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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 14
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1488
1843 1121
1844 1251
1845 1278
1846 1404
1847 1368
1848 1203
1849 1208
1850 1126
1851 1228
1852 1312
1853 1558
1854 1306
1855 1587
1856 1588
1857 1488
1858 1542
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1138
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1810
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2180
1878 2455
1879 2399
1880 2646
1881 3149
1882 2742
1883 3127
1884 3049
1885 3337
1886 3291
1887 3965
1888 4002
1889 4194
1890 4024
1891 3607
1892 4064
1893 4369
1894 3801
1895 4129
1896 4412
1897 4688
1898 4631
1899 4169
1900 3785
1901 3886
1902 3967
1903 3910
1904 4059
1905 4067
1906 3872
1907 4324
1908 4459
1909 4687
1910 4799
1911 5006
1912 4906
1913 5104
1914 5135
1915 4640
1916 4543
1917 4281
1918 4568
1919 4618
1920 4960
1921 4628
1922 4123
1923 4432
1924 4850
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5496
1932 5546
1933 5610
1934 5507
1935 5661
1936 5384
1937 5308
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4517
1944 4745
1945 20421
1946 53735
1947 64959
1948 70707
1949 62803
1950 85750
1951 103741
1952 108052
1953 108914
1954 105914
1955 108542
1956 107005
1957 111515
1958 109456
1959 109958
1960 112134
1961 120098
1962 125630
1963 141519
1964 162086
1965 176636
1966 179745
1967 191500
1968 207846
1969 215048
1970 218960
1971 222895
1972 227509
1973 230641
1974 234520
1975 248234
1976 250253
1977 249592
1978 257822
1979 265083
1980 266807
1981 271144
1982 282680
1983 294244
1984 302181
1985 318339
1986 330763
1987 346663
1988 362931
1989 376830
1990 381745
1991 379429
1992 380899
1993 388656
1994 400287
1995 409465
1996 419422
1997 417047
1998 434564
1999 451645
2000 487972
2001 500598
2002 518266
2003 545822
2004 588224
2005 647027
2006 691673
2007 729190
2008 775935
2009 814584
2010 876654
2011 950900
2012 1016781
2013 1067665
2014 1119576
2015 1159743
2016 1191640
2017 1211934
2018 1253989
2019 1310282
2020 1492108
2021 1630644
2022 1627559
2023 1531789
2024 1142665
2025 810

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35,179,921 results

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Page 1
Selenium cytotoxicity in cancer.
Wallenberg M, Misra S, Björnstedt M. Wallenberg M, et al. Basic Clin Pharmacol Toxicol. 2014 May;114(5):377-86. doi: 10.1111/bcpt.12207. Epub 2014 Mar 3. Basic Clin Pharmacol Toxicol. 2014. PMID: 24529300 Free article. Review.
However, the growth-modulating and cytotoxic mechanisms are diverse and far from clear. Lately, a remarkable tumour selective cytotoxicity of selenium compounds has been shown, indicating the potential of selenium in the treatment of cancer. Of particular int …
However, the growth-modulating and cytotoxic mechanisms are diverse and far from clear. Lately, a remarkable tumour selective cytotoxicit …
Synthesis and biological evaluation of thiosemicarbazone derivatives.
Doğan M, Koçyiğit ÜM, Gürdere MB, Ceylan M, Budak Y. Doğan M, et al. Med Oncol. 2022 Jul 21;39(10):157. doi: 10.1007/s12032-022-01784-y. Med Oncol. 2022. PMID: 35861942
Then, ADME parameters, pharmacokinetic properties, drug-like structures, and suitability for medicinal chemistry of these molecules were studied theoretically by using SwissADME and admetSAR programs. ...For this, in vitro anticancer studies of these molecules were done. T …
Then, ADME parameters, pharmacokinetic properties, drug-like structures, and suitability for medicinal chemistry of these molecules w …
Redox-active selenium compounds--from toxicity and cell death to cancer treatment.
Misra S, Boylan M, Selvam A, Spallholz JE, Björnstedt M. Misra S, et al. Nutrients. 2015 May 13;7(5):3536-56. doi: 10.3390/nu7053536. Nutrients. 2015. PMID: 25984742 Free PMC article. Review.
The toxic effects of selenium are, however, strictly concentration and chemical species dependent. One class of selenium compounds is a potent inhibitor of cell growth with remarkable tumor specificity. ...Furthermore, new novel classes of selenium compoun …
The toxic effects of selenium are, however, strictly concentration and chemical species dependent. One class of selenium compounds …
Synthesis and biological evaluation of novel cabazitaxel analogues.
