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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 15
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 279
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 409
1829 568
1830 510
1831 579
1832 284
1833 221
1834 209
1835 222
1836 220
1837 281
1838 265
1839 289
1840 395
1841 829
1842 971
1843 813
1844 609
1845 589
1846 561
1847 542
1848 549
1849 486
1850 508
1851 573
1852 571
1853 657
1854 481
1855 717
1856 702
1857 709
1858 784
1859 705
1860 786
1861 608
1862 591
1863 517
1864 635
1865 569
1866 823
1867 1025
1868 1132
1869 1204
1870 1132
1871 1176
1872 1389
1873 1372
1874 1226
1875 1168
1876 1174
1877 1206
1878 1321
1879 1297
1880 1489
1881 1740
1882 1314
1883 1930
1884 1952
1885 2139
1886 2229
1887 2725
1888 2672
1889 3089
1890 2703
1891 2375
1892 2882
1893 3261
1894 2853
1895 3053
1896 3355
1897 3496
1898 3541
1899 3203
1900 3095
1901 3193
1902 3302
1903 3397
1904 3577
1905 3630
1906 3551
1907 3851
1908 4203
1909 4505
1910 4562
1911 4772
1912 4710
1913 4995
1914 5008
1915 4484
1916 4299
1917 4054
1918 4078
1919 4440
1920 5037
1921 4703
1922 4193
1923 4519
1924 4945
1925 5058
1926 5397
1927 5945
1928 5537
1929 5798
1930 5694
1931 5572
1932 5629
1933 5695
1934 5577
1935 5736
1936 5448
1937 5378
1938 5829
1939 5616
1940 5024
1941 4865
1942 4800
1943 4543
1944 4764
1945 20490
1946 53909
1947 65017
1948 70703
1949 62796
1950 85769
1951 103731
1952 108069
1953 108904
1954 105914
1955 108544
1956 107007
1957 111522
1958 109458
1959 109963
1960 112141
1961 120106
1962 125637
1963 141522
1964 162087
1965 176650
1966 179759
1967 191553
1968 207865
1969 215038
1970 218979
1971 222895
1972 227481
1973 230659
1974 234550
1975 248276
1976 251228
1977 252517
1978 261296
1979 268940
1980 270194
1981 274339
1982 286089
1983 298033
1984 306089
1985 322468
1986 335285
1987 351563
1988 368282
1989 382611
1990 388988
1991 387545
1992 389659
1993 397992
1994 409368
1995 419418
1996 429920
1997 428026
1998 446292
1999 464252
2000 501582
2001 514601
2002 532793
2003 561127
2004 604655
2005 664120
2006 710731
2007 748789
2008 796993
2009 836347
2010 899495
2011 973574
2012 1039102
2013 1092348
2014 1145601
2015 1186675
2016 1214686
2017 1232632
2018 1271091
2019 1326077
2020 1512046
2021 1496871
2022 10172
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Article type
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Search Results

31,785,044 results
Results by year
Filters applied: . Clear all Quoted phrases not found: "(cyclohexane Carbonyl) 1 Methyl 2 Oxospiro[indoline 3", "6 (4chlorobenzyl) 1h Spiro[imidazo[1", "5 C]thiazole 3", "5 C)thiazole 3", "Drug Megadose"
Page 1
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA. Vassilev LT, et al. Science. 2004 Feb 6;303(5659):844-8. doi: 10.1126/science.1092472. Epub 2004 Jan 2. Science. 2004. PMID: 14704432
MDM2 binds the p53 tumor suppressor protein with high affinity and negatively modulates its transcriptional activity and stability. ...These compounds bind MDM2 in the p53-binding pocket and activate the p53 pathway i
MDM2 binds the p53 tumor suppressor protein with high affinity and negatively modulates its transcription
Reactivation of p53 gene by MDM2 inhibitors: A novel therapy for cancer treatment.
Gupta A, Shah K, Oza MJ, Behl T. Gupta A, et al. Biomed Pharmacother. 2019 Jan;109:484-492. doi: 10.1016/j.biopha.2018.10.155. Epub 2018 Nov 6. Biomed Pharmacother. 2019. PMID: 30551517 Free article. Review.
Cancer is an uncontrolled and abnormal growth of cells in the body. Gene that guards the cell cycle and function as tumor suppressor is p53 (also called as the guardian of the genome) which is encoded by the TP53 gene. ...
Cancer is an uncontrolled and abnormal growth of cells in the body. Gene that guards the cell cycle and function
LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity.
Wu G, Cai J, Han Y, Chen J, Huang ZP, Chen C, Cai Y, Huang H, Yang Y, Liu Y, Xu Z, He D, Zhang X, Hu X, Pinello L, Zhong D, He F, Yuan GC, Wang DZ, Zeng C. Wu G, et al. Circulation. 2014 Oct 21;130(17):1452-1465. doi: 10.1161/CIRCULATIONAHA.114.011675. Epub 2014 Aug 25. Circulation. 2014. PMID: 25156994 Free PMC article.
