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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 14
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 409
1829 568
1830 510
1831 579
1832 284
1833 221
1834 209
1835 222
1836 220
1837 281
1838 265
1839 289
1840 395
1841 829
1842 971
1843 813
1844 609
1845 681
1846 746
1847 774
1848 799
1849 744
1850 756
1851 773
1852 765
1853 901
1854 827
1855 1090
1856 1283
1857 1275
1858 1339
1859 1319
1860 1210
1861 945
1862 904
1863 823
1864 937
1865 936
1866 1238
1867 1433
1868 1510
1869 1578
1870 1532
1871 1915
1872 1976
1873 2037
1874 2164
1875 2147
1876 1935
1877 2006
1878 2242
1879 2176
1880 2449
1881 2736
1882 2269
1883 2732
1884 2785
1885 3062
1886 3088
1887 3726
1888 3713
1889 4022
1890 3901
1891 3445
1892 3942
1893 4215
1894 3657
1895 4018
1896 4302
1897 4548
1898 4509
1899 4031
1900 3660
1901 3764
1902 3828
1903 3777
1904 3936
1905 3962
1906 3872
1907 4324
1908 4513
1909 4766
1910 4885
1911 5098
1912 5016
1913 5248
1914 5243
1915 4701
1916 4569
1917 4274
1918 4211
1919 4478
1920 5037
1921 4703
1922 4192
1923 4519
1924 4945
1925 5058
1926 5397
1927 5945
1928 5537
1929 5798
1930 5694
1931 5572
1932 5629
1933 5695
1934 5577
1935 5736
1936 5448
1937 5378
1938 5829
1939 5614
1940 5024
1941 4865
1942 4800
1943 4543
1944 4764
1945 20490
1946 53907
1947 65016
1948 70701
1949 62795
1950 85769
1951 103729
1952 108064
1953 108904
1954 105914
1955 108545
1956 107007
1957 111522
1958 109458
1959 109963
1960 112139
1961 120104
1962 125637
1963 141521
1964 162087
1965 176644
1966 179745
1967 191501
1968 207847
1969 215033
1970 218960
1971 222894
1972 227483
1973 230610
1974 234498
1975 248183
1976 250199
1977 249549
1978 257783
1979 265021
1980 266717
1981 271079
1982 282623
1983 294191
1984 302118
1985 318258
1986 330680
1987 346597
1988 362869
1989 376760
1990 381644
1991 379346
1992 380824
1993 388577
1994 400148
1995 409372
1996 419344
1997 417037
1998 434556
1999 451639
2000 487984
2001 500607
2002 518263
2003 545815
2004 588234
2005 647006
2006 691664
2007 729172
2008 775924
2009 814549
2010 876599
2011 950822
2012 1016690
2013 1067590
2014 1119458
2015 1159456
2016 1191158
2017 1211293
2018 1253501
2019 1308879
2020 1488579
2021 1624499
2022 1616533
2023 687213
2024 4

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33,351,552 results

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Page 1
Design, synthesis, and biological evaluation of novel γ-carboline ketones as anticancer agents.
Chen J, Liu T, Wu R, Lou J, Dong X, He Q, Yang B, Hu Y. Chen J, et al. Eur J Med Chem. 2011 Apr;46(4):1343-7. doi: 10.1016/j.ejmech.2011.01.057. Epub 2011 Feb 20. Eur J Med Chem. 2011. PMID: 21342735
Biological evaluation revealed that almost all of the new compounds displayed moderate to potent cytotoxic activities against the tested cells. Among them, seven of the fourteen new compounds show more potent cytotoxic ac …
Biological evaluation revealed that almost all of the new compounds displayed moderate to potent cytotoxic ac …
Glycosyl disulfides: importance, synthesis and application to chemical and biological systems.
Ribeiro Morais G, Falconer RA. Ribeiro Morais G, et al. Org Biomol Chem. 2021 Jan 6;19(1):82-100. doi: 10.1039/d0ob02079f. Org Biomol Chem. 2021. PMID: 33188377 Review.
This interest has been accompanied and fuelled by the continuous development of new methods to construct the disulfide bond at the anomeric centre. Glycosyl disulfides have also been exploited as versatile intermediates in carbohydrate synthesis, parti …
This interest has been accompanied and fuelled by the continuous development of new methods to construct the disulfide bond at the anomeric …
Synthesis and biological evaluation of thiosemicarbazone derivatives.
Doğan M, Koçyiğit ÜM, Gürdere MB, Ceylan M, Budak Y. Doğan M, et al. Med Oncol. 2022 Jul 21;39(10):157. doi: 10.1007/s12032-022-01784-y. Med Oncol. 2022. PMID: 35861942
According to the results of the cytotoxicity assay, it can be said that the five compounds (3b, c, f, g, and m with IC(50) = 10.59-9.08 mug/mL; Imatinib IC(50) = 11.68 mug/mL) showed more potent cytotoxic activity than Imatinib on C6 cell line. …
According to the results of the cytotoxicity assay, it can be said that the five compounds (3b, c, f, g, and m with IC(50) = 1 …
Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors.
