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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1971 2
1972 3
1973 1
1974 2
1975 4
1976 4
1977 7
1978 8
1979 4
1980 6
1981 2
1982 6
1983 2
1984 5
1985 7
1986 7
1987 13
1988 12
1989 8
1990 4
1991 4
1992 8
1993 11
1994 7
1995 9
1996 7
1997 9
1998 7
1999 7
2000 12
2001 15
2002 20
2003 15
2004 22
2005 29
2006 54
2007 51
2008 52
2009 54
2010 51
2011 63
2012 56
2013 64
2014 56
2015 52
2016 59
2017 51
2018 41
2019 20
2020 0
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887 results
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Page 1
Abnormal mTOR Activation in Autism
Winden KD, et al. Annu Rev Neurosci 2018 - Review. PMID 29490194
Abnormalities in this pathway have been identified in several syndromes in which autism spectrum disorder (ASD) is highly prevalent. Several studies have investigated mTOR signaling in developmental and neuronal processes that, when dysregulated, could contribute to the development of ASD. ...
Abnormalities in this pathway have been identified in several syndromes in which autism spectrum disorder (ASD) is highly prevalent. …
Vitamin D, neurosteroids and autism.
Máčová L, et al. Physiol Res 2017 - Review. PMID 28948817 Free article.
Vitamin D had been for a long time investigated for its effects on bone metabolism. Recently has been observed that the incidence of some neurodevelopmental disorders (including autism) increases hand in hand with vitamin D deficiency. ...In our review we focused on potential connections among vitamin D, steroids and autism. Potential mechanisms of vitamin D action are also discussed....
Vitamin D had been for a long time investigated for its effects on bone metabolism. Recently has been observed that the incidence of …
Fragile X mental retardation 1 gene enhances the translation of large autism-related proteins
Greenblatt EJ and Spradling AC. Science 2018. PMID 30115809 Free PMC article.
Human homologs of at least 20 targets are associated with dominant intellectual disability, and 30 others with recessive neurodevelopmental dysfunction. Stored oocytes lacking FMR1 usually generate embryos with severe neural defects, unlike stored wild-type oocytes, which suggests that translation of multiple large proteins by stored mRNAs is defective in fragile X syndrome and possibly other autism spectrum disorders....
Human homologs of at least 20 targets are associated with dominant intellectual disability, and 30 others with recessive neuro …
Widespread RNA editing dysregulation in brains from autistic individuals.
Tran SS, et al. Nat Neurosci 2019. PMID 30559470 Free PMC article.
Transcriptomic analyses of postmortem brains have begun to elucidate molecular abnormalities in autism spectrum disorder (ASD). ...Our findings, which are corroborated across multiple data sets, including dup15q (genomic duplication of 15q11.2-13.1) cases associated with intellectual disability, highlight RNA-editing dysregulation in ASD and reveal new mechanisms underlying this disorder....
Transcriptomic analyses of postmortem brains have begun to elucidate molecular abnormalities in autism spectrum disorder (ASD). ...Ou …
Altered proliferation and networks in neural cells derived from idiopathic autistic individuals.
Marchetto MC, et al. Mol Psychiatry 2017. PMID 27378147 Free PMC article.
ASD-derived NPCs display increased cell proliferation because of dysregulation of a β-catenin/BRN2 transcriptional cascade. ASD-derived neurons display abnormal neurogenesis and reduced synaptogenesis leading to functional defects in neuronal networks. Interestingly, defects in neuronal networks could be rescued by insulin growth factor 1 (IGF-1), a drug that is currently in clinical trials for ASD. ...
ASD-derived NPCs display increased cell proliferation because of dysregulation of a β-catenin/BRN2 transcriptional casc …
Autistic disorder and phospholipids: A review.
Brown CM and Austin DW. Prostaglandins Leukot Essent Fatty Acids 2011 - Review. PMID 20970971
Dysregulated phospholipid metabolism has been proposed as an underlying biological component of neurodevelopmental disorders such as autistic disorder (AD) and attention-deficit/hyperactivity disorder (ADHD). This review provides an overview of fatty acid and phospholipid metabolism and evidence for phospholipid dysregulation with reference to the membrane hypothesis of schizophrenia. ...
Dysregulated phospholipid metabolism has been proposed as an underlying biological component of neurodevelopmental disorders s
Toward a conceptual framework for early brain and behavior development in autism.
Piven J, et al. Mol Psychiatry 2017 - Review. PMID 28937691 Free PMC article.
Studies of infant siblings of older autistic probands, who are at elevated risk for autism, have demonstrated that the defining features of autism are not present in the first year of life but emerge late in the first and into the second year. ...This process is linked to brain volume overgrowth and disruption of the refinement of neural circuit connections and is associated with the emergence of autistic social deficits in the second year of life. ...
Studies of infant siblings of older autistic probands, who are at elevated risk for autism, have demonstrated that the defi
Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder.
Deshpande A, et al. Cell Rep 2017. Among authors: Dao DQ. PMID 29212016 Free PMC article.
A deletion or duplication in the 16p11.2 region is associated with neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. ...Interestingly, both 16pdel and 16pdup neurons displayed reduced synaptic density, suggesting that distinct mechanisms may underlie brain size and neuronal connectivity at this locus....
A deletion or duplication in the 16p11.2 region is associated with neurodevelopmental disorders, including autism spect …
Overexpression of LINE-1 Retrotransposons in Autism Brain
Shpyleva S, et al. Mol Neurobiol 2018. PMID 28220356
Long interspersed nuclear elements-1 (LINE-1 or L1) are mobile DNA sequences that are capable of duplication and insertion (retrotransposition) within the genome. ...Based on this evidence and our reports of oxidative stress and epigenetic dysregulation in autism cerebellum, we sought to determine whether L1 expression was increased in autism brain. ...
Long interspersed nuclear elements-1 (LINE-1 or L1) are mobile DNA sequences that are capable of duplication and insertion (re …
Progress and roadblocks in the search for brain-based biomarkers of autism and attention-deficit/hyperactivity disorder.
Uddin LQ, et al. Transl Psychiatry 2017 - Review. Among authors: Dajani DR. PMID 28892073 Free PMC article.
The objective of this review is to provide an overview of current progress in the use of neuroimaging to identify brain-based biomarkers for autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), two prevalent neurodevelopmental disorders. ...The most successful machine learning methods that have been developed and applied to date are discussed. Overall, there is increasing evidence that specific features (for example, functional connectivity, gray matter volume) of brain regions comprising the salience and default mode networks can be used to discriminate ASD from typical development. ...
The objective of this review is to provide an overview of current progress in the use of neuroimaging to identify brain-based biomarkers for …
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