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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1983 1
1984 55
1985 137
1986 176
1987 160
1988 175
1989 205
1990 227
1991 221
1992 235
1993 235
1994 201
1995 291
1996 264
1997 286
1998 291
1999 251
2000 265
2001 243
2002 249
2003 227
2004 244
2005 204
2006 267
2007 263
2008 271
2009 223
2010 294
2011 279
2012 289
2013 266
2014 228
2015 246
2016 242
2017 190
2018 174
2019 67
2020 1
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7,607 results
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Page 1
Distinct metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein(a).
Diffenderfer MR, et al. Metabolism 2016. PMID 26975530 Free PMC article.
OBJECTIVES: Lipoprotein(a) [Lp(a)] is mainly similar in composition to LDL, but differs in having apolipoprotein (apo) (a) covalently linked to apoB-100. Our purpose was to examine the individual metabolism of apo(a) and apoB-100 within plasma Lp(a). MATERIALS AND METHODS: The kinetics of apo(a) and apoB-100 in plasma Lp(a) were assessed in four men with dyslipidemia [Lp(a) concentration: 8.9-124.7nmol/L]. ...
OBJECTIVES: Lipoprotein(a) [Lp(a)] is mainly similar in composition to LDL, but differs in having apolipoprotein (apo) (a) covalently …
Soft Drusen in Age-Related Macular Degeneration: Biology and Targeting Via the Oil Spill Strategies
Curcio CA. Invest Ophthalmol Vis Sci 2018 - Review. PMID 30357336 Free PMC article.
This review focuses on soft drusen/BLinD, summarizing evidence that a major ultrastructural component is large apolipoprotein B,E-containing, cholesterol-rich lipoproteins secreted by the retinal pigment epithelium (RPE) that offload unneeded lipids of dietary and outer segment origin to create an atherosclerosis-like progression in the subRPE-basal lamina space. ...
This review focuses on soft drusen/BLinD, summarizing evidence that a major ultrastructural component is large apolipoprotein B
The metabolism of lipoprotein (a): an ever-evolving story.
Reyes-Soffer G, et al. J Lipid Res 2017 - Review. PMID 28720561 Free PMC article.
Lipoprotein (a) [Lp(a)] is characterized by apolipoprotein (a) [apo(a)] covalently bound to apolipoprotein B 100. It was described in human plasma by Berg et al. in 1963 and the gene encoding apo(a) (LPA) was cloned in 1987 by Lawn and colleagues. ...In this review, we highlight past and recent data from stable isotope studies of Lp(a) metabolism, highlighting the critical metabolic uncertainties that exist. ...
Lipoprotein (a) [Lp(a)] is characterized by apolipoprotein (a) [apo(a)] covalently bound to apolipoprotein B 100. It wa …
Lipid transfer proteins in the assembly of apoB-containing lipoproteins
Sirwi A and Hussain MM. J Lipid Res 2018 - Review. PMID 29650752 Free PMC article.
Assembly is aided by cell death-inducing DFF45-like effector B and by phospholipid transfer protein, which may facilitate additional deposition of triacylglycerols and phospholipids, respectively, to apoB. Here, we summarize the current understanding of the different steps in the assembly of B-lps and discuss the role of lipid transfer proteins in these steps to help identify new clinical targets for lipid-associated disorders, such as heart disease....
Assembly is aided by cell death-inducing DFF45-like effector B and by phospholipid transfer protein, which may facilitate additional …
Apolipoprotein B metabolism: tracer kinetics, models, and metabolic studies.
Burnett JR and Barrett PH. Crit Rev Clin Lab Sci 2002 - Review. PMID 12014529
The study of apolipoprotein (apo) B metabolism is central to our understanding of lipoprotein metabolism. However, the assembly and secretion of apoB-containing lipoproteins is a complex process. ...The purpose of this review is to examine the role of apoB in lipoprotein metabolism and to explore the applications of kinetic analysis and multicompartmental modeling to the study of apoB metabolism. ...
The study of apolipoprotein (apo) B metabolism is central to our understanding of lipoprotein metabolism. Howeve …
PCSK9 Association With Lipoprotein(a)
Tavori H, et al. Circ Res 2016. PMID 27121620 Free PMC article.
RATIONALE: Lipoprotein(a) [Lp(a)] is a highly atherogenic low-density lipoprotein-like particle characterized by the presence of apoprotein(a) [apo(a)] bound to apolipoprotein B. ...OBJECTIVE: Characterize the association of PCSK9 and Lp(a) in 39 subjects with high Lp(a) levels (range 39-320 mg/dL) and in transgenic mice expressing either human apo(a) only or human Lp(a) (via coexpression of human apo(a) and human apolipoprotein B). ...
RATIONALE: Lipoprotein(a) [Lp(a)] is a highly atherogenic low-density lipoprotein-like particle characterized by the presence of apoprotein( …
Determination of apolipoproteins B-48 and B-100 in triglyceride-rich lipoproteins by analytical SDS-PAGE.
Karpe F and Hamsten A. J Lipid Res 1994. PMID 7964192 Free article.
The present work describes a procedure for determining apolipoproteins (apo) B-100 and B-48 in subfractions of triglyceride-rich lipoproteins by analytical sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) with Coomassie staining. ...The precision of this analytical SDS-PAGE-based procedure to determine the plasma concentrations of apoB-100 and B-48 in triglyceride-rich lipoproteins was found to be appreciably low (coefficients of variation ranging between 3.1 and 14.1%)....
The present work describes a procedure for determining apolipoproteins (apo) B-100 and B-48 in subfractions of triglyce …
Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications
Tabas I, et al. Circulation 2007 - Review. PMID 17938300
The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein B-containing lipoproteins. Local biological responses to these retained lipoproteins, including a chronic and maladaptive macrophage- and T-cell-dominated inflammatory response, promote subsequent lesion development. The most effective therapy against atherothrombotic cardiovascular disease to date--low density lipoprotein-lowering drugs--is based on the principle that decreasing circulating apolipoprotein B lipoproteins decreases the probability that they will enter and be retained in the subendothelium. ...
The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein B-containing lipoproteins. Local …
Studies of apolipoprotein B-100 metabolism using radiotracers and stable isotopes.
Demant T and Packard CJ. Eur J Pediatr 1997 - Review. PMID 9266221
Apolipoprotein B metabolism can be investigated in-vivo either by exogenous radiolabeling of preformed lipoproteins or by endogenous labelling of denovo synthesized apo B using a stable isotope substituted amino acid tracer. ...
Apolipoprotein B metabolism can be investigated in-vivo either by exogenous radiolabeling of preformed lipoproteins or
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