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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 4
1975 6
1976 8
1977 9
1978 13
1979 25
1980 26
1981 16
1982 25
1983 28
1984 33
1985 47
1986 69
1987 86
1988 107
1989 132
1990 132
1991 130
1992 185
1993 191
1994 242
1995 204
1996 225
1997 239
1998 229
1999 245
2000 328
2001 322
2002 307
2003 304
2004 320
2005 333
2006 344
2007 362
2008 340
2009 330
2010 388
2011 449
2012 422
2013 463
2014 444
2015 472
2016 523
2017 530
2018 517
2019 214
2020 0
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9,447 results
Results by year
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Page 1
Epilepsy and astrocyte energy metabolism.
Boison D and Steinhäuser C. Glia 2018 - Review. PMID 29044647 Free PMC article.
Dysfunctional glutamate metabolism in astrocytes can directly contribute to neuronal hyperexcitability. Closure of astrocyte intercellular gap junction coupling as observed early during epileptogenesis limits activity-dependent trafficking of energy metabolites, but also impairs clearance of the extracellular space from accumulation of K(+) and glutamate. Dysfunctional astrocytes also increase the metabolism of adenosine, a metabolic product of ATP degradation that broadly inhibits energy-consuming processes as an evolutionary adaptation to conserve energy. ...
Dysfunctional glutamate metabolism in astrocytes can directly contribute to neuronal hyperexcitability. Closure of astrocyte i …
Normal aging induces A1-like astrocyte reactivity
Clarke LE, et al. Proc Natl Acad Sci U S A 2018. PMID 29437957 Free PMC article.
Detailed analysis of the differentially expressed genes in aging revealed that aged astrocytes take on a reactive phenotype of neuroinflammatory A1-like reactive astrocytes. Hippocampal and striatal astrocytes up-regulated a greater number of reactive astrocyte genes compared with cortical astrocytes. ...
Detailed analysis of the differentially expressed genes in aging revealed that aged astrocytes take on a reactive phenotype of neuroi …
Astrocytes and microglia: Models and tools.
Guttenplan KA and Liddelow SA. J Exp Med 2019 - Review. PMID 30541903 Free PMC article.
Here, we outline the pros and cons of in vivo and in vitro techniques to study astrocytes and microglia with the goal of helping researchers quickly identify the best approach for a given research question in the context of glial biology. ...
Here, we outline the pros and cons of in vivo and in vitro techniques to study astrocytes and microglia with the goal of helping rese …
Astrocyte activation and reactive gliosis
Pekny M and Nilsson M. Glia 2005 - Review. PMID 15846805
Astrocytes become activated (reactive) in response to many CNS pathologies, such as stroke, trauma, growth of a tumor, or neurodegenerative disease. ...The fact that astrocytes function as a syncytium of interconnected cells both in health and in disease, rather than as individual cells, adds yet another dimension to this picture. ...
Astrocytes become activated (reactive) in response to many CNS pathologies, such as stroke, trauma, growth of a tumor, or neurodegene
Bioenergetics and redox adaptations of astrocytes to neuronal activity.
Bolaños JP. J Neurochem 2016 - Review. PMID 26968531 Free PMC article.
Neuronal activity is a high-energy demanding process recruiting all neural cells that adapt their metabolism to sustain the energy and redox balance of neurons. During neurotransmission, synaptic cleft glutamate activates its receptors in neurons and in astrocytes, before being taken up by astrocytes through energy costly transporters. ...
Neuronal activity is a high-energy demanding process recruiting all neural cells that adapt their metabolism to sustain the energy an …
Neuronal activity induces glutathione metabolism gene expression in astrocytes.
McGann JC and Mandel G. Glia 2018. PMID 30043519 Free PMC article.
The idea that astrocytes provide support for neurons has a long history, but whether neurons play an instructive role in these processes is poorly understood. ...We find that numerous pathways are regulated in the co-cultured astrocytes, in a time-dependent matter coincident with synaptic maturation. ...
The idea that astrocytes provide support for neurons has a long history, but whether neurons play an instructive role in these proces …
In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons.
Mächler P, et al. Cell Metab 2016. PMID 26698914 Free article.
We monitored lactate in cortical astrocytes and neurons of mice using the genetically encoded FRET sensor Laconic in combination with two-photon microscopy. ...Trans-acceleration of the monocarboxylate transporter with pyruvate was able to reduce intracellular lactate in astrocytes but not in neurons. ...
We monitored lactate in cortical astrocytes and neurons of mice using the genetically encoded FRET sensor Laconic in combination with …
Heterogeneity of astrocytic form and function
Oberheim NA, et al. Methods Mol Biol 2012 - Review. PMID 22144298 Free PMC article.
Astrocytes participate in all essential CNS functions, including blood flow regulation, energy metabolism, ion and water homeostasis, immune defence, neurotransmission, and adult neurogenesis. ...Recent lines of work also show that the complexity of protoplasmic astrocytes increases during evolution. Human astrocytes are structurally more complex, larger, and propagate calcium signals significantly faster than rodent astrocytes. ...
Astrocytes participate in all essential CNS functions, including blood flow regulation, energy metabolism, ion and water homeo
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