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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1990 5
1991 6
1992 7
1993 5
1994 2
1995 7
1996 6
1997 8
1998 8
1999 10
2000 16
2001 21
2002 25
2003 29
2004 62
2005 74
2006 182
2007 273
2008 391
2009 398
2010 415
2011 414
2012 538
2013 744
2014 820
2015 807
2016 703
2017 846
2018 862
2019 369
2020 4
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7,096 results
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Page 1
Autophagy: The spotlight for cellular stress responses.
Ravanan P, et al. Life Sci 2017 - Review. PMID 28866100
Similarly, inhibiting autophagy would contribute in the treatment of cancer. However, understanding the biology of autophagy regulation requires pharmacologically active compounds which modulate the autophagy process. ...Both induction and inhibition of autophagy have been proven to be beneficial in the treatment of cancer. This dual role of autophagy in cancers is now getting uncovered by the advancement in the research findings and development of effective autophagy modulators....
Similarly, inhibiting autophagy would contribute in the treatment of cancer. However, understanding the biology of autophagy r …
Autophagy-monitoring and autophagy-deficient mice.
Kuma A, et al. Autophagy 2017 - Review. PMID 28820286 Free PMC article.
Specific identification of autophagy-related structures is important to evaluate autophagic activity, and specific ablation of autophagy-related genes is a critical means to determine the requirements of autophagy. Here, we review currently available mouse models, particularly focusing on autophagy (and mitophagy) indicator models and systemic autophagy-related gene-knockout mouse models....
Specific identification of autophagy-related structures is important to evaluate autophagic activity, and specific ablation of aut
Historical landmarks of autophagy research.
Ohsumi Y. Cell Res 2014 - Review. PMID 24366340 Free PMC article.
Next, a genetic effort to address the poorly understood problem of autophagy led to the discovery of many autophagy-defective mutants. Subsequent identification of autophagy-related genes in yeast revealed unique sets of molecules involved in membrane dynamics during autophagy. ...
Next, a genetic effort to address the poorly understood problem of autophagy led to the discovery of many autophagy-defective …
Mechanism and medical implications of mammalian autophagy.
Dikic I and Elazar Z. Nat Rev Mol Cell Biol 2018 - Review. PMID 29618831
Thus, autophagy has primarily cytoprotective functions and needs to be tightly regulated to respond correctly to the different stimuli that cells experience, thereby conferring adaptation to the ever-changing environment. It is now apparent that autophagy is deregulated in the context of various human pathologies, including cancer and neurodegeneration, and its modulation has considerable potential as a therapeutic approach....
Thus, autophagy has primarily cytoprotective functions and needs to be tightly regulated to respond correctly to the different stimul …
Autophagy in health and disease: A comprehensive review.
Saha S, et al. Biomed Pharmacother 2018 - Review. PMID 29800913
Similarly, muscular and heart disorders have been shown to be positively and negatively regulated by autophagy, respectively. In the present review, we, therefore, present a comprehensive review on the role of autophagy in various diseases and their corresponding outcomes....
Similarly, muscular and heart disorders have been shown to be positively and negatively regulated by autophagy, respectively. In the …
Autophagy: cellular and molecular mechanisms.
Glick D, et al. J Pathol 2010 - Review. PMID 20225336 Free PMC article.
Thus, autophagy is generally thought of as a survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Autophagy can be either non-selective or selective in the removal of specific organelles, ribosomes and protein aggregates, although the mechanisms regulating aspects of selective autophagy are not fully worked out. ...
Thus, autophagy is generally thought of as a survival mechanism, although its deregulation has been linked to non-apoptotic cell deat …
Life, death and autophagy.
Doherty J and Baehrecke EH. Nat Cell Biol 2018 - Review. PMID 30224761
Several lines of evidence indicate that autophagy is a multifaceted regulator of cell death, but controversy exists over whether autophagy alone can drive cell death under physiologically relevant circumstances. Here, we review the role of autophagy in cell death and examine how autophagy interfaces with other forms of cell death including apoptosis and necrosis....
Several lines of evidence indicate that autophagy is a multifaceted regulator of cell death, but controversy exists over whether a
Recent insights into the function of autophagy in cancer.
Amaravadi R, et al. Genes Dev 2016 - Review. PMID 27664235 Free PMC article.
Autophagy also plays a major homeostatic role in controlling protein and organelle quality and quantity. Dysfunctional autophagy contributes to many diseases. In cancer, autophagy can be neutral, tumor-suppressive, or tumor-promoting in different contexts. Large-scale genomic analysis of human cancers indicates that the loss or mutation of core autophagy genes is uncommon, whereas oncogenic events that activate autophagy and lysosomal biogenesis have been identified. ...
Autophagy also plays a major homeostatic role in controlling protein and organelle quality and quantity. Dysfunctional autophagy
The coming of age of chaperone-mediated autophagy.
Kaushik S and Cuervo AM. Nat Rev Mol Cell Biol 2018 - Review. PMID 29626215 Free PMC article.
Chaperone-mediated autophagy (CMA) was the first studied process that indicated that degradation of intracellular components by the lysosome can be selective - a concept that is now well accepted for other forms of autophagy. ...
Chaperone-mediated autophagy (CMA) was the first studied process that indicated that degradation of intracellular components by the l …
Autophagy and Mitophagy in Cardiovascular Disease.
Bravo-San Pedro JM, et al. Circ Res 2017 - Review. PMID 28546358
Autophagy contributes to the maintenance of intracellular homeostasis in most cells of cardiovascular origin, including cardiomyocytes, endothelial cells, and arterial smooth muscle cells. ...In this review, we discuss the intimate connection between autophagy, mitophagy, and cardiovascular disorders....
Autophagy contributes to the maintenance of intracellular homeostasis in most cells of cardiovascular origin, including cardiomyocyte
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