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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 69
1946 176
1947 176
1948 156
1949 190
1950 369
1951 400
1952 464
1953 516
1954 690
1955 767
1956 684
1957 788
1958 892
1959 765
1960 691
1961 786
1962 714
1963 812
1964 1082
1965 865
1966 853
1967 1061
1968 1325
1969 1461
1970 1510
1971 1597
1972 1654
1973 1547
1974 1655
1975 1435
1976 1186
1977 1158
1978 1137
1979 1120
1980 1102
1981 1086
1982 1274
1983 1218
1984 1363
1985 1357
1986 1308
1987 1172
1988 1229
1989 1188
1990 1188
1991 1161
1992 1104
1993 1141
1994 1090
1995 1122
1996 1089
1997 1051
1998 997
1999 996
2000 924
2001 940
2002 903
2003 926
2004 881
2005 886
2006 917
2007 853
2008 836
2009 875
2010 998
2011 932
2012 936
2013 827
2014 783
2015 745
2016 646
2017 721
2018 645
2019 295
2020 5
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68,852 results
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Page 1
Co-regulatory networks of human serum proteins link genetics to disease.
Emilsson V, et al. Science 2018. PMID 30072576 Free PMC article.
Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were measured in the serum of 5457 Icelanders over 65 years of age. ...
Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained lar
Networks of blood proteins in the neuroimmunology of schizophrenia.
Jeffries CD, et al. Transl Psychiatry 2018 - Clinical Trial. PMID 29875399 Free PMC article.
We analyzed baseline blood plasma samples with a Luminex platform from 72 subjects meeting criteria for a psychosis clinical high-risk syndrome; 32 subjects converted to a diagnosis of psychotic disorder within two years while 40 other subjects did not. ...Graph differences were largely driven by proteins regulating tissue remodeling (e.g. blood-brain barrier). In more detail, certain sets of antithetical proteins were highly correlated in unaffected subjects (e.g. ...
We analyzed baseline blood plasma samples with a Luminex platform from 72 subjects meeting criteria for a psychosis clinical high-ris …
Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery
Wewer Albrechtsen NJ, et al. Cell Syst 2018. PMID 30528273 Free article.
The main classes of significantly altered proteins were markers of systemic inflammation and those involved in lipid metabolism. ...A group of inflammation-related proteins showed distinct inverse relationships to proteins consistently associated with insulin sensitivity....
The main classes of significantly altered proteins were markers of systemic inflammation and those involved in lipid metabolism. ...A …
A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.
Niewczas MA, et al. Nat Med 2019. PMID 31011203 Free PMC article.
To study this, we examined 194 circulating inflammatory proteins in subjects from three independent cohorts with type 1 and type 2 diabetes. ...All these proteins had a systemic, non-kidney source. Our prospective study findings provide strong evidence that KRIS proteins contribute to the inflammatory process underlying end-stage renal disease development in both types of diabetes. ...
To study this, we examined 194 circulating inflammatory proteins in subjects from three independent cohorts with type 1 and type 2 di …
Relationship of epitope glycosylation and other properties of blood group proteins to the immunogenicity of blood group antigens.
Howe JG and Stack G. Transfusion 2018. PMID 29770450
RESULTS: The immunogenicities of non-RhD polypeptide antigens were directly related to the total and ectodomain sizes of their carrier proteins. ...The immunogenicity of blood group antigens was positively related to total and ectodomain sizes of blood group proteins and negatively related to antigen site density. ...
RESULTS: The immunogenicities of non-RhD polypeptide antigens were directly related to the total and ectodomain sizes of their carrier pr
The Interplay Between Blood Proteins, Complement, and Macrophages on Nanomedicine Performance and Responses.
Moghimi SM, et al. J Pharmacol Exp Ther 2019 - Review. PMID 30940695
The majority of blood biomolecules bind nonspecifically to nanoparticles. On the other hand, biomolecules such as pattern-recognition complement-sensing proteins may recognize some structural determinants of the pristine surface, causing complement activation. Adsorption of nonspecific blood proteins could also recruit natural antibodies and initiate complement activation, and this seems to be a global process with many preclinical and clinical nanomedicines. ...
The majority of blood biomolecules bind nonspecifically to nanoparticles. On the other hand, biomolecules such as pattern-recognition …
Undulating changes in human plasma proteome profiles across the lifespan
Lehallier B, et al. Nat Med 2019. PMID 31806903
Blood from young mice reverses aspects of aging and disease across multiple tissues(2-10), which supports a hypothesis that age-related molecular changes in blood could provide new insights into age-related disease biology. We measured 2,925 plasma proteins from 4,263 young adults to nonagenarians (18-95 years old) and developed a new bioinformatics approach that uncovered marked non-linear alterations in the human plasma proteome with age. ...
Blood from young mice reverses aspects of aging and disease across multiple tissues(2-10), which supports a hypothesis that age-relat
Nontoxic silver nanocluster-induced folding, fibrillation, and aggregation of blood plasma proteins.
Maghsudi M, et al. Int J Biol Macromol 2018. PMID 30067958
Therefore, the interaction of NCs with proteins and the cellular implications can be therapeutically of great importance. Adsorption of human blood proteins on NCs has been methodically investigated. ...Then, interactions with human blood proteins, such as immunoglobulin, albumin, and insulin were investigated using various experimental approaches. ...
Therefore, the interaction of NCs with proteins and the cellular implications can be therapeutically of great importance. Adsorption …
Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission
Tasaki S, et al. Nat Commun 2018. PMID 30013029 Free PMC article.
We report a longitudinal monitoring of the drug response at multi-omics levels in the peripheral blood of patients with RA. Our data reveal that drug treatments alter the molecular profile closer to that of HCs at the transcriptome, serum proteome, and immunophenotype level. ...
We report a longitudinal monitoring of the drug response at multi-omics levels in the peripheral blood of patients with RA. Our data …
Serum biomarkers for diagnosis and prediction of type 1 diabetes
Yi L, et al. Transl Res 2018 - Review. PMID 30144424 Free PMC article.
The advent of high-throughput and sensitive "-omics" technologies for the study of proteins, nucleic acids, and metabolites have allowed large scale profiling of protein expression and gene changes in T1D patients relative to disease-free controls. ...
The advent of high-throughput and sensitive "-omics" technologies for the study of proteins, nucleic acids, and metabolites have allo …
68,852 results
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