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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1990 1
1991 1
1994 14
1995 47
1996 33
1997 65
1998 72
1999 111
2000 104
2001 206
2002 211
2003 248
2004 367
2005 446
2006 562
2007 637
2008 678
2009 714
2010 792
2011 803
2012 1031
2013 1110
2014 1213
2015 1206
2016 1213
2017 1192
2018 1219
2019 668
2020 8
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13,160 results
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Page 1
Targeting microbial biofilms: current and prospective therapeutic strategies.
Koo H, et al. Nat Rev Microbiol 2017 - Review. PMID 28944770 Free PMC article.
The multifactorial nature of biofilm development and drug tolerance imposes great challenges for the use of conventional antimicrobials and indicates the need for multi-targeted or combinatorial therapies. In this Review, we focus on current therapeutic strategies and those under development that target vital structural and functional traits of microbial biofilms and drug tolerance mechanisms, including the extracellular matrix and dormant cells. ...
The multifactorial nature of biofilm development and drug tolerance imposes great challenges for the use of conventional antimicrobia …
Biofilms: Survival and defense strategy for pathogens.
Kumar A, et al. Int J Med Microbiol 2017 - Review. PMID 28950999
Biofilm, considered as a generic mechanism for survival used by pathogenic as well as non-pathogenic microorganisms, involves surface attachment and growth of heterogeneous cells encapsulated within a matrix. ...In the backdrop of recent reports suggesting that biofilms can harbour multiple species of organisms, we need to relook and devise newer strategies against biofilms. ...
Biofilm, considered as a generic mechanism for survival used by pathogenic as well as non-pathogenic microorganisms, involves surface attach …
Staphylococcus aureus biofilm: a complex developmental organism.
Moormeier DE and Bayles KW. Mol Microbiol 2017 - Review. PMID 28142193 Free PMC article.
The purpose of this review is to summarize our current understanding of S. aureus biofilm development, focusing on the description of a newly-defined, five-stage model of biofilm development and the mechanisms required for each stage. ...Importantly, it is proposed that this new model of biofilm development involves the genetically programmed generation of metabolically distinct subpopulations of cells, resulting in an overall population that is better able to adapt to rapidly changing environmental conditions....
The purpose of this review is to summarize our current understanding of S. aureus biofilm development, focusing on the description of …
Biofilm Development.
Tolker-Nielsen T. Microbiol Spectr 2015 - Review. PMID 26104692
It appears that biofilm formation can occur through multiple pathways and that the spatial structure of the biofilms is species dependent as well as dependent on environmental conditions. ...
It appears that biofilm formation can occur through multiple pathways and that the spatial structure of the biofilms is species depen …
Biofilm formation as microbial development.
O'Toole G, et al. Annu Rev Microbiol 2000 - Review. PMID 11018124
Recent genetic and molecular approaches used to study bacterial and fungal biofilms have identified genes and regulatory circuits important for initial cell-surface interactions, biofilm maturation, and the return of biofilm microorganisms to a planktonic mode of growth. ...The results reviewed in this article indicate that the formation of biofilms serves as a new model system for the study of microbial development....
Recent genetic and molecular approaches used to study bacterial and fungal biofilms have identified genes and regulatory circuits imp …
Biofilm dispersion in Pseudomonas aeruginosa
Kim SK and Lee JH. J Microbiol 2016 - Review. PMID 26832663
In recent decades, many researchers have written numerous articles about microbial biofilms. Biofilm is a complex community of microorganisms and an example of bacterial group behavior. Biofilm is usually considered a sessile mode of life derived from the attached growth of microbes to surfaces, and most biofilms are embedded in self-produced extracellular matrix composed of extracellular polymeric substances (EPSs), such as polysaccharides, extracellular DNAs (eDNA), and proteins. ...
In recent decades, many researchers have written numerous articles about microbial biofilms. Biofilm is a complex community of microo …
Peri-implantitis and its prevention
Berglundh T, et al. Clin Oral Implants Res 2019. PMID 30636066
Physico-chemistry from initial bacterial adhesion to surface-programmed biofilm growth.
Carniello V, et al. Adv Colloid Interface Sci 2018 - Review. PMID 30376953 Free article.
Membrane-located sensor molecules subsequently react to control emergent phenotypic and genotypic properties in biofilms, most notably adhesion-associated ones like EPS production. ...This conclusion is pivotal for the development of new strategies to control biofilm formation on substratum surfaces, that have hitherto been largely confined to the initial bacterial adhesion phenomena....
Membrane-located sensor molecules subsequently react to control emergent phenotypic and genotypic properties in biofilms, most notabl …
Biofilm dispersion and quorum sensing
Solano C, et al. Curr Opin Microbiol 2014 - Review. PMID 24657330
Biofilm development and quorum sensing (QS) are closely interconnected processes. Biofilm formation is a cooperative group behaviour that involves bacterial populations living embedded in a self-produced extracellular matrix. ...
Biofilm development and quorum sensing (QS) are closely interconnected processes. Biofilm formation is a cooperative group behaviour …
Confined Flow: Consequences and Implications for Bacteria and Biofilms.
Conrad JC and Poling-Skutvik R. Annu Rev Chem Biomol Eng 2018 - Review. PMID 29561646
Moreover, these flows occur on time and length scales comparable to those associated with motility of bacteria and with the formation and growth of biofilms, which are surface-associated communities that house the vast majority of bacteria to protect them from host and environmental stresses. ...This understanding will inform the development and deployment of technologies for drug delivery, water treatment, and antifouling coatings and guide the structuring of bacterial consortia for production of chemicals and pharmaceuticals....
Moreover, these flows occur on time and length scales comparable to those associated with motility of bacteria and with the formation and …
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