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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 3
1948 2
1950 3
1952 1
1953 1
1954 1
1955 7
1956 1
1957 4
1958 8
1959 12
1960 8
1961 14
1962 9
1963 14
1964 19
1965 7
1966 2
1967 12
1968 1
1969 12
1970 63
1971 358
1972 783
1973 956
1974 900
1975 1065
1976 890
1977 976
1978 987
1979 912
1980 976
1981 915
1982 899
1983 962
1984 904
1985 1001
1986 1056
1987 1166
1988 1001
1989 1001
1990 1032
1991 1047
1992 1045
1993 1054
1994 939
1995 917
1996 791
1997 773
1998 768
1999 710
2000 735
2001 734
2002 663
2003 619
2004 678
2005 707
2006 744
2007 791
2008 684
2009 789
2010 843
2011 845
2012 789
2013 768
2014 757
2015 684
2016 626
2017 597
2018 554
2019 255
2020 5
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39,583 results
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Page 1
WDFY4 is required for cross-presentation in response to viral and tumor antigens.
Theisen DJ, et al. Science 2018. PMID 30409884 Free PMC article.
During the process of cross-presentation, viral or tumor-derived antigens are presented to CD8(+) T cells by Batf3-dependent CD8α(+)/XCR1(+) classical dendritic cells (cDC1s). We designed a functional CRISPR screen for previously unknown regulators of cross-presentation, and identified the BEACH domain-containing protein WDFY4 as essential for cross-presentation of cell-associated antigens by cDC1s in mice. ...
During the process of cross-presentation, viral or tumor-derived antigens are presented to CD8(+) T cells by Batf3-dependent CD8α(+)/ …
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Simoni Y, et al. Nature 2018. PMID 29769722
Here we show that human lung and colorectal cancer CD8(+) TILs can not only be specific for tumour antigens (for example, neoantigens), but also recognize a wide range of epitopes unrelated to cancer (such as those from Epstein-Barr virus, human cytomegalovirus or influenza virus). ...Our results demonstrate that not all tumour-infiltrating T cells are specific for tumour antigens, and suggest that measuring CD39 expression could be a straightforward way to quantify or isolate bystander T cells....
Here we show that human lung and colorectal cancer CD8(+) TILs can not only be specific for tumour antigens (for example, neoantigens …
Molecular mimicry and autoimmunity
Rojas M, et al. J Autoimmun 2018 - Review. PMID 30509385 Free article.
Nevertheless, studies on the role of autoreactive T-cells that are generated secondary to molecular mimicry, the diversity of the T-cell receptor repertoires of auto-reactive T-cells, the role of exposure to cryptic antigens, the generation of autoimmune B-cell responses, the interaction of microbiota and chemical adjuvants with the host immune systems all provide clues in advancing our understanding of the molecular mechanisms involved in the evolving concept of molecular mimicry and also may potentially aid in the prevention and treatment of autoimmune diseases....
Nevertheless, studies on the role of autoreactive T-cells that are generated secondary to molecular mimicry, the diversity of the T-cell rec …
Natural killer cell specificity for viral infections
Hammer Q, et al. Nat Immunol 2018 - Review. PMID 30026479
In this Review, we discuss the numerous modes for the specific recognition of viral antigens and peptides by NK cells and the implications of this for the composition of the NK cell repertoire as well as for the the selection of viral variants....
In this Review, we discuss the numerous modes for the specific recognition of viral antigens and peptides by NK cells and the implica …
Lactobacillus Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens.
LeCureux JS and Dean GA. mSphere 2018 - Review. PMID 29769376 Free PMC article.
The ability of LAB to elicit an immune response against expressed foreign antigens has led to their exploration as potential mucosal vaccine candidates. ...This article reviews Lactobacillus vaccine constructs, including Lactobacillus species, antigen expression, model organisms, and in vivo immune responses, with a primary focus on viral and bacterial antigens....
The ability of LAB to elicit an immune response against expressed foreign antigens has led to their exploration as potential mucosal …
Nanoparticle vaccines against viral infections
Sulczewski FB, et al. Arch Virol 2018 - Review. PMID 29728911
Several factors have contributed to the current lack of effective vaccines, including the high rate of viral mutation, low immunogenicity of recombinant viral antigens, instability of viral antigenic proteins administered in vivo, sophisticated mechanisms of viral immune evasion, and inefficient induction of mucosal immunity by vaccine models studied to date. ...
Several factors have contributed to the current lack of effective vaccines, including the high rate of viral mutation, low immunogenicity of …
T cells in patients with narcolepsy target self-antigens of hypocretin neurons.
Latorre D, et al. Nature 2018. PMID 30232458
Autoreactive CD4(+) T cells were polyclonal, targeted multiple epitopes, were restricted primarily by HLA-DR and did not cross-react with influenza antigens. ...
Autoreactive CD4(+) T cells were polyclonal, targeted multiple epitopes, were restricted primarily by HLA-DR and did not cross-react with in …
B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen
Hong S, et al. Immunity 2018. PMID 30291027 Free article.
B cells can present antigens to CD4(+) T cells, but it is thought that dendritic cells (DCs) are the primary initiators of naive CD4(+) T cell responses. ...
B cells can present antigens to CD4(+) T cells, but it is thought that dendritic cells (DCs) are the primary initiators of naive CD4( …
Evaluation of a viral DNA-protein immunization strategy against African swine fever in domestic pigs
Pérez-Núñez D, et al. Vet Immunol Immunopathol 2019. PMID 30712790 Free article.
ASFV is a large DNA virus that encodes for more than 150 proteins, thus making the identification of viral antigens that induce a protective immune response difficult. ...The ability of antibodies from pigs immunized with various combinations of ASFV-specific antigens to neutralize infection in vitro, and antigen-specific activation of the cellular immune response were analyzed....
ASFV is a large DNA virus that encodes for more than 150 proteins, thus making the identification of viral antigens that induce a pro …
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