Liu ML, Li WY, Fang HL, Ye YX, Li SY, Song WQ, Xiao ZP, Ouyang H, Zhu HL. Liu ML, et al. ChemMedChem. 2022 Jan 19;17(2):e202100618. doi: 10.1002/cmdc.202100618. Epub 2021 Nov 10. ChemMedChem. 2022. PMID: 34687265
Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell-free urease and urease in intact cell with low cytotoxicity to mammalian cells even at concentration u …
Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against …
Determination of Cytotoxic Activities Against Melanoma Cells Using Flow Cytometry.
Shi G, Heller R. Shi G, et al. Methods Mol Biol. 2021;2265:111-118. doi: 10.1007/978-1-0716-1205-7_8. Methods Mol Biol. 2021. PMID: 33704709
Within the adaptive and innate immune system, effector lymphocytes known as cytotoxic T cells (CTLs) or natural killer (NK) cells play an essential role in host defense against tumor cells and virally infected cells. Here we describe a fl …
Within the adaptive and innate immune system, effector lymphocytes known as cytotoxic T cells (CTLs) or natural killer (NK) …
Synthetic carboline compounds targeting protein: biophysical and biological perspective.
Bhattacharjee P, Sarkar S, Shmatova OI, Nenajdenko VG, Pandya P, Bhadra K. Bhattacharjee P, et al. J Biomol Struct Dyn. 2021 Jul;39(10):3703-3720. doi: 10.1080/07391102.2020.1769732. Epub 2020 Jun 1. J Biomol Struct Dyn. 2021. PMID: 32410501
The compounds were tested for cytotoxic potencies. Comp3, showed maximum cytotoxicity with GI(50) 6.2 M, against HCT-116, followed by comp7, and poor cytotoxicity with comp1. ...In vivo studies regarding therapeutic protective action of Comp3, as a rep …
The compounds were tested for cytotoxic potencies. Comp3, showed maximum cytotoxicity with GI(50) 6.2 M, against HCT-11 …
Selenium cytotoxicity in cancer.
Wallenberg M, Misra S, Björnstedt M. Wallenberg M, et al. Basic Clin Pharmacol Toxicol. 2014 May;114(5):377-86. doi: 10.1111/bcpt.12207. Epub 2014 Mar 3. Basic Clin Pharmacol Toxicol. 2014. PMID: 24529300 Free article. Review.
However, the growth-modulating and cytotoxic mechanisms are diverse and far from clear. Lately, a remarkable tumour selective cytotoxicity of selenium compounds has been shown, indicating the potential of selenium in the treatment of cancer. Of …
However, the growth-modulating and cytotoxic mechanisms are diverse and far from clear. Lately, a remarkable tumour selective cyto …
Redox-active selenium compounds--from toxicity and cell death to cancer treatment.
Misra S, Boylan M, Selvam A, Spallholz JE, Björnstedt M. Misra S, et al. Nutrients. 2015 May 13;7(5):3536-56. doi: 10.3390/nu7053536. Nutrients. 2015. PMID: 25984742 Free PMC article. Review.
One class of selenium compounds is a potent inhibitor of cell growth with remarkable tumor specificity. ...Furthermore, new novel classes of selenium compounds specifically designed to target tumor cells are presented and th …
One class of selenium compounds is a potent inhibitor of cell growth with remarkable tumor specificity. ...Furth …
Synthesis and biological evaluation of novel cabazitaxel analogues.
Ren S, Zhang M, Wang Y, Guo J, Wang J, Li Y, Ding N. Ren S, et al. Bioorg Med Chem. 2021 Jul 1;41:116224. doi: 10.1016/j.bmc.2021.116224. Epub 2021 May 23. Bioorg Med Chem. 2021. PMID: 34058663
Cabazitaxel is one of the most recently FDA-approved taxane anticancer agent. In view of the advantages in preclinical and clinical data of cabazitaxel over former toxoids, the synthesis and biological evaluation of novel cabazitaxel analogues were con …
Cabazitaxel is one of the most recently FDA-approved taxane anticancer agent. In view of the advantages in preclinical and clinical d …
Selenosteroids - promising hybrid compounds with pleiotropic biological activity: synthesis and biological aspects.
Jastrzebska I, Grzes PA, Niemirowicz-Laskowska K, Car H. Jastrzebska I, et al. J Steroid Biochem Mol Biol. 2021 Oct;213:105975. doi: 10.1016/j.jsbmb.2021.105975. Epub 2021 Aug 18. J Steroid Biochem Mol Biol. 2021. PMID: 34418527 Review.
It is established that steroid based agents are an example of compounds obtained from natural patterns and are of great importance due to their application in the prevention and treatment of diseases. ...In this review, we present various methods of synthesis and de …
It is established that steroid based agents are an example of compounds obtained from natural patterns and are of great importance du …
33,351,552 results
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