Through loss- and gain-of-function approaches, we showed that lincRNA-p21 represses cell proliferation and induces apoptosis in vascular smooth muscle cells and mouse mononuclear macrophage cells in vitro. ...Genome-wide analysis r …
Through loss- and gain-of-function approaches, we showed that lincRNA-p21 represses cell proliferation and induces apoptosi
Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression.
Li Y, Yang J, Aguilar A, McEachern D, Przybranowski S, Liu L, Yang CY, Wang M, Han X, Wang S. Li Y, et al. J Med Chem. 2019 Jan 24;62(2):448-466. doi: 10.1021/acs.jmedchem.8b00909. Epub 2018 Dec 10. J Med Chem. 2019. PMID: 30525597 Free PMC article.
Human murine double minute 2 (MDM2) protein is a primary endogenous cellular inhibitor of the tumor suppressor p53 and has been pursued as an attractive cancer therapeutic target. ...It achieves an IC(50) value of 1.
Human murine double minute 2 (MDM2) protein is a primary endogenous cellular inhibitor of the tumor su
Chemopreventive Agent 3,3'-Diindolylmethane Inhibits MDM2 in Colorectal Cancer Cells.
Gao X, Liu J, Cho KB, Kedika S, Guo B. Gao X, et al. Int J Mol Sci. 2020 Jun 30;21(13):4642. doi: 10.3390/ijms21134642. Int J Mol Sci. 2020. PMID: 32629830 Free PMC article.
Mouse double minute 2 homolog (MDM2) is an important, multi-functional oncogenic protein and it has been well recognized for its negative regulation of the tumor suppressor protein p53. ...When combined with imidazoline M
Mouse double minute 2 homolog (MDM2) is an important, multi-functional oncogenic protein and it has been well re
P53 mdm2 inhibitors.
Khoury K, Dömling A. Khoury K, et al. Curr Pharm Des. 2012;18(30):4668-78. doi: 10.2174/138161212802651580. Curr Pharm Des. 2012. PMID: 22650254 Free PMC article. Review.
The protein-protein interaction (PPI) between p53 and its negative regulator MDM2 comprises one of the most important and intensely studied PPI's involved in preventing the initiation of cancer. ...Due to the Angstrom level structural insight th …
The protein-protein interaction (PPI) between p53 and its negative regulator MDM2 comprises one of the most impo …
Small-molecule MDM2-p53 inhibitors: recent advances.
Zhang B, Golding BT, Hardcastle IR. Zhang B, et al. Future Med Chem. 2015;7(5):631-45. doi: 10.4155/fmc.15.13. Future Med Chem. 2015. PMID: 25921402 Review.
Potent and selective small-molecule inhibitors of the p53-MDM2 interaction intended for the treatment of p53 wild-type tumors have been designed and optimized in a number of chemical series. This review details recent disclosures of compo …
Potent and selective small-molecule inhibitors of the p53-MDM2 interaction intended for the treatment of …
Inhibition of p53 inhibitors: progress, challenges and perspectives.
Sanz G, Singh M, Peuget S, Selivanova G. Sanz G, et al. J Mol Cell Biol. 2019 Jul 19;11(7):586-599. doi: 10.1093/jmcb/mjz075. J Mol Cell Biol. 2019. PMID: 31310659 Free PMC article. Review.
p53 is the major tumor suppressor and the most frequently inactivated gene in cancer. p53 could be disabled either by mutations or by upstream negative regulators, including, but not limited to MDM2 and MDMX. p53 activity is
p53 is the major tumor suppressor and the most frequently inactivated gene in cancer. p53 could be disabl
Inhibitory effects of salidroside on MCF-7 breast cancer cells in vivo.
Sun AQ, Ju XL. Sun AQ, et al. J Int Med Res. 2020 Nov;48(11):300060520968353. doi: 10.1177/0300060520968353. J Int Med Res. 2020. PMID: 33238796 Free PMC article.
Bcl-1, p53, Bax, and caspase 3 expression in tumor tissues was determined via western blotting. ...CONCLUSIONS: Salidroside was more effective than paclitaxel in inhibiting tumor growth in MCF-7 b …
Bcl-1, p53, Bax, and caspase 3 expression in tumor tissues was determined via western bl
Recent Small-Molecule Inhibitors of the p53-MDM2 Protein-Protein Interaction.
Beloglazkina A, Zyk N, Majouga A, Beloglazkina E. Beloglazkina A, et al. Molecules. 2020 Mar 7;25(5):1211. doi: 10.3390/molecules25051211. Molecules. 2020. PMID: 32156064 Free PMC article. Review.
This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the p53- Mouse double minute 2 homolog (MDM2) protein-protein interaction. The main focus is placed on …
This review presents the last decade of studies on the synthesis of various types of small-molecule inhibitors of the …
31,785,044 results
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