 422200
1997 419952
1998 437891
1999 455149
2000 492107
2001 504522
2002 522368
2003 549994
2004 593234
2005 651997
2006 698934
2007 735080
2008 782057
2009 821213
2010 883395
2011 957049
2012 1023156
2013 1074009
2014 1125796
2015 1166076
2016 1197819
2017 1218220
2018 1261549
2019 1317478
2020 1500212
2021 1635397
2022 1626130
2023 692549
2024 4

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33,534,710 results

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Page 1
Using protein kinase and protein phosphatase inhibitors to dissect protein phosphorylation pathways.
Karaszkiewicz JW, Henrich CJ. Karaszkiewicz JW, et al. Curr Protoc Immunol. 2001 May;Chapter 11:11.7.1-11.7.20. doi: 10.1002/0471142735.im1107s22. Curr Protoc Immunol. 2001. PMID: 18432707
The protocols in this unit describe how to assay a variety of protein kinase activities in complex mixtures, such as whole cell lysates, in order to screen compounds as potential inhibitors of these activities. ...Support protocols …
The protocols in this unit describe how to assay a variety of protein kinase activities in complex mixtures, suc …
Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway.
Mathew A, Mathur SK, Morimoto RI. Mathew A, et al. Mol Cell Biol. 1998 Sep;18(9):5091-8. doi: 10.1128/MCB.18.9.5091. Mol Cell Biol. 1998. PMID: 9710593 Free PMC article.
HSF2 DNA-binding activity is induced upon exposure of mammalian cells to the proteasome inhibitors hemin, MG132, and lactacystin, and in the mouse ts85 cell line, which carries a temperature sensitivity mutation in the ubiquitin-activatin …
HSF2 DNA-binding activity is induced upon exposure of mammalian cells to the proteasome inhibitors hemin, …
The effect of MG132, a proteasome inhibitor on HeLa cells in relation to cell growth, reactive oxygen species and GSH.
Han YH, Moon HJ, You BR, Park WH. Han YH, et al. Oncol Rep. 2009 Jul;22(1):215-21. Oncol Rep. 2009. PMID: 19513526
MG132 (carbobenzoxy-Leu-Leu-leucinal) is a peptide aldehyde, which effectively blocks the proteolytic activity of the 26S proteasome complex. We evaluated the effects of MG132 on the growth of human cervix cancer HeLa cells in rela …
MG132 (carbobenzoxy-Leu-Leu-leucinal) is a peptide aldehyde, which effectively blocks the proteolytic activity of the 26S proteaso …
Turning-ON Proteasomes.
Krahn JH, Kaschani F, Kaiser M. Krahn JH, et al. Cell Chem Biol. 2017 Jun 22;24(6):653-655. doi: 10.1016/j.chembiol.2017.06.005. Cell Chem Biol. 2017. PMID: 28644955 Free article.
While proteasome inhibitors are now well-established research tools and chemotherapeutics, proteasome activators are much less explored. In this issue of Cell Chemical Biology, in a study from the groups of Berkers and Ovaa (Leestemaker et al., …
While proteasome inhibitors are now well-established research tools and chemotherapeutics, proteasome activators are mu …
Molecular modeling of cationic porphyrin-anthraquinone hybrids as DNA topoisomerase IIβ inhibitors.
Arba M, Ruslin, Ihsan S, Tri Wahyudi S, Tjahjono DH. Arba M, et al. Comput Biol Chem. 2017 Dec;71:129-135. doi: 10.1016/j.compbiolchem.2017.10.002. Epub 2017 Oct 5. Comput Biol Chem. 2017. PMID: 29153891
Human DNA Topoisomerase II has been regarded as a promising target in anticancer drug discovery. ...First, we investigated the binding orientation of porphyrin hybrids into DNA topoisomerase IIbeta employing AutoDock 4.2 and then performed 20-ns …
Human DNA Topoisomerase II has been regarded as a promising target in anticancer drug discovery. ...First, we investiga …
Molecular modeling on porphyrin derivatives as β5 subunit inhibitor of 20S proteasome.
Arba M, Nur-Hidayat A, Ruslin, Yusuf M, Sumarlin, Hertadi R, Wahyudi ST, Surantaadmaja SI, Tjahjono DH. Arba M, et al. Comput Biol Chem. 2018 Jun;74:230-238. doi: 10.1016/j.compbiolchem.2018.03.002. Epub 2018 Apr 17. Comput Biol Chem. 2018. PMID: 29674291
In the present study, a series of porphyrin derivatives bearing either pyridine or pyrazole rings as meso-substituents were designed and evaluated as an inhibitor for the beta5 subunit of the proteasome by employing molecular docking and …
In the present study, a series of porphyrin derivatives bearing either pyridine or pyrazole rings as meso-substituents were de …
Structure-Activity Relationships of Thiazolyl Resorcinols, Potent and Selective Inhibitors of Human Tyrosinase.
Mann T, Scherner C, Röhm KH, Kolbe L. Mann T, et al. Int J Mol Sci. 2018 Feb 28;19(3):690. doi: 10.3390/ijms19030690. Int J Mol Sci. 2018. PMID: 29495618 Free PMC article.
Tyrosinase inhibitors are of great clinical interest as agents for the treatment of hyperpigmentary disorders; however, most compounds described in the literature lack clinical efficiency due to insufficient inhibitory activity against human tyrosinase …
Tyrosinase inhibitors are of great clinical interest as agents for the treatment of hyperpigmentary disorders; however, most compound …
Telomerase enzyme activation and human cell immortalization.
Meyerson M. Meyerson M. Toxicol Lett. 1998 Dec 28;102-103:41-5. doi: 10.1016/s0378-4274(98)00278-1. Toxicol Lett. 1998. PMID: 10022230 Review.
Activity of telomerase, the enzyme that synthesizes the telomere ends of linear eukaryotic chromosomes, is repressed in most normal human somatic cells but induced in most human cancers. Normal human cells that lack telomerase a …
Activity of telomerase, the enzyme that synthesizes the telomere ends of linear eukaryotic chromosomes, is repressed in most n …
Cationic porphyrin-based nanoparticles for photodynamic inactivation and identification of bacteria strains.
Li L, Wang Y, Huang T, He X, Zhang K, Kang ET, Xu L. Li L, et al. Biomater Sci. 2022 May 31;10(11):3006-3016. doi: 10.1039/d2bm00265e. Biomater Sci. 2022. PMID: 35522076
The as-obtained cationic porphyrin NPs preserved the photophysical properties of porphyrin derivatives, and can efficiently generate singlet oxygen ((1)O(2)) under 635 nm laser irradiation. The cationic porphyrin-based NPs displayed intri …
The as-obtained cationic porphyrin NPs preserved the photophysical properties of porphyrin derivatives, and can …
Proteasome inhibitors induce AMPK activation via CaMKKβ in human breast cancer cells.
Deshmukh RR, Dou QP. Deshmukh RR, et al. Breast Cancer Res Treat. 2015 Aug;153(1):79-88. doi: 10.1007/s10549-015-3512-2. Epub 2015 Jul 31. Breast Cancer Res Treat. 2015. PMID: 26227473
The purpose of present study is to examine the mechanism of the 5'-AMP-activated protein kinase (AMPK) activation induced by proteasome inhibitors. ...We observe that proteasome inhibition leads to AMPK activation in huma …
The purpose of present study is to examine the mechanism of the 5'-AMP-activated protein kinase (AMPK) activation induc …
33,534,710 results
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