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Year Number of Results
1991 6
1992 17
1993 20
1994 20
1995 26
1996 27
1997 30
1998 29
1999 29
2000 41
2001 30
2002 38
2003 29
2004 38
2005 46
2006 25
2007 32
2008 45
2009 42
2010 61
2011 58
2012 49
2013 59
2014 38
2015 41
2016 43
2017 35
2018 34
2019 11
2020 0
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913 results
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Page 1
Apolipoprotein A-I mimetics.
Reddy ST, et al. Curr Opin Lipidol 2014 - Review. PMID 24977978 Free PMC article.
PURPOSE OF REVIEW: To summarize recent publications in the field of apolipoprotein mimetics. RECENT FINDINGS: Apolipoprotein mimetic peptides continue to show efficacy in a number of animal models of disease and demonstrate properties that make them attractive as potential therapeutic agents. A number of new apolipoprotein mimetics have been described recently. A major site of action of apolipoprotein mimetic peptides was found to be in the small intestine in which they decrease the levels of proinflammatory bioactive lipids. ...
PURPOSE OF REVIEW: To summarize recent publications in the field of apolipoprotein mimetics. RECENT FINDINGS: Apolipoprotein m …
Supramolecular Organization of Apolipoprotein-A-I-Derived Peptides within Disc-like Arrangements.
Salnikov ES, et al. Biophys J 2018. PMID 30054032 Free PMC article.
Apolipoprotein A-I is the major protein component of high-density lipoproteins and fulfils important functions in lipid metabolism. ...Here, we investigated the lipid interactions of two apolipoprotein-A-I-derived class A amphipathic peptides, 14A (Ac-DYLKA FYDKL KEAF-NH(2)) and 18A (Ac-DWLKA FYDKV AEKLK EAF- NH(2)), including the disc-like supramolecular structures they form with phospholipids. ...
Apolipoprotein A-I is the major protein component of high-density lipoproteins and fulfils important functions in lipid metabolism. .
Apolipoprotein A-I attenuates LL-37-induced endothelial cell cytotoxicity.
Svensson D, et al. Biochem Biophys Res Commun 2017. PMID 28919413
Apolipoprotein A-I (ApoA-I) is a plasma protein endowed with atheroprotective effects. Here, we investigate the interaction between ApoA-I and LL-37 by biochemical techniques, and furthermore assess if ApoA-I protects against LL-37-evoked cytotoxicity in human umbilical vein endothelial cells (HUVEC). ...
Apolipoprotein A-I (ApoA-I) is a plasma protein endowed with atheroprotective effects. Here, we investigate the interaction between A
A model of lipid-free apolipoprotein A-I revealed by iterative molecular dynamics simulation.
Zhang X, et al. PLoS One 2015. PMID 25793886 Free PMC article.
Apolipoprotein A-I (apo A-I), the major protein component of high-density lipoprotein, has been proven inversely correlated to cardiovascular risk in past decades. ...
Apolipoprotein A-I (apo A-I), the major protein component of high-density lipoprotein, has been proven inversely correlated to cardio
Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin.
Townsend D, et al. J Biol Chem 2018. PMID 29853648 Free PMC article.
Amyloid deposits of WT apolipoprotein A-I (apoA-I), the main protein component of high-density lipoprotein, accumulate in atherosclerotic plaques where they may contribute to coronary artery disease by increasing plaque burden and instability. ...
Amyloid deposits of WT apolipoprotein A-I (apoA-I), the main protein component of high-density lipoprotein, accumulate in atheroscler …
Structural properties of apolipoprotein A-I mimetic peptides that promote ABCA1-dependent cholesterol efflux.
Islam RM, et al. Sci Rep 2018. PMID 29440748 Free PMC article.
Peptides mimicking the major protein of highdensity lipoprotein (HDL), apolipoprotein A-I (apoA-I), are promising therapeutics for cardiovascular diseases. ...
Peptides mimicking the major protein of highdensity lipoprotein (HDL), apolipoprotein A-I (apoA-I), are promising therapeutics for ca …
Tertiary structure of apolipoprotein A-I in nascent high-density lipoproteins.
Pourmousa M, et al. Proc Natl Acad Sci U S A 2018. PMID 29712830 Free PMC article.
Understanding the function of high-density lipoprotein (HDL) requires detailed knowledge of the structure of its primary protein, apolipoprotein A-I (APOA1). ...
Understanding the function of high-density lipoprotein (HDL) requires detailed knowledge of the structure of its primary protein, apolipo
Structures of apolipoprotein A-I in high density lipoprotein generated by electron microscopy and biased simulations.
Zhu L, et al. Biochim Biophys Acta Gen Subj 2017. PMID 28754383
BACKGROUND: Apolipoprotein A-I (apoA-I) in high-density lipoprotein (HDL) is a key protein for the transport of cholesterol from the vascular wall to the liver. ...Low resolution electron density maps were next used as restraints in biased Monte Carlo simulations of apolipoprotein A-I dimers, with an initial structure derived from atomic resolution X-ray structures. ...
BACKGROUND: Apolipoprotein A-I (apoA-I) in high-density lipoprotein (HDL) is a key protein for the transport of cholesterol from the …
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