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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 14
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1488
1843 1118
1844 1248
1845 1277
1846 1406
1847 1367
1848 1203
1849 1207
1850 1126
1851 1228
1852 1310
1853 1558
1854 1306
1855 1586
1856 1587
1857 1488
1858 1542
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1138
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1809
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2179
1878 2454
1879 2399
1880 2646
1881 3149
1882 2742
1883 3126
1884 3049
1885 3337
1886 3291
1887 3965
1888 4002
1889 4194
1890 4024
1891 3607
1892 4080
1893 4370
1894 3801
1895 4129
1896 4412
1897 4689
1898 4631
1899 4169
1900 3785
1901 3886
1902 3967
1903 3910
1904 4059
1905 4067
1906 3872
1907 4323
1908 4459
1909 4687
1910 4799
1911 5006
1912 4906
1913 5105
1914 5135
1915 4640
1916 4543
1917 4281
1918 4567
1919 4619
1920 4960
1921 4628
1922 4123
1923 4432
1924 4851
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5496
1932 5548
1933 5610
1934 5508
1935 5661
1936 5384
1937 5308
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4517
1944 4745
1945 20421
1946 53739
1947 64968
1948 70726
1949 62805
1950 85750
1951 103810
1952 108147
1953 108914
1954 105913
1955 108541
1956 107005
1957 111515
1958 109458
1959 109989
1960 112210
1961 120166
1962 125670
1963 141520
1964 162087
1965 176641
1966 179753
1967 191497
1968 207843
1969 215073
1970 218975
1971 222872
1972 227509
1973 230627
1974 234510
1975 248224
1976 250212
1977 249483
1978 257798
1979 265073
1980 266816
1981 271171
1982 282711
1983 294296
1984 302230
1985 318407
1986 330853
1987 346753
1988 363034
1989 377025
1990 382157
1991 379945
1992 381494
1993 389239
1994 400697
1995 409850
1996 419676
1997 417244
1998 434686
1999 451827
2000 488271
2001 500721
2002 518695
2003 546239
2004 588272
2005 647198
2006 691994
2007 729808
2008 777264
2009 816901
2010 879734
2011 956207
2012 1022140
2013 1073153
2014 1127104
2015 1169450
2016 1203749
2017 1227613
2018 1271292
2019 1332409
2020 1528261
2021 1672891
2022 1674932
2023 1588946
2024 1631365
2025 1486891
2026 4265
2027 2

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37,240,925 results

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Quoted phrases not found in phrase index: "Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 1", "Priority Journal"
Page 1
ADP-ribosylation from molecular mechanisms to therapeutic implications.
Suskiewicz MJ, Prokhorova E, Rack JGM, Ahel I. Suskiewicz MJ, et al. Cell. 2023 Oct 12;186(21):4475-4495. doi: 10.1016/j.cell.2023.08.030. Cell. 2023. PMID: 37832523 Free PMC article. Review.
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life. ...In this review, we present the state-of-the-art findings covering the work in structural biology, bioc …
ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular …
A viral ADP-ribosyltransferase attaches RNA chains to host proteins.
Wolfram-Schauerte M, Pozhydaieva N, Grawenhoff J, Welp LM, Silbern I, Wulf A, Billau FA, Glatter T, Urlaub H, Jäschke A, Höfer K. Wolfram-Schauerte M, et al. Nature. 2023 Aug;620(7976):1054-1062. doi: 10.1038/s41586-023-06429-2. Epub 2023 Aug 16. Nature. 2023. PMID: 37587340 Free PMC article.
When bacteriophage T4 infects Escherichia coli, it uses three different adenosine diphosphate (ADP)-ribosyltransferases (ARTs) to reprogram the transcriptional and translational apparatus of the host by ADP-ribosylation using nicotinamide ade …
When bacteriophage T4 infects Escherichia coli, it uses three different adenosine diphosphate (ADP)-ribosyltransferases …
PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon gamma-induced ADP-ribosylation.
Ribeiro VC, Russo LC, Hoch NC. Ribeiro VC, et al. EMBO J. 2024 Jul;43(14):2908-2928. doi: 10.1038/s44318-024-00125-1. Epub 2024 Jun 4. EMBO J. 2024. PMID: 38834852 Free PMC article.
However, which ADP-ribosyltransferases mediate host ADP-ribosylation, what proteins and pathways they target and how these modifications affect viral infection and pathogenesis is currently unclear. Here we show that host ADP-ribosyltransferase activit …
However, which ADP-ribosyltransferases mediate host ADP-ribosylation, what proteins and pathways they target and how these mod …
PARP7 is a proteotoxic stress sensor that labels proteins for degradation.
Ikenga NJ, Vervoorts J, Lüscher B, Žaja R, Feijs-Žaja KLH. Ikenga NJ, et al. EMBO J. 2025 Oct;44(19):5463-5481. doi: 10.1038/s44318-025-00545-7. Epub 2025 Aug 20. EMBO J. 2025. PMID: 40836037 Free PMC article.
