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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 8
1997 19
1998 28
1999 48
2000 35
2001 49
2002 32
2003 57
2004 53
2005 50
2006 53
2007 56
2008 40
2009 10
2010 8
2011 18
2012 31
2013 34
2014 28
2015 35
2016 38
2017 32
2018 38
2019 15
2020 0
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748 results
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Page 1
Effects of Nel-like molecule-1 and bone morphogenetic protein 2 combination on rat pulp repair.
Wu J, et al. J Mol Histol 2019. PMID 30937700
Recent studies have suggested that NELL-1 can synergistically increase bone formation and regeneration with bone morphogenetic protein 2 (BMP2) and inhibit adverse effects induced by BMP2. This study aimed to evaluate the combined effects of NELL-1 and BMP2 on rat pulp repair. The experiment used healthy non-carious maxillary first molars from 60 Wistar rats. ...
Recent studies have suggested that NELL-1 can synergistically increase bone formation and regeneration with bone morphogenetic protein
The expression analysis of Bmpr1a and Bmp2 during hindgut development in rat embryos with anorectal malformations.
Tang XB, et al. Exp Mol Pathol 2016. PMID 27477499
The expression of Bmpr1a and Bmp2 was evaluated in normal rat embryos (n=213) and ARM embryos (n=236) from GD14 to GD16. Immunohistochemical staining revealed, in normal embryos, that Bmpr1a and Bmp2 was mainly expressed on the epithelium of the urorectal septum (URS) and the cloacal membrane (CM) on GD14 and GD15. ...In ARM embryos, the epithelium of the hindgut and URS demonstrated faint immunostaining for Bmpr1a and Bmp2. Analyses by Western blot and Real-time PCR revealed that Bmpr1a and Bmp2 protein and mRNA expression were significantly decreased in the ARM hindgut compared with normal hindgut on GD14 and GD15 (P<0.05). ...
The expression of Bmpr1a and Bmp2 was evaluated in normal rat embryos (n=213) and ARM embryos (n=236) from GD14 to GD16. Immun …
Bone morphogenic protein-2 regulates the myogenic differentiation of PMVECs in CBDL rat serum-induced pulmonary microvascular remodeling.
Liu C, et al. Exp Cell Res 2015. PMID 26071935
Additionally, it has been shown that bone morphogenic protein-2 (BMP2), via the control of protein expression, may regulate cell differentiation including cardiomyocyte differentiation, neuronal differentiation and odontoblastic differentiation. In this study, we observed that common bile duct ligation (CBDL)-rat serum induced the upregulation of the expression of several myogenic proteins (SM-α-actin, calponin, SM-MHC) and enhanced the expression levels of BMP2 mRNA and protein in PMVECs. ...
Additionally, it has been shown that bone morphogenic protein-2 (BMP2), via the control of protein expression, may regu …
Osteogenic effect of bone marrow mesenchymal stem cell-derived exosomes on steroid-induced osteonecrosis of the femoral head
Fang S, et al. Drug Des Devel Ther 2018. PMID 30587927 Free PMC article.
Among the DEGs, osteogenesis-related genes, including Bmp2, Bmp6, Bmpr1b, Mmp9, and Sox9, may play important roles in SFHN. Furthermore, the DEGs were mainly involved in immune response, osteoblast differentiation, and in the transforming growth factor-β/bone morphogenetic protein signaling pathway. The level of the SOX9 protein was upregulated by Exos, and Sox9 silencing significantly decreased the osteogenic effect of BMSC Exos. ...
Among the DEGs, osteogenesis-related genes, including Bmp2, Bmp6, Bmpr1b, Mmp9, and Sox9, may play important roles in SFHN. Furthermo …
Sp1 Plays an Important Role in Vascular Calcification Both In Vivo and In Vitro
Zhang X, et al. J Am Heart Assoc 2018. PMID 29572322 Free PMC article.
