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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 3
1950 1
1951 2
1952 1
1955 4
1957 1
1958 4
1959 19
1960 25
1961 73
1962 168
1963 262
1964 299
1965 303
1966 203
1967 275
1968 274
1969 290
1970 299
1971 398
1972 376
1973 366
1974 405
1975 207
1976 171
1977 163
1978 196
1979 239
1980 227
1981 304
1982 338
1983 381
1984 423
1985 413
1986 376
1987 352
1988 394
1989 434
1990 410
1991 468
1992 486
1993 450
1994 561
1995 636
1996 625
1997 685
1998 693
1999 748
2000 861
2001 925
2002 1013
2003 1201
2004 1259
2005 1345
2006 1523
2007 1587
2008 1671
2009 1731
2010 1793
2011 1943
2012 2032
2013 2122
2014 2061
2015 2047
2016 2001
2017 1896
2018 1805
2019 889
2020 17
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42,618 results
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Page 1
Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation.
Moda-Sava RN, et al. Science 2019. PMID 30975859 Free PMC article.
Antidepressant-dose ketamine reversed these effects by selectively rescuing eliminated spines and restoring coordinated activity in multicellular ensembles that predict motivated escape behavior. Prefrontal spinogenesis was required for the long-term maintenance of antidepressant effects on motivated escape behavior but not for their initial induction....
Antidepressant-dose ketamine reversed these effects by selectively rescuing eliminated spines and restoring coordinated activity in m
Ketamine: A Paradigm Shift for Depression Research and Treatment
Krystal JH, et al. Neuron 2019 - Review. PMID 30844397 Free PMC article.
Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. ...Neurobiological insights into ketamine efficacy shed new light on the mechanisms underlying antidepressant efficacy....
Ketamine is the first exemplar of a rapid-acting antidepressant with efficacy for treatment-resistant symptoms of mood disorders. ... …
Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study.
Popova V, et al. Am J Psychiatry 2019 - Clinical Trial. PMID 31109201
This study compared the efficacy and safety of switching patients with treatment-resistant depression from an ineffective antidepressant to flexibly dosed esketamine nasal spray plus a newly initiated antidepressant or to a newly initiated antidepressant (active comparator) plus placebo nasal spray. ...Confirmed nonresponders were randomly assigned to treatment with esketamine nasal spray (56 or 84 mg twice weekly) and an antidepressant or antidepressant and placebo nasal spray. ...
This study compared the efficacy and safety of switching patients with treatment-resistant depression from an ineffective antidepressant
Prognosis and improved outcomes in major depression: a review
Kraus C, et al. Transl Psychiatry 2019 - Review. PMID 30944309 Free PMC article.
Novel rapid-acting antidepressants, such as ketamine, may also constitute a paradigm shift in treatment optimization for MDD....
Novel rapid-acting antidepressants, such as ketamine, may also constitute a paradigm shift in treatment optimization for MDD....
[Irritable Bowel Syndrome]
Kim JH and Jee SR. Korean J Gastroenterol 2019 - Review. PMID 30845384 Korean. Free article.
Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments
Duman RS, et al. Neuron 2019 - Review. PMID 30946828 Free PMC article.
While current antidepressants have significant time lag and efficacy limitations, new rapid-acting agents that target the glutamate and GABA systems address these issues and offer superior therapeutic interventions for this widespread and debilitating disorder....
While current antidepressants have significant time lag and efficacy limitations, new rapid-acting agents that target the glutamate a …
Psychotropics and the Microbiome: a Chamber of Secrets…
Cussotto S, et al. Psychopharmacology (Berl) 2019 - Review. PMID 30806744 Free PMC article.
In this review, we will first give a comprehensive introduction about this bidirectional interaction, then we will take into consideration different classes of psychotropics including antipsychotics, antidepressants, antianxiety drugs, anticonvulsants/mood stabilisers, opioid analgesics, drugs of abuse, alcohol, nicotine and xanthines. ...
In this review, we will first give a comprehensive introduction about this bidirectional interaction, then we will take into consideration d …
42,618 results
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