Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 1
1959 1
1965 1
1966 1
1967 4
1968 4
1969 7
1970 6
1971 8
1972 6
1973 4
1974 10
1975 5
1976 9
1977 4
1978 7
1979 3
1980 6
1981 2
1982 7
1983 7
1984 3
1985 4
1986 5
1987 11
1988 14
1989 13
1990 17
1991 18
1992 18
1993 31
1994 27
1995 31
1996 28
1997 52
1998 31
1999 44
2000 36
2001 44
2002 49
2003 38
2004 38
2005 45
2006 48
2007 43
2008 37
2009 40
2010 37
2011 52
2012 48
2013 46
2014 79
2015 53
2016 28
2017 19
2018 24
2019 11
2020 0
Text availability
Article attribute
Article type
Publication date

Search Results

1,183 results
Results by year
Filters applied: . Clear all
Page 1
Animal models of biliary injury and altered bile acid metabolism.
Mariotti V, et al. Biochim Biophys Acta Mol Basis Dis 2018 - Review. PMID 28709963 Free PMC article.
Despite fundamental limitations applying to these models, such as the distinct immune system and the different metabolism regulating liver homeostasis in rodents when compared to humans, multiple approaches, such as surgery (bile duct ligation), chemical-induced (3,5-diethoxycarbonyl-1,4-dihydrocollidine, DDC, α-naphthylisothiocyanate, ANIT), viral infections (Rhesus rotavirustype A, RRV-A), and genetic manipulation (Mdr2, Cftr, Pkd1, Pkd2, Prkcsh, Sec63, Pkhd1) have been developed. Overall, they have led to a range of liver phenotypes recapitulating the main features of biliary injury and altered bile acid metabolisms, such as ductular reaction, peribiliary inflammation and fibrosis, obstructive cholestasis and biliary dysgenesis. ...
Despite fundamental limitations applying to these models, such as the distinct immune system and the different metabolism regulating …
Bile acid receptors in the biliary tree: TGR5 in physiology and disease.
Deutschmann K, et al. Biochim Biophys Acta Mol Basis Dis 2018 - Review. PMID 28844960 Free article.
Bile salts represent signalling molecules with a variety of endocrine functions. Bile salt effects are mediated by different receptor molecules, comprising ligand-activated nuclear transcription factors as well as G protein-coupled membrane-bound receptors. ...Furthermore, in absence of TGR5 cholangiocyte proliferation in response to cholestasis is attenuated and intrahepatic and extrahepatic bile ducts show increased cell damage, underscoring the role of the receptor for biliary physiology. ...
Bile salts represent signalling molecules with a variety of endocrine functions. Bile salt effects are mediated by different r
Observations on the ex situ perfusion of livers for transplantation
Watson CJE, et al. Am J Transplant 2018 - Clinical Trial. PMID 29419931 Free PMC article.
In the 11 research livers where it could be studied, bile pH > 7.5 discriminated between the 6 livers exhibiting >50% circumferential stromal necrosis of septal bile ducts and 4 without necrosis; one liver with 25-50% necrosis had a maximum pH 7.46. Liver viability during normothermic perfusion can be assessed using a combination of transaminase release, glucose metabolism, lactate clearance, and maintenance of acid-base balance. ...
In the 11 research livers where it could be studied, bile pH > 7.5 discriminated between the 6 livers exhibiting >50% circumfer …
Cholesterol and bile acid metabolism in cultures of primary rat bile ductular epithelial cells.
Hylemon PB, et al. Hepatology 1990. PMID 2365295
The role of hepatocytes in bile acid and cholesterol metabolism has been extensively studied. By contrast, nothing is known about the role of bile ductular epithelial cells in cholesterol and bile acid metabolism. The purpose of the current studies was to establish whether bile ductular epithelial cells synthesize cholesterol, bile acids or both and to determine whether these cells are capable of metabolizing (hydroxylating, conjugating) bile acids. ...
The role of hepatocytes in bile acid and cholesterol metabolism has been extensively studied. By contrast, nothing is known ab …
Bile acids stimulate cholangiocyte fluid secretion by activation of transmembrane member 16A Cl(-) channels.
Li Q, et al. Hepatology 2018. PMID 29360145 Free PMC article.
CONCLUSION: Bile acids stimulate Cl(-) secretion in mouse and human biliary cells through activation of membrane TMEM16A channels in a process regulated by extracellular ATP and [Ca(2+) ](i) . These studies suggest that TMEM16A channels may be targets to increase bile flow during cholestasis. (Hepatology 2018;68:187-199)....
CONCLUSION: Bile acids stimulate Cl(-) secretion in mouse and human biliary cells through activation of membrane TMEM16A channels in …
BASIC--a bile acid-sensitive ion channel highly expressed in bile ducts.
Wiemuth D, et al. FASEB J 2012. PMID 22735174
Here, we show that the BLINaC protein localizes to cholangiocytes, epithelial cells that line bile ducts. Moreover, we provide evidence that rBLINaC and INaC are robustly activated by bile acids, in particular chenodeoxycholic acid and hyodeoxycholic acid (EC50=2.1±0.05 mM). Thus, BLINaC appears to be an epithelial cation channel of bile ducts sensitive to physiological concentrations of bile acids. ...
Here, we show that the BLINaC protein localizes to cholangiocytes, epithelial cells that line bile ducts. Moreover, we provide …
Pancreatic enzymes in the epithelium of intrahepatic large bile ducts and in hepatic bile in patients with extrahepatic bile duct obstruction.
Terada T, et al. J Clin Pathol 1994. PMID 7962606 Free PMC article.
Immunohistochemically, the immunoreactivity of the three enzymes was present in epithelia and in the lumina of intrahepatic large bile ducts, septal bile ducts, and peribiliary glands in all cases. CONCLUSIONS: These results strongly suggest that biliary epithelia of larger intrahepatic ducts produce pancreatic alpha-amylase, lipase, and trypsin, and that these enzymes are secreted into the lumina of intrahepatic bile ducts....
Immunohistochemically, the immunoreactivity of the three enzymes was present in epithelia and in the lumina of intrahepatic large bile
A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule
Meyer K, et al. Cell Syst 2017. PMID 28330614 Free article.
Bile, the central metabolic product of the liver, is transported by the bile canaliculi network. The impairment of bile flow in cholestatic liver diseases has urged a demand for insights into its regulation. ...The model integrates the structure of the bile canalicular network in the mouse liver lobule, as determined by high-resolution confocal and serial block-face scanning electron microscopy, with measurements of bile transport by intravital microscopy. ...
Bile, the central metabolic product of the liver, is transported by the bile canaliculi network. The impairment of bile
Pipe-3D: A Pipeline Based on Immunofluorescence, 3D Confocal Imaging, Reconstructions, and Morphometry for Biliary Network Analysis in Cholestasis
Damle-Vartak A, et al. Methods Mol Biol 2019. PMID 31016646
The ductular reaction is characterized by enhanced proliferation of cholangiocytes, which form the epithelial lining of bile ducts. ...The response of interlobular ducts in cholestasis was shown to be in sharp contrast to that of large bile ducts, de novo duct formation during embryogenesis. ...
The ductular reaction is characterized by enhanced proliferation of cholangiocytes, which form the epithelial lining of bile ducts
1,183 results
Jump to page
Feedback