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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1952 4
1953 10
1954 18
1955 18
1956 15
1957 17
1958 23
1959 10
1960 3
1961 13
1962 13
1963 1
1964 4
1965 35
1966 50
1967 55
1968 77
1969 80
1970 55
1971 71
1972 80
1973 88
1974 110
1975 89
1976 74
1977 63
1978 64
1979 58
1980 67
1981 62
1982 57
1983 80
1984 84
1985 76
1986 90
1987 76
1988 110
1989 122
1990 112
1991 109
1992 103
1993 138
1994 151
1995 120
1996 119
1997 167
1998 139
1999 136
2000 144
2001 157
2002 154
2003 171
2004 149
2005 161
2006 171
2007 155
2008 157
2009 153
2010 171
2011 182
2012 177
2013 162
2014 217
2015 184
2016 147
2017 120
2018 122
2019 46
2020 1
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6,091 results
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Page 1
Cholangiocyte pathobiology
Banales JM, et al. Nat Rev Gastroenterol Hepatol 2019 - Review. PMID 30850822 Free PMC article.
Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are highly specialized cells residing in a complex anatomic niche where they participate in bile production and homeostasis. ...
Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are highly specialized cells residin …
Role of β-catenin in development of bile ducts.
Cordi S, et al. Differentiation 2016. PMID 26856660 Free PMC article.
However, its role in development of bile ducts has not yet been addressed. Here we used stage-specific in vivo gain- and loss-of-function approaches, as well as lineage tracing experiments in the mouse, to first demonstrate that β-catenin is dispensable for differentiation of liver precursor cells (hepatoblasts) to cholangiocyte precursors. Second, when β-catenin was depleted in the latter, maturation of cholangiocytes, bile duct morphogenesis and differentiation of periportal hepatocytes from cholangiocyte precursors was normal. ...
However, its role in development of bile ducts has not yet been addressed. Here we used stage-specific in vivo gain- and loss- …
Physiology of bile secretion.
Esteller A. World J Gastroenterol 2008 - Review. PMID 18837079 Free PMC article.
This review summarizes recent data on the molecular determinants of this primary bile formation. The major function of the biliary tree is modification of canalicular bile by secretory and reabsorptive processes in bile-duct epithelial cells (cholangiocytes) as bile passes through bile ducts. ...A short section dedicated to these regulatory mechanisms of bile secretion has been included. The aim of this revision was to set the bases for other reviews in this series that will be devoted to specific issues related with biliary physiology and pathology....
This review summarizes recent data on the molecular determinants of this primary bile formation. The major function of the biliary tr …
Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery.
Koch M, et al. Surgery 2011. PMID 21316725
Using this criterion severity of bile leakage was classified according to its impact on patients' clinical management. Grade A bile leakage causes no change in patients' clinical management. A Grade B bile leakage requires active therapeutic intervention but is manageable without relaparotomy, whereas in Grade C, bile leakage relaparotomy is required. ...
Using this criterion severity of bile leakage was classified according to its impact on patients' clinical management. Grade A bil
A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule
Meyer K, et al. Cell Syst 2017. PMID 28330614 Free article.
Bile, the central metabolic product of the liver, is transported by the bile canaliculi network. The impairment of bile flow in cholestatic liver diseases has urged a demand for insights into its regulation. ...The model integrates the structure of the bile canalicular network in the mouse liver lobule, as determined by high-resolution confocal and serial block-face scanning electron microscopy, with measurements of bile transport by intravital microscopy. ...
Bile, the central metabolic product of the liver, is transported by the bile canaliculi network. The impairment of bile
Regulators of Cholangiocyte Proliferation
Hall C, et al. Gene Expr 2017 - Review. PMID 27412505 Free PMC article.
This article summarizes landmark studies in the field of cholangiocyte physiology and aims to provide an updated review of biliary pathogenesis. ...Cholangiocyte physiology is a complex system based on heterogeneity within the biliary tree and a number of signaling pathways that serve to regulate bile composition. ...
This article summarizes landmark studies in the field of cholangiocyte physiology and aims to provide an updated review of biliary pa …
Biliary system architecture: experimental models and visualization techniques
Sarnova L and Gregor M. Physiol Res 2017 - Review. PMID 28248543 Free article.
The complex architecture of the liver biliary network represents a structural prerequisite for the formation and secretion of bile as well as excretion of toxic substances through bile ducts. ...Cholestatic liver disease is a condition that results from an impairment of bile formation or bile flow to the gallbladder and duodenum. ...
The complex architecture of the liver biliary network represents a structural prerequisite for the formation and secretion of bile as …
Development of the liver and bile ducts.
Suchy F and Narkewicz MR. J Pediatr Gastroenterol Nutr 2002 - Review. PMID 12151813
The immunobiology of cholangiocytes
Chen XM, et al. Immunol Cell Biol 2008 - Review. PMID 18504452 Free PMC article.
Cholangiocytes, the epithelial cells lining bile ducts, provide the first line of defense against lumenal microbes in the biliary system. ...
Cholangiocytes, the epithelial cells lining bile ducts, provide the first line of defense against lumenal microbes in the bili …
The etiology of "white bile" in the biliary tree.
Hashmonai M, et al. J Surg Res 1984. PMID 6513544
When "black bile" was present, the direction of flow was from the extrahepatic ducts into the gallbladder. Whenever "white bile" developed, a reverse flow from the extrahepatic ducts into the liver was observed. ...In the absence of the gallbladder water absorption activity, the colorless secretion of the bile ducts seems to "back wash" into the liver and replace the bile present in the ducts at the time of occlusion....
When "black bile" was present, the direction of flow was from the extrahepatic ducts into the gallbladder. Whenever "white …
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