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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 23
1986 42
1987 41
1988 51
1989 47
1990 67
1991 96
1992 110
1993 86
1994 94
1995 102
1996 107
1997 90
1998 103
1999 91
2000 84
2001 84
2002 50
2003 63
2004 74
2005 59
2006 63
2007 86
2008 60
2009 71
2010 69
2011 66
2012 80
2013 69
2014 67
2015 83
2016 89
2017 78
2018 68
2019 16
2020 1
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2,385 results
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Page 1
Abetalipoproteinemia and homozygous hypobetalipoproteinemia: a framework for diagnosis and management
Lee J and Hegele RA. J Inherit Metab Dis 2014 - Review. PMID 24288038
The root cause of both disorders is improper packaging and secretion of apolipoprotein (apo) B-containing lipoprotein particles due to mutations either in both alleles of the MTP (alias MTTP) gene encoding microsomal triglyceride transfer protein (MTP) or both alleles of the APOB gene itself in the case of ABL and HHBL, respectively. Clinical diagnosis is based on signs and symptoms, acanthocytosis on blood smear, and virtually absent apo B-containing lipoproteins, including chylomicrons, very low density lipoprotein and low density lipoprotein. ...
The root cause of both disorders is improper packaging and secretion of apolipoprotein (apo) B-containing lipoprotein particle …
Complex genetic architecture in severe hypobetalipoproteinemia
Wang LR, et al. Lipids Health Dis 2018. PMID 29540175 Free PMC article.
METHODS: A 43 year-old male had a longstanding severe deficiency of apolipoprotein (apo) B-containing lipoproteins and circulating fat soluble vitamins consistent with either abetalipoproteinemia or homozygous familial hypobetalipoproteinemia (FHBL). ...
METHODS: A 43 year-old male had a longstanding severe deficiency of apolipoprotein (apo) B-containing lipoproteins and circula …
Structural comparison of human apolipoproteins B-48 and B-100.
Hardman DA, et al. Biochemistry 1987. PMID 3676265
In this study we have investigated the structural relationship between human apolipoproteins B-48 and B-100 by comparing protein structure and by comparing nucleotide sequence from intestinal and hepatic cDNA clones. ...The resulting patterns suggest that B-48 is extensively homologous with the amino-terminal portion of B-100. We have identified only four peptides from B-48 (at least one in each digest) that are absent from the parallel digests of B-100. ...
In this study we have investigated the structural relationship between human apolipoproteins B-48 and B-100 by comparin …
Clinical and biochemical characteristics of individuals with low cholesterol syndromes: A comparison between familial hypobetalipoproteinemia and familial combined hypolipidemia
Di Costanzo A, et al. J Clin Lipidol 2017. PMID 28733173
BACKGROUND: The most frequent monogenic causes of low plasma cholesterol are familial hypobetalipoproteinemia (FHBL1) because of truncating mutations in apolipoprotein B coding gene (APOB) and familial combined hypolipidemia (FHBL2) due to loss-of-function mutations in ANGPTL3 gene. ...Mutations impairing liver synthesis or secretion of apolipoprotein B are crucial to increase the risk of liver steatosis....
BACKGROUND: The most frequent monogenic causes of low plasma cholesterol are familial hypobetalipoproteinemia (FHBL1) because of truncating …
The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis.
Hao Y, et al. Lipids Health Dis 2018. PMID 30119683 Free PMC article.
BACKGROUND: The objective of this study was to evaluate whether apolipoprotein gene polymorphisms confer susceptibility to osteonecrosis of the femoral head (ONFH). ...
BACKGROUND: The objective of this study was to evaluate whether apolipoprotein gene polymorphisms confer susceptibility to osteonecro …
The evolution of apolipoprotein B and its mRNA editing complex. Does the lack of editing contribute to hypertriglyceridemia?
Damsteegt EL, et al. Gene 2018. PMID 29031774
The evolution of apolipoprotein B (Apob) has been intensely researched due to its importance during lipid transport. Mammalian full-length apob100 can be post-transcriptionally edited by the enzyme apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like complex-one (Apobec1) resulting in a truncated Apob, known as Apob48. ...
The evolution of apolipoprotein B (Apob) has been intensely researched due to its importance during lipid transport. Mammalian …
Association of APOB and LIPC polymorphisms with type 2 diabetes in Chinese Han population
Long T, et al. Gene 2018. PMID 29883758
BACKGROUND: Apolipoprotein B (APOB), and hepatic lipase (LIPC) genes have been shown to play a key role in lipid metabolism in type 2 diabetes (T2D). ...
BACKGROUND: Apolipoprotein B (APOB), and hepatic lipase (LIPC) genes have been shown to play a key role in lipid metabolism in …
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