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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 3
1961 2
1962 2
1963 1
1987 2
1988 3
1989 10
1990 28
1991 48
1992 77
1993 153
1994 365
1995 590
1996 939
1997 1301
1998 1830
1999 2455
2000 3139
2001 3709
2002 3876
2003 4583
2004 5035
2005 5305
2006 5985
2007 6405
2008 6517
2009 6746
2010 6910
2011 7279
2012 7624
2013 7803
2014 7562
2015 7593
2016 7083
2017 6494
2018 6187
2019 2890
2020 70
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113,224 results
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Page 1
Bax, Bak and beyond - mitochondrial performance in apoptosis.
Peña-Blanco A and García-Sáez AJ. FEBS J 2018 - Review. PMID 28755482 Free article.
Bax and Bak are members of the Bcl-2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they are activated and oligomerize at the mitochondrial outer membrane (MOM) to mediate its permeabilization, which is considered a key step in apoptosis. ...Finally, we consider the contribution of mitochondrial composition, dynamics and interaction with other organelles to apoptosis commitment. ...
Bax and Bak are members of the Bcl-2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they a …
BCL-2 family proteins: changing partners in the dance towards death
Kale J, et al. Cell Death Differ 2018 - Review. PMID 29149100 Free PMC article.
The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activation and apoptosis. ...Finally, we discuss how post-translational modifications and differing intracellular localizations alter the mechanisms of apoptosis regulation by BCL-2 family proteins. ...
The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeab …
Autophagy and apoptosis: where do they meet?
Mukhopadhyay S, et al. Apoptosis 2014 - Review. PMID 24415198
Cellular stress causes the displacement of Bcl-2 from Beclin-1 and Bax, thereby triggering autophagy and apoptosis, respectively. ...Moreover, autophagic proteins that control nucleation and elongation regulate intrinsic apoptosis through calpain- and caspase-mediated cleavage of autophagy-related proteins, which switches the cellular program from autophagy to apoptosis. ...
Cellular stress causes the displacement of Bcl-2 from Beclin-1 and Bax, thereby triggering autophagy and apoptosis, respectively. ... …
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.
Czabotar PE, et al. Nat Rev Mol Cell Biol 2014 - Review. PMID 24355989
The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell suicide programme that is essential for development, tissue homeostasis and immunity. Too little apoptosis can promote cancer and autoimmune diseases; too much apoptosis can augment ischaemic conditions and drive neurodegeneration. ...
The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell suicide programme that is essential for dev …
The BCL-2 arbiters of apoptosis and their growing role as cancer targets.
Adams JM and Cory S. Cell Death Differ 2018 - Review. PMID 29099483 Free PMC article.
Impaired apoptosis plays a central role in cancer development and limits the efficacy of conventional cytotoxic therapies. Deepening understanding of how opposing factions of the BCL-2 protein family switch on apoptosis and of their structures has driven development of a new class of cancer drugs that targets various pro-survival members by mimicking their natural inhibitors, the BH3-only proteins. ...This review sketches the impact of the BCL-2 family on cancer development and therapy, describes how interactions of family members trigger apoptosis and discusses the potential of BH3 mimetic drugs to advance cancer therapy....
Impaired apoptosis plays a central role in cancer development and limits the efficacy of conventional cytotoxic therapies. Deepening …
The Beclin 1 network regulates autophagy and apoptosis.
Kang R, et al. Cell Death Differ 2011 - Review. PMID 21311563 Free PMC article.
Interestingly, caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy. Beclin 1 dysfunction has been implicated in many disorders, including cancer and neurodegeneration. Here, we summarize new findings regarding the organization and function of the Beclin 1 network in cellular homeostasis, focusing on the cross-regulation between apoptosis and autophagy....
Interestingly, caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy. Beclin 1 dysfunction has bee …
Apoptosis regulatory protein-protein interaction demonstrates hierarchical scale-free fractal network.
Nafis S, et al. Brief Bioinform 2015. PMID 25256288
Here we used the network theory methods, using experimentally validated 25 apoptosis regulatory proteins and identified important genes for apoptosis regulation, which demonstrated a hierarchical scale-free fractal protein-protein interaction network. ...Apart from TP53, BRCA1 was observed to regulate apoptosis by influencing motif, propagation of signals and module regulation, reflecting their biological significance. ...
Here we used the network theory methods, using experimentally validated 25 apoptosis regulatory proteins and identified important gen …
Oncogenic Role of Tumor Necrosis Factor α-Induced Protein 8 (TNFAIP8)
Niture S, et al. Cells 2018 - Review. PMID 30586922 Free PMC article.
In human cancers, TNFAIP8 promotes cell proliferation, invasion, metastasis, drug resistance, autophagy, and tumorigenesis by inhibition of cell apoptosis. ...
In human cancers, TNFAIP8 promotes cell proliferation, invasion, metastasis, drug resistance, autophagy, and tumorigenesis by inhibition of …
The Life and Death of a Plant Cell
Kabbage M, et al. Annu Rev Plant Biol 2017 - Review. PMID 28125285
We also discuss the implications of the paradox that is functional conservation of apoptotic hallmarks in plants in the absence of core mammalian apoptosis regulators, what that means, and whether an equivalent form of death occurs in plants....
We also discuss the implications of the paradox that is functional conservation of apoptotic hallmarks in plants in the absence of core mamm …
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