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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 14
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1488
1843 1118
1844 1248
1845 1277
1846 1406
1847 1367
1848 1203
1849 1207
1850 1126
1851 1228
1852 1310
1853 1558
1854 1306
1855 1586
1856 1587
1857 1488
1858 1542
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1138
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1809
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2179
1878 2454
1879 2399
1880 2646
1881 3149
1882 2742
1883 3126
1884 3049
1885 3337
1886 3291
1887 3965
1888 4002
1889 4194
1890 4024
1891 3607
1892 4080
1893 4370
1894 3801
1895 4129
1896 4412
1897 4689
1898 4631
1899 4169
1900 3785
1901 3886
1902 3949
1903 3885
1904 4056
1905 4067
1906 3872
1907 4323
1908 4459
1909 4687
1910 4799
1911 5006
1912 4906
1913 5105
1914 5135
1915 4640
1916 4543
1917 4281
1918 4567
1919 4619
1920 4960
1921 4628
1922 4123
1923 4432
1924 4851
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5496
1932 5548
1933 5566
1934 5506
1935 5661
1936 5384
1937 5308
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4517
1944 4745
1945 20421
1946 53739
1947 64968
1948 70729
1949 62805
1950 85750
1951 103810
1952 108147
1953 108914
1954 105913
1955 108541
1956 107005
1957 111515
1958 109458
1959 109989
1960 112211
1961 120166
1962 125670
1963 141520
1964 162087
1965 176641
1966 179755
1967 191500
1968 207844
1969 215073
1970 218977
1971 222879
1972 227517
1973 230632
1974 234512
1975 248227
1976 250221
1977 249515
1978 257815
1979 265085
1980 266831
1981 271178
1982 282707
1983 294300
1984 302211
1985 318404
1986 330876
1987 346771
1988 363010
1989 376989
1990 382016
1991 379749
1992 381343
1993 388827
1994 400511
1995 409625
1996 419471
1997 417122
1998 434646
1999 451763
2000 488211
2001 500923
2002 518890
2003 546350
2004 588569
2005 647531
2006 692565
2007 730428
2008 777703
2009 817319
2010 879694
2011 956348
2012 1022134
2013 1073167
2014 1127019
2015 1169440
2016 1203610
2017 1227460
2018 1271231
2019 1332154
2020 1528412
2021 1673200
2022 1674280
2023 1587923
2024 1629470
2025 703790
2026 73
2027 1

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36,484,805 results

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Page 1
Analysis of folded structure and folding thermodynamics in heterogeneous-backbone proteomimetics.
Santhouse JR, Rao SR, Horne WS. Santhouse JR, et al. Methods Enzymol. 2021;656:93-122. doi: 10.1016/bs.mie.2021.04.009. Epub 2021 May 3. Methods Enzymol. 2021. PMID: 34325801 Free PMC article. Review.
Here, we discuss some considerations encountered in the characterization of high-resolution folded structure as well as folding thermodynamics of protein-like artificial backbones. We provide an overview of the use of X-ray crystallography and NMR spectroscopy in such syst …
Here, we discuss some considerations encountered in the characterization of high-resolution folded structure as well as folding thermodyn …
An "Onion-like" Model of Protein Unfolding: Collective versus Site Specific Approaches.
Politou AS, Pastore A, Temussi PA. Politou AS, et al. Chemphyschem. 2022 Jan 5;23(1):e202100520. doi: 10.1002/cphc.202100520. Epub 2021 Oct 13. Chemphyschem. 2022. PMID: 34549492 Review.
In this review, we revisit the importance of gaining site-specific information on the unfolding process. We focus on nuclear magnetic resonance, as this is the main technique able to provide site-specific information. ...
In this review, we revisit the importance of gaining site-specific information on the unfolding process. We focus on nuclear magne …
Real-time protein NMR spectroscopy and investigation of assisted protein folding.
Kumar A, Balbach J. Kumar A, et al. Biochim Biophys Acta. 2015 Oct;1850(10):1965-72. doi: 10.1016/j.bbagen.2014.12.003. Epub 2014 Dec 11. Biochim Biophys Acta. 2015. PMID: 25497212 Review.
SCOPE OF REVIEW: Various chaperone interactions can guide the protein-folding reaction and thus are important for protein structure formation, stability, and activity of their substrates. ...Methodologically, it provides in-depth understanding o …
SCOPE OF REVIEW: Various chaperone interactions can guide the protein-folding reaction and thus are important for pr …
Pharmaceutical Hydrates Analysis-Overview of Methods and Recent Advances.
