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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 15
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1487
1843 1118
1844 1248
1845 1278
1846 1404
1847 1367
1848 1204
1849 1208
1850 1125
1851 1228
1852 1309
1853 1559
1854 1306
1855 1587
1856 1587
1857 1488
1858 1541
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1139
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1809
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2180
1878 2454
1879 2399
1880 2646
1881 3149
1882 2743
1883 3127
1884 3050
1885 3338
1886 3291
1887 3965
1888 4002
1889 4196
1890 4025
1891 3607
1892 4081
1893 4369
1894 3801
1895 4129
1896 4414
1897 4688
1898 4632
1899 4169
1900 3786
1901 3886
1902 3968
1903 3910
1904 4060
1905 4067
1906 3872
1907 4323
1908 4459
1909 4687
1910 4799
1911 5007
1912 4906
1913 5106
1914 5135
1915 4642
1916 4544
1917 4281
1918 4567
1919 4618
1920 4960
1921 4628
1922 4123
1923 4432
1924 4850
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5496
1932 5546
1933 5610
1934 5507
1935 5661
1936 5384
1937 5308
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4517
1944 4745
1945 20421
1946 53735
1947 64959
1948 70707
1949 62804
1950 85750
1951 103742
1952 108056
1953 108914
1954 105914
1955 108541
1956 107005
1957 111515
1958 109456
1959 109957
1960 112135
1961 120098
1962 125629
1963 141519
1964 162086
1965 176637
1966 179741
1967 191505
1968 207845
1969 215047
1970 218965
1971 222887
1972 227514
1973 230657
1974 234528
1975 248264
1976 250387
1977 249908
1978 258362
1979 265670
1980 267340
1981 271673
1982 283247
1983 294966
1984 302992
1985 319125
1986 331672
1987 347695
1988 364172
1989 378284
1990 383268
1991 380773
1992 382492
1993 391075
1994 402005
1995 411355
1996 421580
1997 419312
1998 437093
1999 454606
2000 491845
2001 504060
2002 521840
2003 549456
2004 592645
2005 651339
2006 698096
2007 734121
2008 781195
2009 820467
2010 883037
2011 956887
2012 1022837
2013 1073553
2014 1125861
2015 1167073
2016 1199007
2017 1219826
2018 1263398
2019 1320580
2020 1505954
2021 1644973
2022 1641430
2023 1551128
2024 1251744
2025 1330

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35,474,283 results

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Page 1
[Cell cycle, mitosis and therapeutic applications].
Levy A, Albiges-Sauvin L, Massard C, Soria JC, Deutsch E. Levy A, et al. Bull Cancer. 2011 Oct;98(9):1037-45. doi: 10.1684/bdc.2011.1382. Bull Cancer. 2011. PMID: 21669563 Free article. Review. French.
During the process of evolution, organisms have acquired a series of response mechanisms and repair of DNA damage, thereby ensuring the maintenance of genome stability and faithful transmission of genetic information. The checkpoints are the major mechanisms …
During the process of evolution, organisms have acquired a series of response mechanisms and repair of DNA damage, thereby ens …
The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.
Smith J, Tho LM, Xu N, Gillespie DA. Smith J, et al. Adv Cancer Res. 2010;108:73-112. doi: 10.1016/B978-0-12-380888-2.00003-0. Adv Cancer Res. 2010. PMID: 21034966 Review.
Cellular responses to DNA damage are coordinated primarily by two distinct kinase signaling cascades, the ATM-Chk2 and ATR-Chk1 pathways, which are activated by DNA double-strand breaks (DSBs) and single-stranded DNA respectively. ...Here, we review current u …
Cellular responses to DNA damage are coordinated primarily by two distinct kinase signaling cascades, the ATM-Chk2 and …
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ. Matsuoka S, et al. Science. 2007 May 25;316(5828):1160-6. doi: 10.1126/science.1140321. Science. 2007. PMID: 17525332
Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the signal transduction portion of this pathway are known, but lit …
Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiec …
Characterization of ATM gene mutations in 66 ataxia telangiectasia families.
