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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 2
1948 2
1950 2
1951 5
1952 7
1953 6
1954 5
1955 1
1956 4
1957 9
1958 28
1959 29
1960 43
1961 35
1962 31
1964 5
1965 3
1974 1
1977 2
1978 2
1979 3
1980 9
1981 281
1982 385
1983 427
1984 649
1985 762
1986 785
1987 736
1988 600
1989 594
1990 660
1991 675
1992 646
1993 648
1994 679
1995 617
1996 627
1997 625
1998 552
1999 526
2000 538
2001 504
2002 455
2003 461
2004 455
2005 467
2006 443
2007 414
2008 381
2009 390
2010 378
2011 405
2012 353
2013 359
2014 320
2015 329
2016 343
2017 277
2018 232
2019 112
2020 1
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18,503 results
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Page 1
Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases.
Sonnweber T, et al. Int J Mol Sci 2018 - Review. PMID 30360467 Free PMC article.
Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. ...
Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in th
The eicosapentaenoic acid:arachidonic acid ratio and its clinical utility in cardiovascular disease.
Nelson JR and Raskin S. Postgrad Med 2019 - Review. PMID 31063407
Eicosapentaenoic acid (EPA) is a key anti-inflammatory/anti-aggregatory long-chain polyunsaturated omega-3 fatty acid. Conversely, the omega-6 fatty acid, arachidonic acid (AA) is a precursor to a number of pro-inflammatory/pro-aggregatory mediators. ...
Eicosapentaenoic acid (EPA) is a key anti-inflammatory/anti-aggregatory long-chain polyunsaturated omega-3 fatty acid. Convers …
Omega-6 fatty acids and inflammation
Innes JK and Calder PC. Prostaglandins Leukot Essent Fatty Acids 2018 - Review. PMID 29610056
In humans on a Western diet, the omega-6 polyunsaturated fatty acid arachidonic acid (ARA) makes a significant contribution to the fatty acids present in the membrane phospholipids of cells involved in inflammation. ...Hence, it is commonly believed that increasing dietary intake of the omega-6 fatty acids ARA or its precursor linoleic acid (LA) will increase inflammation. ...
In humans on a Western diet, the omega-6 polyunsaturated fatty acid arachidonic acid (ARA) makes a significant contribu …
Fatty acid transport protein 2 reprograms neutrophils in cancer.
Veglia F, et al. Nature 2019. PMID 30996346 Free PMC article.
Here we report that mouse and human PMN-MDSCs exclusively upregulate fatty acid transport protein 2 (FATP2). Overexpression of FATP2 in PMN-MDSCs was controlled by granulocyte-macrophage colony-stimulating factor, through the activation of the STAT5 transcription factor. ...The main mechanism of FATP2-mediated suppressive activity involved the uptake of arachidonic acid and the synthesis of prostaglandin E(2). ...
Here we report that mouse and human PMN-MDSCs exclusively upregulate fatty acid transport protein 2 (FATP2). Overexpression of FATP2 …
Differentiating the biological effects of linoleic acid from arachidonic acid in health and disease.
Burns JL, et al. Prostaglandins Leukot Essent Fatty Acids 2018 - Review. PMID 30103919
This review explores the literature surrounding the combined and individual roles of n-6 PUFAs linoleic acid (LA) and arachidonic acid (AA) as they relate to immune and inflammatory response, cardiovascular health, liver health, and cancer. ...
This review explores the literature surrounding the combined and individual roles of n-6 PUFAs linoleic acid (LA) and arachidonic
Docosahexaenoic acid (DHA) and arachidonic acid (ARA) balance in developmental outcomes.
Colombo J, et al. Prostaglandins Leukot Essent Fatty Acids 2017 - Clinical Trial. PMID 28651697 Free PMC article.
The trial contrasted the effects of four formulations: 0.00% docosahexaenoic acid (DHA)/0.00% arachidonic acid (ARA), 0.32% DHA/0.64% ARA, 0.64% DHA/0.64% ARA, and 0.96% DHA/0.64% ARA against a control condition (0.00% DHA/0.00% ARA). ...
The trial contrasted the effects of four formulations: 0.00% docosahexaenoic acid (DHA)/0.00% arachidonic acid (ARA), 0 …
Arachidonic Acid Metabolism and Kidney Inflammation.
Wang T, et al. Int J Mol Sci 2019 - Review. PMID 31357612 Free PMC article.
As a major component of cell membrane lipids, Arachidonic acid (AA), being a major component of the cell membrane lipid content, is mainly metabolized by three kinds of enzymes: cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP450) enzymes. ...In addition, AA can regulate renal ion transport through 19-hydroxystilbenetetraenoic acid (19-HETE) and 20-HETE, both of which are produced by cytochrome P450 monooxygenase. ...
As a major component of cell membrane lipids, Arachidonic acid (AA), being a major component of the cell membrane lipid conten …
Minimizing Membrane Arachidonic Acid Content as a Strategy for Controlling Cancer: A Review.
McCarty MF and DiNicolantonio JJ. Nutr Cancer 2018 - Review. PMID 30273003
Many cancers and pre-cancerous lesions convert membrane-bound arachidonic acid (AA) to eicosanoids that promote the survival, growth, and spread of cancer. ...The former goal can be achieved by eating a plant-based diet (inherently free of AA); by avoiding foods high in linoleic acid; by down-regulating the expression of delta-6-desaturase (D6D), rate-limiting for the conversion of linoleic acid to AA; and by competitively decreasing flux of linoleic acid through D6D with a high intake of alpha-linolenic acid (ALA) from flaxseed. ...
Many cancers and pre-cancerous lesions convert membrane-bound arachidonic acid (AA) to eicosanoids that promote the survival, …
Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA(2) balance.
Thomas MH, et al. Alzheimers Res Ther 2017. PMID 28851448 Free PMC article.
METHODS: Two groups of 39 adult male BALB/c mice were fed with an arachidonic acid-enriched diet or an oleic acid-enriched diet, respectively, for 12 weeks. ...In the cortex, the dietary arachidonic acid also induced an increase of arachidonic acid-containing phospholipid species in phosphatidylserine class, whereas intracerebroventricular injections modified several arachidonic acid- and docosahexaenoic acid-containing species in the four phospholipid classes. ...
METHODS: Two groups of 39 adult male BALB/c mice were fed with an arachidonic acid-enriched diet or an oleic acid-enric …
Arachidonic Acid and Nitroarachidonic: Effects on NADPH Oxidase Activity.
Gonzalez-Perilli L, et al. Adv Exp Med Biol 2019 - Review. PMID 31140173
Arachidonic acid (AA) is a polyunsaturated fatty acid that participates in the inflammatory response mainly through bioactive-lipids formation in macrophages and also in the phagocytic NADPH oxidase 2 (NOX2) activation. ...It has been demonstrated that NO(2)-AA forms a covalent adduct with PDI that could prevent the interaction with NOX2 and it would explain the inhibitory effects of the fatty acid upon NOX2. ...
Arachidonic acid (AA) is a polyunsaturated fatty acid that participates in the inflammatory response mainly through bio
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