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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 2
1969 2
1971 4
1972 4
1973 7
1974 4
1975 4
1976 1
1977 3
1978 1
1979 5
1980 8
1981 7
1982 2
1983 7
1984 4
1985 5
1986 13
1987 11
1988 10
1989 12
1990 15
1991 4
1992 10
1993 11
1994 19
1995 14
1996 11
1997 13
1998 7
1999 6
2000 11
2001 11
2002 6
2003 6
2004 4
2005 14
2006 13
2007 13
2008 14
2009 15
2010 15
2011 15
2012 19
2013 15
2014 24
2015 18
2016 11
2017 22
2018 22
2019 5
2020 0
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463 results
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Page 1
Primary Biliary Cholangitis: Its Pathological Characteristics and Immunopathological Mechanisms
Tsuneyama K, et al. J Med Invest 2017 - Review. PMID 28373632 Free article.
Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is an organ-specific autoimmune disease that predominantly affects middle-aged women and is characterized by the chronic progressive destruction of small intrahepatic bile ducts with portal inflammation and, ultimately, fibrosis. ...Several mechanisms have been proposed for immune-mediated bile duct damage in PBC, including the roles of T cells, B cells, other cell phenotypes, and AMA. ...
Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is an organ-specific autoimmune disease that predominantly a …
Bile Acids in Cholestasis and its Treatment.
Arab JP, et al. Ann Hepatol 2017 - Review. PMID 29080340 Free article.
Bile acids (BA) are key molecules in generating bile flow, which is an essential function of the liver. In the last decades there have been great advances in the understanding of the role of a number of specific transport proteins present at the sinusoidal and canalicular membrane domains of hepatocytes and cholangiocytes in generating and maintaining bile flow. ...In this context, therapeutic approaches including new hydrophilic BA such as the conjugation-resistant nor- ursodeoxycholic acid, nuclear receptors (FXR, PPAR-alpha) agonists, FGF19 analogues, inhibitors of the apical sodium-dependent bile acid transporter [ASBT] and modulators of the inflammatory cascade triggered by BAs are being studied as novel treatments of cholestasis. ...
Bile acids (BA) are key molecules in generating bile flow, which is an essential function of the liver. In the last decades th
Primary sclerosing cholangitis leads to dysfunction and loss of MAIT cells
von Seth E, et al. Eur J Immunol 2018. PMID 30252934 Free article.
Mucosal-associated invariant T (MAIT) cells are abundant in human liver and localize around bile ducts. Yet, the role of MAIT cells in PSC remains unclear. ...Using a novel sampling approach of human bile ducts, we found MAIT cells to be specifically enriched within bile ducts. Finally, distinct from the dramatic decline observed in circulation, PSC-patients had retained levels of MAIT cells within bile ducts. ...
Mucosal-associated invariant T (MAIT) cells are abundant in human liver and localize around bile ducts. Yet, the role of MAIT …
Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma
Chung BK, et al. Biochim Biophys Acta Mol Basis Dis 2018 - Review. PMID 28844951 Free article.
Primary sclerosing cholangitis (PSC) is an idiopathic cholangiopathy strongly associated with inflammatory bowel disease (IBD) and characterized by cholestasis, chronic immune infiltration and progressive fibrosis of the intrahepatic and extrahepatic bile ducts. ...PSC-CCA is derived from cholangiocytes and associated progenitor cells - a heterogeneous group of dynamic epithelial cells lining the biliary tree that modulate the composition and volume of bile production by the liver. ...
Primary sclerosing cholangitis (PSC) is an idiopathic cholangiopathy strongly associated with inflammatory bowel disease (IBD) and character …
Autoimmune sclerosing cholangitis: Evidence and open questions
Terziroli Beretta-Piccoli B, et al. J Autoimmun 2018 - Review. PMID 30366655
Juvenile sclerosing cholangitis is a rare chronic hepatobiliary disorder characterized by inflammation of the intra- and/or extrahepatic bile ducts, bile duct dilatation, narrowing and obliteration, and, histologically, by inflammatory bile duct damage leading to periductular fibrosis. ...
Juvenile sclerosing cholangitis is a rare chronic hepatobiliary disorder characterized by inflammation of the intra- and/or extrahepatic …
From pathogenesis to novel therapies in the treatment of primary biliary cholangitis
Ronca V, et al. Expert Rev Clin Immunol 2017 - Review. PMID 28994348
Primary biliary cholangitis (PBC) is an immune-mediated liver disease characterized by chronic inflammation of the intrahepatic bile ducts, causing progressive ductopenia, cholestasis and fibrosis, and leading to liver failure. ...
Primary biliary cholangitis (PBC) is an immune-mediated liver disease characterized by chronic inflammation of the intrahepatic bile
Bile acids in regulation of inflammation and immunity: friend or foe?
Zhu C, et al. Clin Exp Rheumatol 2016 - Review. PMID 27586800 Free article.
Apart from their pivotal role in dietary lipid absorption and cholesterol homeostasis, bile acids (BAs) are increasingly recognised as important signalling molecules in the regulation of systemic endocrine functions. ...
Apart from their pivotal role in dietary lipid absorption and cholesterol homeostasis, bile acids (BAs) are increasingly recognised a …
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