Sandoval N, Platzer M, Rosenthal A, Dörk T, Bendix R, Skawran B, Stuhrmann M, Wegner RD, Sperling K, Banin S, Shiloh Y, Baumer A, Bernthaler U, Sennefelder H, Brohm M, Weber BH, Schindler D. Sandoval N, et al. Hum Mol Genet. 1999 Jan;8(1):69-79. doi: 10.1093/hmg/8.1.69. Hum Mol Genet. 1999. PMID: 9887333
The gene mutated in AT, designated the ATM gene, encodes a large protein kinase with a PI-3 kinase-related domain. In this study, we investigated the mutational spectrum of the ATM gene in a cohort of AT patients living in Germany. ...One of these muta …
The gene mutated in AT, designated the ATM gene, encodes a large protein kinase with a PI-3 kinase-related domain. In this stu …
USP10 regulates p53 localization and stability by deubiquitinating p53.
Yuan J, Luo K, Zhang L, Cheville JC, Lou Z. Yuan J, et al. Cell. 2010 Feb 5;140(3):384-96. doi: 10.1016/j.cell.2009.12.032. Epub 2010 Jan 21. Cell. 2010. PMID: 20096447 Free PMC article.
Here, we report that USP10, a cytoplasmic ubiquitin-specific protease, deubiquitinates p53, reversing Mdm2-induced p53 nuclear export and degradation. After DNA damage, USP10 is stabilized, and a fraction of USP10 translocates to the nucleus to activate p53. The tra …
Here, we report that USP10, a cytoplasmic ubiquitin-specific protease, deubiquitinates p53, reversing Mdm2-induced p53 nuclear export and de …
The genetic defect in ataxia-telangiectasia.
Lavin MF, Shiloh Y. Lavin MF, et al. Annu Rev Immunol. 1997;15:177-202. doi: 10.1146/annurev.immunol.15.1.177. Annu Rev Immunol. 1997. PMID: 9143686 Review.
The autosomal recessive human disorder ataxia-telangiectasia (A-T) was first described as a separate disease entity 40 years ago. ...Greater insight into the nature of the defect in A-T has been provided by the recent identification, by positional cloning, of …
The autosomal recessive human disorder ataxia-telangiectasia (A-T) was first described as a separate disease entity 40 …
The ATM gene and ataxia telangiectasia.
Mavrou A, Tsangaris GT, Roma E, Kolialexi A. Mavrou A, et al. Anticancer Res. 2008 Jan-Feb;28(1B):401-5. Anticancer Res. 2008. PMID: 18383876 Free article. Review.
Ataxia telangiectasia (AT) is a rare neurodegenerative, autosomal recessive disorder characterized by chromosome instability, radiosensitivity, immunodeficiency and a predisposition for cancer. ...The disease is caused by mutations in the ATM gene, lea …
Ataxia telangiectasia (AT) is a rare neurodegenerative, autosomal recessive disorder characterized by chromosome instability, …
MicroRNAs and DNA damage response: implications for cancer therapy.
Wang Y, Taniguchi T. Wang Y, et al. Cell Cycle. 2013 Jan 1;12(1):32-42. doi: 10.4161/cc.23051. Epub 2012 Dec 19. Cell Cycle. 2013. PMID: 23255103 Free PMC article. Review.
The DNA damage response (DDR) pathways play critical roles in protecting the genome from DNA damage. ...The expression levels of some miRNAs change in response to DNA damage. Some miRNAs, such as miR-24, 138, 96 and 182, have been implica …
The DNA damage response (DDR) pathways play critical roles in protecting the genome from DNA damage. ...The expr …
ATM and the molecular pathogenesis of ataxia telangiectasia.
McKinnon PJ. McKinnon PJ. Annu Rev Pathol. 2012;7:303-21. doi: 10.1146/annurev-pathol-011811-132509. Epub 2011 Oct 24. Annu Rev Pathol. 2012. PMID: 22035194 Review.
Ataxia telangiectasia (A-T) results from inactivation of the ATM protein kinase. DNA-damage signaling is a prime function of this kinase, although other roles have been ascribed to ATM. ...Together with A-T, these syndromes indicat …
Ataxia telangiectasia (A-T) results from inactivation of the ATM protein kinase. DNA-damage signal …
ATM protein kinase: the linchpin of cellular defenses to stress.
Bhatti S, Kozlov S, Farooqi AA, Naqi A, Lavin M, Khanna KK. Bhatti S, et al. Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2. Cell Mol Life Sci. 2011. PMID: 21533982 Free PMC article. Review.
Any damage done to DNA relentlessly challenges the cellular machinery involved in recognition, processing and repair of these insults. ATM kinase is activated early to detect and signal lesions in DNA, arrest the cell cycle, establish DNA repair signaling and …
Any damage done to DNA relentlessly challenges the cellular machinery involved in recognition, processing and repair of these insults. AT …
35,474,283 results
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