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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 2
1978 1
1979 2
1980 6
1981 4
1982 5
1983 6
1984 6
1985 4
1986 2
1987 7
1988 4
1989 3
1990 3
1991 5
1992 5
1993 4
1994 2
1995 4
1996 3
1997 5
1998 4
1999 2
2000 2
2001 4
2002 2
2003 3
2004 8
2005 11
2006 33
2007 88
2008 116
2009 167
2010 233
2011 367
2012 516
2013 603
2014 706
2015 811
2016 959
2017 1033
2018 1165
2019 563
2020 10
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6,529 results
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Page 1
Autophagy inhibitors.
Pasquier B. Cell Mol Life Sci 2016 - Review. PMID 26658914
The main function of autophagy is the maintenance of cell survival when modifications occur in the cellular environment. During the past decade, extensive studies have greatly improved our knowledge and autophagy has exploded as a research field. This process is now widely implicated in pathophysiological processes such as cancer, metabolic, and neurodegenerative disorders, making it an attractive target for drug discovery. ...
The main function of autophagy is the maintenance of cell survival when modifications occur in the cellular environment. During the p …
ER Stress and Autophagy.
Lee WS, et al. Curr Mol Med 2015 - Review. PMID 26391548
It is now apparent that ER stress is also a potent trigger for autophagy, a self-degradative process that has an adaptive function. This review surveys the intersection of ER stress and autophagy and highlights the potential therapeutic implications thereof....
It is now apparent that ER stress is also a potent trigger for autophagy, a self-degradative process that has an adaptive function. T …
Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment.
Yoshida GJ. J Hematol Oncol 2017 - Review. PMID 28279189 Free PMC article.
Furthermore, several studies of drug re-positioning suggest that "conventional" agents used to treat diseases other than cancer can have antitumor therapeutic effects by activating/suppressing autophagy. ...Antimalarial agents such as artemisinin and disease-modifying antirheumatic drug (DMARD) are the typical examples of drug re-positioning which affect the autophagy regulation for the therapeutic use. ...
Furthermore, several studies of drug re-positioning suggest that "conventional" agents used to treat diseases other than cancer can h …
Targeting Autophagy to Overcome Human Diseases.
Condello M, et al. Int J Mol Sci 2019 - Review. PMID 30744021 Free PMC article.
Dysregulation of autophagy can induce various disease manifestations, such as inflammation, aging, metabolic diseases, neurodegenerative disorders and cancer. ...There are still questions that must be answered concerning the functions of the autophagy-related proteins. In this review, we describe the principal cellular and molecular autophagic functions, selective types of autophagy and the main in vitro methods to detect the role of autophagy in the cellular physiology. ...
Dysregulation of autophagy can induce various disease manifestations, such as inflammation, aging, metabolic diseases, neurodegenerat …
Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases.
Ren J and Zhang Y. Trends Pharmacol Sci 2018 - Review. PMID 30458935 Free PMC article.
Autophagy degrades and removes long-lived or damaged cellular organelles and proteins, the functions of which decline with advanced aging. ...Here we dissect the mechanism of action for autophagy failure in aging and discuss the potential rationale of targeting autophagy using pharmacological agents as new avenues in the combating of biological and cardiovascular aging....
Autophagy degrades and removes long-lived or damaged cellular organelles and proteins, the functions of which decline with advanced a
Mood-stabilizing effects of rapamycin and its analog temsirolimus: relevance to autophagy.
Kara NZ, et al. Behav Pharmacol 2018. PMID 28777104
Our previous data show that pharmacological enhancement of autophagy results in antidepressant-like effects in mice. The current study was designed to further examine the effects of autophagy enhancement on mood by testing the effects of subchronic treatment with the mammalian target of rapamycin (mTOR) inhibitors and autophagy enhancers rapamycin and temsirolimus in a model for mania and in a model for antidepressant action, respectively. ...Taken together with our previous findings, these data support the notion that enhancing autophagy may have mood-stabilizing effects....
Our previous data show that pharmacological enhancement of autophagy results in antidepressant-like effects in mice. The curre …
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi L, et al. Nat Rev Drug Discov 2017 - Review. PMID 28529316 Free PMC article.
Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have been linked to clinically relevant conditions as diverse as cancer, neurodegeneration and cardiac disorders. ...In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic....
Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alt
Targeting autophagy as a strategy for drug discovery and therapeutic modulation.
Gao L, et al. Future Med Chem 2017 - Review. PMID 28176543
The molecular components of autophagy are currently being explored as new pharmacologic targets for drug development and therapeutic intervention of various diseases. ...Here, we review the role of autophagy and its alterations in the pathogenesis of diverse diseases, and drug discovery strategies for modulating autophagy for therapeutic benefits as well as possible safety concerns and caveats associated with such approaches....
The molecular components of autophagy are currently being explored as new pharmacologic targets for drug development and thera …
The Effects of Propofol on Autophagy.
Guo XN and Ma X. DNA Cell Biol 2020 - Review. PMID 31880481
Extensive studies have been performed to better understand the regulation of autophagy by propofol, the majority of which have demonstrated that the effects of propofol on autophagy are beneficial to organs and tissues. In this review, we retrospectively analyzed studies to assess the effects of propofol on autophagy in different diseases and evaluated the underlying mechanisms....
Extensive studies have been performed to better understand the regulation of autophagy by propofol, the majority of which have demons …
Autophagy in Cardiovascular Aging.
Abdellatif M, et al. Circ Res 2018 - Review. PMID 30355077
In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life- and health-span extension. ...We conclude that autophagy is a fundamental process to ensure cardiac and vascular health during aging and outline its putative therapeutic importance....
In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life- and health-span extension. . …
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