There is evidence that specific protein 1 (Sp1) directly stimulates the transcription of bone morphogenetic protein 2 (BMP2) and that BMP2 plays a key role in the calcification process in the BMP2-expressing F9 cell model system. ...Moreover, Sp1 can activate BMP2 transcription by binding to the Sp1-binding element of the BMP2 promoter. CONCLUSIONS: Overall, elevated Sp1 exerts a pro-apoptotic effect, promoting BMP2 transcription and further accumulating vascular calcification. ...
There is evidence that specific protein 1 (Sp1) directly stimulates the transcription of bone morphogenetic protein 2 (BMP2
Hyaluronan negatively regulates vascular calcification involving BMP2 signaling.
Kong Y, et al. Lab Invest 2018. PMID 29785051 Free article.
Similarly, HA treatment decreased ALP activity and expression of bone-related molecules including Runx2, BMP2 and Msx2. By contrast, inhibition of HA synthesis by 4-methylumbelliferone (4MU) promoted calcification of rat VSMCs. ...Furthermore, we found that BMP2 signaling was inhibited in VSMCs after HA treatment. Recombinant BMP2 enhanced high calcium and phosphate-induced VSMC calcification, which can be blocked by HA treatment. ...
Similarly, HA treatment decreased ALP activity and expression of bone-related molecules including Runx2, BMP2 and Msx2. By contrast, …
[Expression of BMP2/Smad1/Runx2 Signal Pathway in Renal Artery of Rat with Vascular Calcification].
Qin Chun-mei , et al. Sichuan Da Xue Xue Bao Yi Xue Ban 2016. PMID 27263290 Chinese.
OBJECTIVE: To investigate the activation and its role of bone morphogenetic protein 2 (BMP2)/Smad1/Runt-related transcription factor 2 (Runx2) signal pathway in renal artery of rat models with vascular calcification. ...Real time-PCR was applied to detect the expression of BMP2, Smad1, Runx2 mRNA, and immunohistochemistry was used to measure the protein levels of BMP2, Smad1, Runx2, α-smooth muscle actin (α-SMA). ...
OBJECTIVE: To investigate the activation and its role of bone morphogenetic protein 2 (BMP2)/Smad1/Runt-related transcription …
BMP2 expression in the adult rat brain.
Sato T, et al. J Comp Neurol 2010. PMID 20886619
Bone morphogenetic protein-2 (BMP2) is a member of the transforming growth factor-β (TGF-β) superfamily and plays important roles in multiple biological events. ...We thus investigated BMP2 expression in the adult rat CNS by using immunohistochemistry. Here we show that BMP2 is widely expressed throughout the adult CNS. ...
Bone morphogenetic protein-2 (BMP2) is a member of the transforming growth factor-β (TGF-β) superfamily and plays important ro …
Combination treatment of adipose-derived stem cells and adiponectin attenuates pulmonary arterial hypertension in rats by inhibiting pulmonary arterial smooth muscle cell proliferation and regulating the AMPK/BMP/Smad pathway
Luo L, et al. Int J Mol Med 2018. PMID 29115380 Free PMC article.
The influence of APN and specific inhibitors on the levels of bone morphogenetic protein (BMP), adenosine monophosphate activated protein kinase (AMPK), and small mothers against decapentaplegia (Smad) pathways was detected by western blot analysis. ...This effect was weakened by addition of the AMPK inhibitor (compound C) and BMP2 inhibitor (noggin). Therefore, combination treatment with ADSCs and APN effectively attenuated PAH in rats by inhibiting PASMC proliferation and regulating the AMPK/BMP/Smad pathway....
The influence of APN and specific inhibitors on the levels of bone morphogenetic protein (BMP), adenosine monophosphate activated …
The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures.
Santamaría CG, et al. Toxicol Lett 2019. PMID 30599193
Nest breakdown, follicular assembly and the expression of several regulators of these processes (p27, Foxl2, Sox9, Bmp2, Cyp19 and Fst) were evaluated. ...
Nest breakdown, follicular assembly and the expression of several regulators of these processes (p27, Foxl2, Sox9, Bmp2, Cyp19 and Fs …
748 results
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