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Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders.
Borges RL, González-Blanco G, Arigela H, Huang Y, Caeiro LD, Fattakhov N, Lepore S, Garcia-Martinez L, Maurice M, Mehta PD, Park EJ, MacGillivray K, Nehru J, Chau M, Robayo MC, Abad C, Bilbao-Martinez A, Monteiro F, Luo X, Tan S, Bilbao D, Sidoli S, Di Stefano B, Walz K, Saltzman AL, Verdun RE, Shiekhattar R, Morey L. Borges RL, et al. Among authors: arigela h. Mol Cell. 2026 Feb 19;86(4):604-624.e16. doi: 10.1016/j.molcel.2026.01.023. Epub 2026 Feb 6. Mol Cell. 2026. PMID: 41653922 Free PMC article.
Neuronal differentiation requires BRAT1 complex to remove REST from chromatin.
Dokaneheifard S, Gomes Dos Santos H, Guiselle Valencia M, Arigela H, Edupuganti RR, Shiekhattar R. Dokaneheifard S, et al. Among authors: arigela h. Proc Natl Acad Sci U S A. 2024 Jun 4;121(23):e2318740121. doi: 10.1073/pnas.2318740121. Epub 2024 May 28. Proc Natl Acad Sci U S A. 2024. PMID: 38805275 Free PMC article.