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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1978 1
1981 1
1983 1
1984 2
1985 2
1986 3
1987 1
1988 1
1989 3
1990 1
1991 2
1994 1
1995 4
1996 1
1997 2
1998 3
1999 1
2000 2
2001 3
2002 3
2003 9
2004 2
2005 4
2006 5
2007 5
2008 1
2009 4
2010 6
2011 3
2012 5
2013 4
2014 4
2015 4
2016 1
2017 1
2018 3
2019 1
2020 0
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92 results
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Page 1
Multiscale alterations in bone matrix quality increased fragility in steroid induced osteoporosis.
Karunaratne A, et al. Bone 2016. PMID 26657825 Free PMC article.
This rapid increase in bone fracture risk is largely independent of bone loss (quantity), and must therefore arise from degradation of the quality of the bone matrix at the micro- and nanoscale. ...Here we demonstrate alterations in the nanostructural parameters of the mineralized fibrillar collagen matrix, which affect bone quality, and develop a model linking these to increased fracture risk in glucocorticoid induced osteoporosis. ...
This rapid increase in bone fracture risk is largely independent of bone loss (quantity), and must therefore arise from degrad …
The role of collagen in bone strength.
Viguet-Carrin S, et al. Osteoporos Int 2006 - Review. PMID 16341622
Different determinants of bone quality are interrelated, especially the mineral and collagen, and analysis of their specific roles in bone strength is difficult. ...These modifications of collagen are age-related and may impair the mechanical properties of bone. To illustrate the role of the crosslinking process of collagen in bone strength, clinical disorders associated with bone collagen abnormalities and bone fragility, such as osteogenesis imperfecta and osteoporosis, are described....
Different determinants of bone quality are interrelated, especially the mineral and collagen, and analysis of their specific roles in …
Dynamics of bone tissue formation in tooth extraction sites. An experimental study in dogs.
Cardaropoli G, et al. J Clin Periodontol 2003. PMID 12956657
After seven days this clot was in part replaced with a provisional matrix (PCT). On day 14, the tissue of the socket was comprised of PM and woven bone. ...CONCLUSION: The healing of an extraction socket involved a series of events including the formation of a coagulum that was replaced by (i) a provisional connective tissue matrix, (ii) woven bone, and (iii) lamellar bone and BM. ...
After seven days this clot was in part replaced with a provisional matrix (PCT). On day 14, the tissue of the socket was comprised of …
Consideration of bone regeneration effect of stem cells: comparison between adipose-derived stem cells and demineralized bone matrix.
Han DS, et al. J Craniofac Surg 2014. PMID 24406576
BACKGROUND: Currently, many studies have sought to address the regeneration of extensive bone defects using stem cells. Here, the authors injected adipose-derived stem cells and demineralized bone matrix (DBM) into areas of bone defect in rabbits and compared their effect on bone regeneration to study the clinical usefulness of stem cells. ...Overall, bone regeneration was weakest in the control group, whereas other groups of defects showed distinct bone regeneration. ...
BACKGROUND: Currently, many studies have sought to address the regeneration of extensive bone defects using stem cells. Here, the aut …
Role of matrix behavior in compressive fracture of bovine cortical bone.
Mayya A, et al. Phys Rev E 2017. PMID 29347807
In compressive fracture of dry plexiform bone, we examine the individual roles of overall mean porosity, the connectivity of the porosity network, and the elastic as well as the failure properties of the nonporous matrix, using a random spring network model (RSNM). ...To validate the porosity-based RSNM model with available experimental data, bone-specific failure strain thresholds for the ideal matrix of similar elastic properties were estimated to be within 60% of each other. ...
In compressive fracture of dry plexiform bone, we examine the individual roles of overall mean porosity, the connectivity of the poro …
Deletion of OPN in BSP knockout mice does not correct bone hypomineralization but results in high bone turnover.
Bouleftour W, et al. Bone 2019. PMID 30529011
High bone formation and resorption parameters, and high cortical porosity in DKO mice suggest an active bone modeling/remodeling, in the absence of two key regulators of bone cell performance. This first double KO of SIBLING proteins thus results in a singular, non-trivial phenotype leading to reconsider the interpretation of each single KO, concerning in particular matrix mineralization and the regulation of bone cell activity....
High bone formation and resorption parameters, and high cortical porosity in DKO mice suggest an active bone modeling/remodeli …
[Bone matrix production in osteosarcoma].
Schulz A, et al. Verh Dtsch Ges Pathol 1998 - Review. PMID 10095426 German.
Osteosarcomas produce an extracellular matrix (ECM), called tumor osteoid, which is also the microscopic hallmark of these tumors. ...The key to the solution of this problem is the immunohistochemical use of antibodies against bone matrix components. Matrix-immunohistochemistry using polyclonal and monoclonal antibodies against COL-I-C-peptide, Osteopontin, Osteonectin, Osteocalcin, and Decorin have proved to be a useful tool for the differentiation of osteoid in a series of 20 osteosarcomas with different variants of osteoid formation. ...
Osteosarcomas produce an extracellular matrix (ECM), called tumor osteoid, which is also the microscopic hallmark of these tumors. .. …
Fragility fractures in men with idiopathic osteoporosis are associated with undermineralization of the bone matrix without evidence of increased bone turnover.
Fratzl-Zelman N, et al. Calcif Tissue Int 2011 - Clinical Trial. PMID 21318401
The shift toward lower mineral content in the bone matrix in combination with reduced indices of bone formation and bone resorption suggests an inherent mineralization defect leading to undermineralized bone matrix, which might contribute to the susceptibility to fragility fractures of the patients. The alteration in bone material might be related to osteoblastic dysfunction and seems fundamentally different from that in high bone turnover osteoporosis with a negative bone balance....
The shift toward lower mineral content in the bone matrix in combination with reduced indices of bone formation and …
Bone quality issues an matrix properties in OP cancellous bone.
Zioupos P, et al. Stud Health Technol Inform 2008 - Review. PMID 18431857
There is increasing evidence nowadays that diseases or conditions, like osteoporosis (OP), which are conventionally defined in terms of bone quantity/mass, are also associated with concomitant changes at the bone matrix level. ...The results showed that changes in porosity (Bone volume/Tissue volume) are accompanied by changes in mineral content and in the hardness of individual trabeculae. ...
There is increasing evidence nowadays that diseases or conditions, like osteoporosis (OP), which are conventionally defined in terms of b
Effects of fatigue on microstructure and mechanical properties of bone organic matrix under compression.
Trębacz H, et al. Australas Phys Eng Sci Med 2013. PMID 23393006 Free PMC article.
The aim of the study was to investigate whether a fatigue induced weakening of cortical bone was revealed in microstructure and mechanical competence of demineralized bone matrix. ...The effect of fatigue depended on the type of the bone, being more pronounced in the plexiform than in Haversian tissue. Demineralized bone matrix was anisotropic under compressive loads in both types of cortical structure. ...
The aim of the study was to investigate whether a fatigue induced weakening of cortical bone was revealed in microstructure and mecha …
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