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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 1
1957 2
1958 11
1959 11
1960 14
1961 9
1962 10
1978 1
1979 1
1981 1
1983 1
1985 1
1987 1
1989 2
1990 11
1991 202
1992 456
1993 446
1994 497
1995 409
1996 424
1997 444
1998 376
1999 352
2000 372
2001 332
2002 306
2003 303
2004 306
2005 303
2006 277
2007 260
2008 248
2009 247
2010 255
2011 259
2012 229
2013 255
2014 210
2015 208
2016 227
2017 182
2018 158
2019 81
2020 1
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8,144 results
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Page 1
The discovery and early structural studies of arachidonic acid.
Martin SA, et al. J Lipid Res 2016 - Review. PMID 27142391 Free PMC article.
Arachidonic acid and esterified arachidonate are ubiquitous components of every mammalian cell. This polyunsaturated fatty acid serves very important biochemical roles, including being the direct precursor of bioactive lipid mediators such as prostaglandin and leukotrienes. ...Herein, we review the findings leading up to the discovery of arachidonic acid and the progress toward its complete structural elucidation....
Arachidonic acid and esterified arachidonate are ubiquitous components of every mammalian cell. This polyunsaturated fatty
The Essentiality of Arachidonic Acid in Infant Development.
Hadley KB, et al. Nutrients 2016 - Review. PMID 27077882 Free PMC article.
Arachidonic acid (ARA, 20:4n-6) is an n-6 polyunsaturated 20-carbon fatty acid formed by the biosynthesis from linoleic acid (LA, 18:2n-6). ...
Arachidonic acid (ARA, 20:4n-6) is an n-6 polyunsaturated 20-carbon fatty acid formed by the biosynthesis from linoleic
Arachidonic Acid and Eicosapentaenoic Acid Metabolism in Juvenile Atlantic Salmon as Affected by Water Temperature.
Norambuena F, et al. PLoS One 2015. PMID 26599513 Free PMC article.
Aerobic scope increases and lipid metabolism changes are known plasticity responses of fish for a better acclimation to high water temperature. The present study aimed at investigating the effect of high water temperature on the regulation of fatty acid metabolism in juvenile Atlantic salmon fed different dietary ARA/EPA ratios (arachidonic acid, 20:4n-6/ eicosapentaenoic acid, 20:5n-3), with particular focus on apparent in vivo enzyme activities and gene expression of lipid metabolism pathways. ...
Aerobic scope increases and lipid metabolism changes are known plasticity responses of fish for a better acclimation to high water te …
Metabolism of arachidonic acid to eicosanoids within the nucleus.
Luo M, et al. Biochim Biophys Acta 2006 - Review. PMID 16574479
Many of the eicosanoids are produced from one polyunsaturated fatty acid, arachidonic acid. The diversity of possible products that can be synthesized from arachidonic acid is due, in part to the variety of enzymes that can act on it. ...The objectives of this commentary are to review what is known about the metabolism of arachidonic acid to eicosanoids within the nucleus and to point to important areas for future discovery....
Many of the eicosanoids are produced from one polyunsaturated fatty acid, arachidonic acid. The diversity of possible p …
Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology.
Fan F and Roman RJ. J Am Soc Nephrol 2017 - Review. PMID 28701518 Free PMC article.
Thirty-five years ago, a third pathway for the metabolism of arachidonic acid by cytochrome P450 enzymes emerged. Subsequent work revealed that 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids formed by these pathways have essential roles in the regulation of renal tubular and vascular function. ...However, the mechanisms involved remain controversial, especially for 20-hydroxyeicosatetraenoic acid, which has both vasoconstrictive and natriuretic actions. ...
Thirty-five years ago, a third pathway for the metabolism of arachidonic acid by cytochrome P450 enzymes emerged. Subse …
Arachidonic acid metabolism in airway epithelial cells.
Holtzman MJ. Annu Rev Physiol 1992 - Review. PMID 1562177
Recent discoveries include the facts that (a) airway epithelial cells contain abundant stores of fatty acid substrates, including arachidonic acid, for oxygenation, (b) the cells release arachidonic acid upon activation of specific phospholipases, (c) the cells contain novel cyclooxygenases and lipoxygenases at high levels relative to other cell types, and (d) some of the arachidonate metabolites have potent biologic effects on airway end organs such as smooth muscle, nerves, mucus glands, and epithelial cells themselves. ...Therefore, determining the factors that regulate arachidonic acid metabolism in airway epithelial cells is still a fundamental goal for unraveling the role of arachidonate products in airway function and for altering eicosanoid production in the airway....
Recent discoveries include the facts that (a) airway epithelial cells contain abundant stores of fatty acid substrates, including …
Dietary Linoleic Acid Lowering Reduces Lipopolysaccharide-Induced Increase in Brain Arachidonic Acid Metabolism.
Taha AY, et al. Mol Neurobiol 2017. PMID 27339880 Free PMC article.
Linoleic acid (LA, 18:2n-6) is a precursor to arachidonic acid (AA, 20:4n-6), which can be converted by brain lipoxygenase and cyclooxygenase (COX) enzymes into various lipid mediators involved in the regulation of brain immunity. Brain AA metabolism is activated in rodents by the bacterial endotoxin, lipopolysaccharide (LPS). This study tested the hypothesis that dietary LA lowering, which limits plasma supply of AA to the brain, reduces LPS-induced upregulation in brain AA metabolism. ...
Linoleic acid (LA, 18:2n-6) is a precursor to arachidonic acid (AA, 20:4n-6), which can be converted by brain lipoxygen …
Research/review: Insights into the mutation-induced dysfunction of arachidonic acid metabolism from modeling of human CYP2J2.
Xia XL, et al. Curr Drug Metab 2014 - Review. PMID 25204827
Some polymorphisms, e.g., CYP2J2 with mutation T143A, R158C, I192N or N404Y, could significantly reduce the metabolism of the arachidonic acid, causing or deteriorating the coronary artery disease. However, so far the detailed mechanism for the mutationinduced dysfunction of arachidonic metabolism is still unknown. To reveal its mechanism, a 3D (three-dimensional) structure for human CYP2J2 was developed, followed by docking the arachidonic acid ligand into the active site of the receptor. ...
Some polymorphisms, e.g., CYP2J2 with mutation T143A, R158C, I192N or N404Y, could significantly reduce the metabolism of the arac
Arachidonic acid metabolites and endothelial dysfunction of portal hypertension.
Sacerdoti D, et al. Prostaglandins Other Lipid Mediat 2015 - Review. PMID 26072731
Arachidonic acid (AA) metabolites through the three pathways, cyclooxygenase (COX), lipoxygenase, and cytochrome P450 monooxygenase and epoxygenase, are involved in endothelial dysfunction of portal hypertension. ...
Arachidonic acid (AA) metabolites through the three pathways, cyclooxygenase (COX), lipoxygenase, and cytochrome P450 monooxyg
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