ADP-ribosylation is a post-translational modification that plays a critical role in cellular stress responses. We have observed that during proteotoxic stress, cellular ADP-ribosylation increases, with ADP-ribosylated proteins accumulating in cytoplasmic foci …
ADP-ribosylation is a post-translational modification that plays a critical role in cellular stress responses. We have observed that …
Inhibiting poly(ADP-ribosylation) improves axon regeneration.
Byrne AB, McWhirter RD, Sekine Y, Strittmatter SM, Miller DM, Hammarlund M. Byrne AB, et al. Elife. 2016 Oct 4;5:e12734. doi: 10.7554/eLife.12734. Elife. 2016. PMID: 27697151 Free PMC article.
Here, we identify novel intrinsic regulators of axon regeneration: poly(ADP-ribose) glycohodrolases (PARGs) and poly(ADP-ribose) polymerases (PARPs). PARGs, which remove poly(ADP-ribose) from proteins, act in injured C. eleg …
Here, we identify novel intrinsic regulators of axon regeneration: poly(ADP-ribose) glycohodrolases (PARGs) and poly( …
SnapShot: ADP-Ribosylation Signaling.
Hottiger MO. Hottiger MO. Mol Cell. 2015 Jun 18;58(6):1134-1134.e1. doi: 10.1016/j.molcel.2015.06.001. Mol Cell. 2015. PMID: 26091348 Free article.
Intracellular protein ADP-ribosylation is catalyzed by diphteria toxin-like ADP-ribosyltransferases (ARTDs, formerly PARPs) ("writers"), which use NAD(+) for the modification of different amino acids. While some ARTD members catalyze protein poly-ADP-ribosyla …
Intracellular protein ADP-ribosylation is catalyzed by diphteria toxin-like ADP-ribosyltransferases (ARTDs, formerly PARPs) (" …
Site-specific ADP-ribosylation of histone H2B in response to DNA double strand breaks.
Rakhimova A, Ura S, Hsu DW, Wang HY, Pears CJ, Lakin ND. Rakhimova A, et al. Sci Rep. 2017 Mar 2;7:43750. doi: 10.1038/srep43750. Sci Rep. 2017. PMID: 28252050 Free PMC article.
ADP-ribosyltransferases (ARTs) modify proteins with single units or polymers of ADP-ribose to regulate DNA repair. ...This identifies DNA damage induced histone mono-ADP-ribosylation sites by specific ARTs in vivo, providing a unique platform to assess …
ADP-ribosyltransferases (ARTs) modify proteins with single units or polymers of ADP-ribose to regulate DNA repair. ...T …
Thioredoxin 1 moonlights as a chaperone for an interbacterial ADP-ribosyltransferase toxin.
Dumont B, Terradot L, Cascales E, Van Melderen L, Jurėnas D. Dumont B, et al. Nat Commun. 2024 Nov 29;15(1):10388. doi: 10.1038/s41467-024-54892-w. Nat Commun. 2024. PMID: 39613764 Free PMC article.
We show that the activity of the secreted bacterial ADP-ribosyltransferase (ART) toxin TreX, which does not contain any cysteines, is dependent on TrxA. ...Our study therefore suggests that thioredoxin 1 evolved alternative functions by maintaining the intera …
We show that the activity of the secreted bacterial ADP-ribosyltransferase (ART) toxin TreX, which does not contain any cystei …
PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
Lindgren AE, Karlberg T, Thorsell AG, Hesse M, Spjut S, Ekblad T, Andersson CD, Pinto AF, Weigelt J, Hottiger MO, Linusson A, Elofsson M, Schüler H. Lindgren AE, et al. ACS Chem Biol. 2013 Aug 16;8(8):1698-703. doi: 10.1021/cb4002014. Epub 2013 Jun 25. ACS Chem Biol. 2013. PMID: 23742272
Here, we describe an inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3), a regulator of DNA repair and mitotic progression. ...Our results show that by targeting the nicotinamide binding site, selective inhibition can be …
Here, we describe an inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3), a regulator of …
Poly(ADP-ribose) polymerase-1 is a nuclear epigenetic regulator of mitochondrial DNA repair and transcription.
Lapucci A, Pittelli M, Rapizzi E, Felici R, Moroni F, Chiarugi A. Lapucci A, et al. Mol Pharmacol. 2011 Jun;79(6):932-40. doi: 10.1124/mol.110.070110. Epub 2011 Mar 11. Mol Pharmacol. 2011. PMID: 21441600
Poly(ADP-ribose) polymerase-1 (PARP-1) is a NAD-consuming enzyme with an emerging key role in epigenetic regulation of gene transcription. ...Here, we show that, despite exclusive nuclear localization of PARP-1, mitochondrial homeo …
Poly(ADP-ribose) polymerase-1 (PARP-1) is a NAD-consuming enzyme with an emerging key role in epigenetic …
37,240,925 results
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