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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 17
1986 32
1987 27
1988 39
1989 31
1990 51
1991 68
1992 79
1993 60
1994 66
1995 65
1996 65
1997 54
1998 62
1999 51
2000 46
2001 50
2002 24
2003 37
2004 37
2005 26
2006 26
2007 40
2008 26
2009 25
2010 26
2011 21
2012 25
2013 21
2014 22
2015 34
2016 38
2017 25
2018 26
2019 6
2020 0
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1,294 results
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Page 1
Familial defective apolipoprotein B-100: A review.
Andersen LH, et al. J Clin Lipidol 2016 - Review. PMID 27919345
Familial defective apolipoprotein B-100 (FDB) is an autosomal dominant genetic disorder of lipid metabolism associated with hyperlipidemia and elevated risk for atherosclerosis. FDB is caused by mutations in APOB reducing the binding affinity between apolipoprotein B-100 and the low-density lipoprotein receptor. ...
Familial defective apolipoprotein B-100 (FDB) is an autosomal dominant genetic disorder of lipid metabolism associated with hy …
Structural comparison of human apolipoproteins B-48 and B-100.
Hardman DA, et al. Biochemistry 1987. PMID 3676265
In this study we have investigated the structural relationship between human apolipoproteins B-48 and B-100 by comparing protein structure and by comparing nucleotide sequence from intestinal and hepatic cDNA clones. ...The resulting patterns suggest that B-48 is extensively homologous with the amino-terminal portion of B-100. We have identified only four peptides from B-48 (at least one in each digest) that are absent from the parallel digests of B-100. ...
In this study we have investigated the structural relationship between human apolipoproteins B-48 and B-100 by comparin …
Recent progress in understanding apolipoprotein B.
Young SG. Circulation 1990 - Review. PMID 1977530
Apo B-48 contains the amino-terminal 2,152 amino acids of apo B-100 and is produced by the intestine as a result of editing of a single nucleotide of the apo B mRNA, which changes the codon specifying apo B-100 amino acid 2,153 to a premature stop codon. ...Both apo B-48 and apo B-100 are encoded on chromosome 2 by a single gene that contains 29 exons and 28 introns. An elevated level of apo B-100 in the plasma is a potent risk factor for developing premature atherosclerotic disease. ...
Apo B-48 contains the amino-terminal 2,152 amino acids of apo B-100 and is produced by the intestine as a result of editing of …
[Apolipoprotein B].
Itakura H and Matsumoto A. Nihon Rinsho 1994 - Review. PMID 7853698 Japanese.
The gene encoding human apo B has been mapped to the short arm of chromosome 2 in the p23-p24 region. The apo B gene extends over 43 kb and is composed of 29 exons and 28 introns. Both apo B 100 and apo B 48 were encoded by the same gene. All intestinal cDNA clones contained a single C to T base substitution in the codon CAA encoding Gln2153 in apo B 100 cDNA, resulting in a translational stop. ...
The gene encoding human apo B has been mapped to the short arm of chromosome 2 in the p23-p24 region. The apo B gene extends o …
Synthesis and secretion of hepatic apolipoprotein B-containing lipoproteins.
Yao Z and McLeod RS. Biochim Biophys Acta 1994 - Review. PMID 8180241
Human apolipoprotein (apo) B-100 is required for the synthesis and secretion of hepatic triacyglycerol-rich lipoproteins. This review summarizes recent developments in understanding the interaction of cis-acting DNA sequences and trans-acting protein factors in regulation of apo B gene expression and apo B mRNA editing, and the role of structural determinants of apo B-100 in the assembly and secretion of hepatic lipoproteins. ...The relationship between apo B length and its ability to recruit lipids is presented, and the involvement of factors other than apo B in hepatic triacylglycerol-rich lipoprotein production is discussed....
Human apolipoprotein (apo) B-100 is required for the synthesis and secretion of hepatic triacyglycerol-rich lipoproteins. This …
Apolipoprotein B levels, APOB alleles, and risk of ischemic cardiovascular disease in the general population, a review.
Benn M. Atherosclerosis 2009 - Review. PMID 19200547
Apolipoprotein B is a key component in lipid metabolism. Subendothelial retention of apolipoprotein B containing lipoproteins is a necessary initiating event in atherogenesis, and high plasma levels of apolipoprotein B is a risk factor for atherosclerosis, whereas low levels may provide protection. The present review examines, with focus on general population studies, apolipoprotein B levels as a predictor of ischemic cardiovascular disease, as well as the association of mutations and polymorphisms in APOB with plasma apolipoprotein B levels, and risk of ischemic cardiovascular disease. ...
Apolipoprotein B is a key component in lipid metabolism. Subendothelial retention of apolipoprotein B containing
Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.
Innerarity TL, et al. J Lipid Res 1990 - Review. PMID 2280177 Free article.
Familial defective apolipoprotein B-100 is a genetic disorder of apolipoprotein B-100 that causes moderate to severe hypercholesterolemia. A single amino acid mutation in apolipoprotein B diminishes the ability of low density lipoproteins to bind to the low density lipoprotein receptor. ...
Familial defective apolipoprotein B-100 is a genetic disorder of apolipoprotein B-100 that causes moderate to se …
Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population
Gu QL, et al. Braz J Med Biol Res 2017. PMID 28902930 Free PMC article.
We investigated the influence of apolipoprotein B gene (APOB) variants on the risk of hyperlipidemia (HL) in 631 middle-aged and elderly members of the Chinese Yugur population (HL, n=336; normolipidemia, n=295). ...
We investigated the influence of apolipoprotein B gene (APOB) variants on the risk of hyperlipidemia (HL) in 631 middle-aged a …
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