Ren S, Zhang M, Wang Y, Guo J, Wang J, Li Y, Ding N. Ren S, et al. Bioorg Med Chem. 2021 Jul 1;41:116224. doi: 10.1016/j.bmc.2021.116224. Epub 2021 May 23. Bioorg Med Chem. 2021. PMID: 34058663
In view of the advantages in preclinical and clinical data of cabazitaxel over former toxoids, the synthesis and biological evaluation of novel cabazitaxel analogues were conducted. First, a novel semi-synthesis of cabazitaxel was described. This strat …
In view of the advantages in preclinical and clinical data of cabazitaxel over former toxoids, the synthesis and biological …
Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors.
Liu ML, Li WY, Fang HL, Ye YX, Li SY, Song WQ, Xiao ZP, Ouyang H, Zhu HL. Liu ML, et al. ChemMedChem. 2022 Jan 19;17(2):e202100618. doi: 10.1002/cmdc.202100618. Epub 2021 Nov 10. ChemMedChem. 2022. PMID: 34687265
Thirty-eight disulfides containing N-arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biological evaluation revealed that some of the synthetic compounds exhibited strong inhibitory potency against both cell- …
Thirty-eight disulfides containing N-arylacetamide were designed and synthesized in an effort to develop novel urease inhibitors. Biologi …
Glycosyl disulfides: importance, synthesis and application to chemical and biological systems.
Ribeiro Morais G, Falconer RA. Ribeiro Morais G, et al. Org Biomol Chem. 2021 Jan 6;19(1):82-100. doi: 10.1039/d0ob02079f. Org Biomol Chem. 2021. PMID: 33188377 Review.
This interest has been accompanied and fuelled by the continuous development of new methods to construct the disulfide bond at the anomeric centre. Glycosyl disulfides have also been exploited as versatile intermediates in carbohydrate synthesis, particularly …
This interest has been accompanied and fuelled by the continuous development of new methods to construct the disulfide bond at the anomeric …
Synthetic carboline compounds targeting protein: biophysical and biological perspective.
Bhattacharjee P, Sarkar S, Shmatova OI, Nenajdenko VG, Pandya P, Bhadra K. Bhattacharjee P, et al. J Biomol Struct Dyn. 2021 Jul;39(10):3703-3720. doi: 10.1080/07391102.2020.1769732. Epub 2020 Jun 1. J Biomol Struct Dyn. 2021. PMID: 32410501
The compounds were tested for cytotoxic potencies. Comp3, showed maximum cytotoxicity with GI(50) 6.2 M, against HCT-116, followed by comp7, and poor cytotoxicity with comp1. ...In vivo studies regarding therapeutic protective action of Comp3, as a representative ca …
The compounds were tested for cytotoxic potencies. Comp3, showed maximum cytotoxicity with GI(50) 6.2 M, against HCT-116, followed by …
Determination of Cytotoxic Activities Against Melanoma Cells Using Flow Cytometry.
Shi G, Heller R. Shi G, et al. Methods Mol Biol. 2021;2265:111-118. doi: 10.1007/978-1-0716-1205-7_8. Methods Mol Biol. 2021. PMID: 33704709
In this assay, spleen cells, peripheral blood mononuclear cells (PBMCs), or purified NK cell preparations are co-incubated at different ratios with a target tumor cell line. The target cells are pre-labeled with a fluorescent dye to allow their discrimination …
In this assay, spleen cells, peripheral blood mononuclear cells (PBMCs), or purified NK cell preparations are co-incubated at different rati …
Selenosteroids - promising hybrid compounds with pleiotropic biological activity: synthesis and biological aspects.
Jastrzebska I, Grzes PA, Niemirowicz-Laskowska K, Car H. Jastrzebska I, et al. J Steroid Biochem Mol Biol. 2021 Oct;213:105975. doi: 10.1016/j.jsbmb.2021.105975. Epub 2021 Aug 18. J Steroid Biochem Mol Biol. 2021. PMID: 34418527 Review.
Available literature indicates that these kinds of hybrids demonstrate significant anticancer activity, which renders them interesting in terms of medical use. In this review, we present various methods of synthesis and demonstrate that seleno-steroid compounds are promisi …
Available literature indicates that these kinds of hybrids demonstrate significant anticancer activity, which renders them interesting in te …
Synthesis and in vitro anticancer activities of selenium N-heterocyclic carbene compounds.
Huang S, Sheng X, Bian M, Yang Z, Lu Y, Liu W. Huang S, et al. Chem Biol Drug Des. 2021 Sep;98(3):435-444. doi: 10.1111/cbdd.13900. Epub 2021 Jul 7. Chem Biol Drug Des. 2021. PMID: 34051050
Among them, the most active compound 2b was about fourfold more active than the positive control ebselen against A2780 cells. In addition, this compound displayed twofold higher cytotoxicity to A2780 cells than to IOSE80 normal ovarian epithelial cells. ...
Among them, the most active compound 2b was about fourfold more active than the positive control ebselen against A2780 cells. In addition, t …
35,179,921 results
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