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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1963 1
1965 8
1966 8
1967 15
1968 15
1969 16
1970 21
1971 21
1972 13
1973 15
1974 14
1975 22
1976 15
1977 18
1978 15
1979 28
1980 26
1981 20
1982 23
1983 25
1984 31
1985 20
1986 15
1987 22
1988 18
1989 12
1990 14
1991 26
1992 21
1993 20
1994 20
1995 27
1996 16
1997 15
1998 7
1999 11
2000 12
2001 9
2002 14
2003 11
2004 18
2005 17
2006 17
2007 20
2008 22
2009 22
2010 23
2011 21
2012 10
2013 17
2014 27
2015 19
2016 12
2017 21
2018 21
2019 11
2020 0
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942 results
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Page 1
Bone marrow lesions in osteoarthritis: What lies beneath.
Alliston T, et al. J Orthop Res 2018 - Review. PMID 29266428 Free article.
Changes in subchondral bone are recognized as a hallmark of OA, but are normally associated with late-stage disease when degeneration is well established. However, early changes such as Bone Marrow Lesions (BMLs) in OA are a relatively recent discovery. BMLs are patterns from magnetic resonance images (MRI) that have been linked with pain and cartilage degeneration. ...
Changes in subchondral bone are recognized as a hallmark of OA, but are normally associated with late-stage disease when degeneration …
The emerging role of bone marrow adipose tissue in bone health and dysfunction.
Ambrosi TH and Schulz TJ. J Mol Med (Berl) 2017 - Review. PMID 29101431
Replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow is a conserved physiological process among mammals. ...Intriguingly, several important molecular characteristics of bone marrow adipose tissue (BMAT) are distinct from the classical depots of white and brown fat tissue. ...
Replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow is a conserved physiological process amo …
Bone Marrow Microenvironment as a Regulator and Therapeutic Target for Prostate Cancer Bone Metastasis.
Park SH, et al. Calcif Tissue Int 2018 - Review. PMID 29094177 Free PMC article.
Furthermore, bone metastases produce multiple skeletal complications, including bone pain that impairs the patients' quality of life. ...Although the exact mechanisms through which prostate cancer metastasizes to bone are unclear, growing evidence suggests that the bone marrow microenvironment, particularly its hematopoietic activity, is a significant mediator of prostate cancer bone tropism. ...
Furthermore, bone metastases produce multiple skeletal complications, including bone pain that impairs the patients' quality o …
Cerebral Blood Flow and Marrow Diffusion Alterations in Children with Sickle Cell Anemia after Bone Marrow Transplantation and Transfusion.
Whitehead MT, et al. AJNR Am J Neuroradiol 2018. PMID 30309846 Free article.
We have observed marrow diffusion and arterial spin-labeling perfusion changes in sickle cell anemia following bone marrow transplantation. ...Territorial CBF, whole-brain average CBF, and marrow ADC values were compared for changes before and after either bone marrow transplantation or transfusion. ...
We have observed marrow diffusion and arterial spin-labeling perfusion changes in sickle cell anemia following bone marrow
Targeting the Bone Marrow Microenvironment.
Moschetta M, et al. Cancer Treat Res 2016 - Review. PMID 27696259
Unprecedented advances in multiple myeloma (MM) therapy during the last 15 years are predominantly based on our increasing understanding of the pathophysiologic role of the bone marrow (BM) microenvironment. ...
Unprecedented advances in multiple myeloma (MM) therapy during the last 15 years are predominantly based on our increasing understanding of …
The Role of the Local Bone Marrow Renin-Angiotensin System in Multiple Myeloma.
Saka B, et al. Turk J Haematol 2019. PMID 31042345 Free PMC article.
MATERIALS AND METHODS: Bone marrow AGTR1 mRNA levels of 39 MM patients and 15 healthy controls were analyzed with quantitative RT-PCR. ...Patients with severe-diffuse bone marrow infiltration showed higher bone marrow VEGF, fVIIIrAg, CD34, and AGTR1 mRNA levels when compared to other patients. ...
MATERIALS AND METHODS: Bone marrow AGTR1 mRNA levels of 39 MM patients and 15 healthy controls were analyzed with quantitative …
[Bone Marrow Microenvironment and Myelodysplastic Syndromes--Review].
Zhang GC, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2016 - Review. PMID 26913439 Chinese.
Myelodysplastic syndromes (MDS) are a group of bone marrow failure diseases. The bone marrow microenvironment consists of bone marrow stromal cells (BMSC), growth factors and cytokines. ...In this review the abnormality of MDS bone marrow microenvironment is summarized briefly....
Myelodysplastic syndromes (MDS) are a group of bone marrow failure diseases. The bone marrow microenvironment co …
Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis.
Manolagas SC and Jilka RL. N Engl J Med 1995 - Review. PMID 7816067
Both osteoblasts and osteoclasts are derived from progenitors that reside in the bone marrow; osteoblasts belong to the mesenchymal lineage of the marrow stroma, and osteoclasts to the hematopoietic lineage. ...The cellular activity of the bone marrow is also altered by the process of aging. Specifically, senescence may decrease the ability of the marrow to form osteoblast precursors. ...
Both osteoblasts and osteoclasts are derived from progenitors that reside in the bone marrow; osteoblasts belong to the mesenc …
Chronic Kidney Disease Is Associated With Greater Bone Marrow Adiposity.
Woods GN, et al. J Bone Miner Res 2018. PMID 30075054 Free PMC article.
Bone marrow adiposity is associated with aging, osteoporosis, and reduced hematopoiesis, as well as anorexia nervosa, but little is known about the underlying mechanisms that affect marrow adiposity. ...CKD stage 3b or worse was associated with greater bone marrow adiposity; this association may be partially mediated by sclerostin. © 2018 American Society for Bone and Mineral Research....
Bone marrow adiposity is associated with aging, osteoporosis, and reduced hematopoiesis, as well as anorexia nervosa, but litt
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