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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 15
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1488
1843 1118
1844 1248
1845 1278
1846 1406
1847 1367
1848 1204
1849 1208
1850 1126
1851 1228
1852 1310
1853 1559
1854 1306
1855 1587
1856 1587
1857 1488
1858 1542
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1139
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1809
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2180
1878 2454
1879 2399
1880 2646
1881 3149
1882 2743
1883 3127
1884 3050
1885 3338
1886 3291
1887 3965
1888 4002
1889 4196
1890 4025
1891 3607
1892 4081
1893 4370
1894 3801
1895 4129
1896 4413
1897 4689
1898 4632
1899 4169
1900 3786
1901 3887
1902 3968
1903 3910
1904 4060
1905 4067
1906 3872
1907 4323
1908 4459
1909 4687
1910 4799
1911 5007
1912 4906
1913 5107
1914 5135
1915 4641
1916 4543
1917 4281
1918 4567
1919 4619
1920 4960
1921 4628
1922 4123
1923 4432
1924 4851
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5496
1932 5548
1933 5610
1934 5508
1935 5661
1936 5384
1937 5308
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4517
1944 4745
1945 20422
1946 53739
1947 64968
1948 70729
1949 62806
1950 85750
1951 103810
1952 108147
1953 108914
1954 105913
1955 108541
1956 107005
1957 111515
1958 109458
1959 109989
1960 112211
1961 120166
1962 125670
1963 141520
1964 162087
1965 176642
1966 179758
1967 191503
1968 207847
1969 215076
1970 218981
1971 222888
1972 227524
1973 230656
1974 234529
1975 248261
1976 250329
1977 249844
1978 258199
1979 265483
1980 267141
1981 271478
1982 283058
1983 294718
1984 302632
1985 318868
1986 331329
1987 347347
1988 363847
1989 377918
1990 383042
1991 380889
1992 382595
1993 390285
1994 401892
1995 411158
1996 421218
1997 418965
1998 436712
1999 453930
2000 491087
2001 503468
2002 521317
2003 548919
2004 591992
2005 650675
2006 697682
2007 733984
2008 781444
2009 821688
2010 884681
2011 960642
2012 1026793
2013 1077922
2014 1131946
2015 1174560
2016 1208721
2017 1232309
2018 1276920
2019 1337973
2020 1535575
2021 1679700
2022 1680039
2023 1593635
2024 1633969
2025 453696

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36,376,628 results

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Page 1
[Proteasome and proteasome inhibitors].
Meunier L, Stoebner PE, Marque M, Henry L, Bureau JP, Lavabre-Bertrand T. Meunier L, et al. Ann Dermatol Venereol. 2005 Nov;132(11 Pt 1):895-8. doi: 10.1016/s0151-9638(05)79510-7. Ann Dermatol Venereol. 2005. PMID: 16327721 Review. French. No abstract available.
Structural and functional insight into human O-GlcNAcase.
Roth C, Chan S, Offen WA, Hemsworth GR, Willems LI, King DT, Varghese V, Britton R, Vocadlo DJ, Davies GJ. Roth C, et al. Nat Chem Biol. 2017 Jun;13(6):610-612. doi: 10.1038/nchembio.2358. Epub 2017 Mar 27. Nat Chem Biol. 2017. PMID: 28346405 Free PMC article.
Through co-expression and assembly of OGA fragments, we determined the three-dimensional structure of human OGA, revealing an unusual helix-exchanged dimer that lays a structural foundation for an improved understanding of substrate recognition and regulation of OGA. ...
Through co-expression and assembly of OGA fragments, we determined the three-dimensional structure of human OGA, revealing an unusual …
A panel of subunit-selective activity-based proteasome probes.
Verdoes M, Willems LI, van der Linden WA, Duivenvoorden BA, van der Marel GA, Florea BI, Kisselev AF, Overkleeft HS. Verdoes M, et al. Org Biomol Chem. 2010 Jun 21;8(12):2719-27. doi: 10.1039/c001036g. Epub 2010 May 6. Org Biomol Chem. 2010. PMID: 20449511 Free PMC article.
Turning-ON Proteasomes.
Krahn JH, Kaschani F, Kaiser M. Krahn JH, et al. Cell Chem Biol. 2017 Jun 22;24(6):653-655. doi: 10.1016/j.chembiol.2017.06.005. Cell Chem Biol. 2017. PMID: 28644955 Free article.
While proteasome inhibitors are now well-established research tools and chemotherapeutics, proteasome activators are much less explored. ...
While proteasome inhibitors are now well-established research tools and chemotherapeutics, proteasome activators are much less …
Hyaluronidase inhibitors from Keiskea japonica.
Murata T, Miyase T, Yoshizaki F. Murata T, et al. Chem Pharm Bull (Tokyo). 2012;60(1):121-8. doi: 10.1248/cpb.60.121. Chem Pharm Bull (Tokyo). 2012. PMID: 22223383 Free article.
An extract of Keiskea japonica MIQ. showed an inhibitory effect on hyaluronidase activity. From the extract, four new phenylpropanoids, two new maltol glycosides, two new monoterpene glycosides, and two new phenolic compounds were isolated together with 19 known com …
An extract of Keiskea japonica MIQ. showed an inhibitory effect on hyaluronidase activity. From the extract, four new phenylpr …
Interaction of EGLIN C variants with the extended subsites of the precursor processing proteases.
Komiyama T. Komiyama T. Protein Pept Lett. 2005 Jul;12(5):415-20. doi: 10.2174/0929866054395220. Protein Pept Lett. 2005. PMID: 16029153 Review.
Potent inhibitors of the Kex2/furin family precursor processing proteases were developed by randomizing adventitious contact sites and screening for optimized affinity using inhibition assays in 96-well format [1]. In this review, the binding interactions of the dev …
Potent inhibitors of the Kex2/furin family precursor processing proteases were developed by randomizing adventitious contact sites and scree …
Synthesis and biological activities of novel artemisinin derivatives as cysteine protease falcipain-2 inhibitors.
Liu Y, Lu WQ, Cui KQ, Luo W, Wang J, Guo C. Liu Y, et al. Arch Pharm Res. 2012 Sep;35(9):1525-31. doi: 10.1007/s12272-012-0902-4. Epub 2012 Oct 9. Arch Pharm Res. 2012. PMID: 23054708
The target compounds were evaluated for inhibition activity against Plasmodium falciparum falcipain-2 in vitro, and most of them exhibited potent inhibition in the low micromolar range and proved to be new types of falcipain-2 inhibitors....
The target compounds were evaluated for inhibition activity against Plasmodium falciparum falcipain-2 in vitro, and most of th …
Novel ways to prevent proteolysis - prophytepsin and proplasmepsin II.
Bernstein NK, James MN. Bernstein NK, et al. Curr Opin Struct Biol. 1999 Dec;9(6):684-9. doi: 10.1016/s0959-440x(99)00030-5. Curr Opin Struct Biol. 1999. PMID: 10607668 Review.
The recently determined crystal structures of two aspartic proteinase zymogens, prophytepsin from barley and proplasmepsin II from the malarial parasite Plasmodium falciparum, have provided new insights into zymogen inactivation. Prophytepsin shows a variation of the mecha …
The recently determined crystal structures of two aspartic proteinase zymogens, prophytepsin from barley and proplasmepsin II from th …
36,376,628 results
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