Jurczak E, Mazurek AH, Szeleszczuk Ł, Pisklak DM, Zielińska-Pisklak M. Jurczak E, et al. Pharmaceutics. 2020 Oct 11;12(10):959. doi: 10.3390/pharmaceutics12100959. Pharmaceutics. 2020. PMID: 33050621 Free PMC article. Review.
This has been performed in order to facilitate the choice of an appropriate method depending on the type of the structural feature that is to be analyzed, that is, degree of hydration, crystal structure and dynamics, and (de)hydration kinetics. The presented techniq …
This has been performed in order to facilitate the choice of an appropriate method depending on the type of the structural feature …
Structural characterization of the thermal unfolding pathway of human VEGFR1 D2 domain.
Diana D, Di Stasi R, García-Viñuales S, De Rosa L, Isernia C, Malgieri G, Milardi D, D'Andrea LD, Fattorusso R. Diana D, et al. FEBS J. 2022 Mar;289(6):1591-1602. doi: 10.1111/febs.16246. Epub 2021 Nov 18. FEBS J. 2022. PMID: 34689403 Free PMC article.
Thus, the comprehension of protein folding mechanisms represents an important complement to protein structure and function, crucial to determine the structural basis of protein misfolding. In this context, thermal unfolding studies repres …
Thus, the comprehension of protein folding mechanisms represents an important complement to protein structure and function, cr …
Structure of an intermediate state in protein folding and aggregation.
Neudecker P, Robustelli P, Cavalli A, Walsh P, Lundström P, Zarrine-Afsar A, Sharpe S, Vendruscolo M, Kay LE. Neudecker P, et al. Science. 2012 Apr 20;336(6079):362-6. doi: 10.1126/science.1214203. Science. 2012. PMID: 22517863
To gain insight, we used relaxation dispersion nuclear magnetic resonance spectroscopy to determine the structure of a low-populated, on-pathway folding intermediate of the A39V/N53P/V55L (A, Ala; V, Val; N, Asn; P, Pro; L, Leu) Fyn SH3 domain. ...
To gain insight, we used relaxation dispersion nuclear magnetic resonance spectroscopy to determine the structur …
Thermal unfolding of calreticulin. Structural and thermodynamic characterization of the transition.
Decca MB, Borioli GA, Durand ES, Moreschi A, Hallak ME, Montich GG. Decca MB, et al. Biochim Biophys Acta Proteins Proteom. 2019 Mar;1867(3):175-183. doi: 10.1016/j.bbapap.2018.12.002. Epub 2018 Dec 13. Biochim Biophys Acta Proteins Proteom. 2019. PMID: 30553047
We studied the thermal transitions of monomers and oligomers of CRT by differential scanning calorimetry (DSC), circular dichroism (CD) and Fourier transform infrared spectroscopy (FTIR) in the presence and absence of Ca(2+). ...
We studied the thermal transitions of monomers and oligomers of CRT by differential scanning calorimetry (DSC), circ …
Polyols, increasing global stability of cytochrome c, destabilize the thermal unfolding intermediate.
Naidu KT, Prabhu NP. Naidu KT, et al. J Biomol Struct Dyn. 2022;40(21):11216-11228. doi: 10.1080/07391102.2021.1956593. Epub 2021 Jul 24. J Biomol Struct Dyn. 2022. PMID: 34308796
Most of the secondary structure and the native heme-ligation were intact in the intermediate state of the protein. Denaturants, urea and guanidinium hydrochloride, and ionic salt destabilizes the intermediate and drive the protein to follow two-state transition. The …
Most of the secondary structure and the native heme-ligation were intact in the intermediate state of the protein. Denaturants …
Pressure-temperature folding landscape in proteins involved in neurodegenerative diseases and cancer.
Cordeiro Y, Foguel D, Silva JL. Cordeiro Y, et al. Biophys Chem. 2013 Dec 15;183:9-18. doi: 10.1016/j.bpc.2013.06.002. Epub 2013 Jun 14. Biophys Chem. 2013. PMID: 23849959 Free article. Review.
HHP has long been used to dissociate multimeric proteins and protein aggregates and allows investigation of intermediate folding states, some of which are formed by proteins involved in human degenerative diseases, such as spongiform encephalopathies and Parkinson's disease, as w …
HHP has long been used to dissociate multimeric proteins and protein aggregates and allows investigation of intermediate folding states, som …
36,484,805 results
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