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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1995 2
1996 32
1997 93
1998 121
1999 172
2000 166
2001 188
2002 201
2003 227
2004 245
2005 280
2006 349
2007 322
2008 380
2009 471
2010 500
2011 576
2012 622
2013 665
2014 600
2015 553
2016 533
2017 559
2018 458
2019 194
2020 2
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7,512 results
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Page 1
Titanium Mesh Grafting Combined with Recombinant Human Bone Morphogenetic Protein 2 for Alveolar Reconstruction.
Herford AS, et al. Oral Maxillofac Surg Clin North Am 2019 - Review. PMID 30852177
There are several methods of regenerating the maxillary and mandibular ridge to achieve orthoalveolar form with bone grafting procedures, including block onlay grafting and guided bone regeneration. ...With the advent of other adjuncts, such as resorbable membranes, and growth factors, such as recombinant human bone morphogenetic protein 2, the predictability of the procedure has increased and a wide variety of defects can be restored using this technology....
There are several methods of regenerating the maxillary and mandibular ridge to achieve orthoalveolar form with bone grafting procedu …
A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2.
James AW, et al. Tissue Eng Part B Rev 2016 - Review. PMID 26857241 Free PMC article.
Bone morphogenetic protein-2 (BMP-2) is currently the only Food and Drug Administration (FDA)-approved osteoinductive growth factor used as a bone graft substitute. However, with increasing clinical use of BMP-2, a growing and well-documented side effect profile has emerged. This includes postoperative inflammation and associated adverse effects, ectopic bone formation, osteoclast-mediated bone resorption, and inappropriate adipogenesis. ...
Bone morphogenetic protein-2 (BMP-2) is currently the only Food and Drug Administration (FDA)-approved os
Bone morphogenetic protein-2 and tumor growth: Diverse effects and possibilities for therapy.
Tian H, et al. Cytokine Growth Factor Rev 2017 - Review. PMID 28109670
Concern regarding safety with respect to the clinical use of human bone morphogenetic protein-2 (BMP-2) has become an increasingly controversial topic. The role of BMP-2 in carcinogenesis is of particular concern. Although there have been many studies of this topic, the results have been contradictory and confusing. ...
Concern regarding safety with respect to the clinical use of human bone morphogenetic protein-2 (BMP-2) h …
Bone morphogenetic protein-2 and bone therapy: successes and pitfalls.
Poon B, et al. J Pharm Pharmacol 2016 - Review. PMID 26727402
OBJECTIVES: Bone morphogenetic proteins (BMPs), more specifically BMP-2, are being increasingly used in orthopaedic surgery due to advanced research into osteoinductive factors that may enhance and improve bone therapy. ...This review explores the use of BMP-2 and its successes, pitfalls and future prospects in bone therapy. METHODS: The PubMed database was consulted to compile this review. ...
OBJECTIVES: Bone morphogenetic proteins (BMPs), more specifically BMP-2, are being increasingly used in orthopaedic sur …
A review on carrier systems for bone morphogenetic protein-2.
Agrawal V and Sinha M. J Biomed Mater Res B Appl Biomater 2017 - Review. PMID 26728994
Bone morphogenetic protein-2 (BMP-2) has unique bone regeneration property. The powerful osteoinductive nature makes it considered as second line of therapy in nonunion bone defect. ...Along with these biomaterials, the attempts of protein modification by adding some functional group to BMP-2 or extracting functional peptides from the protein to achieve the desired effect, is also evaluated. © 2016 Wiley Periodicals, Inc. ...
Bone morphogenetic protein-2 (BMP-2) has unique bone regeneration property. The powerful osteoindu
A doxycycline inducible, adenoviral bone morphogenetic protein-2 gene delivery system to bone.
Bara JJ, et al. J Tissue Eng Regen Med 2018. PMID 27957814
Bone morphogenetic protein-2 (BMP-2) transgene expression could be effectively tuned by modification of the doxycycline concentration. ...In AdTetBMP-2 groups, histological analysis revealed significantly more newly formed bone at the defect site compared with controls. ...
Bone morphogenetic protein-2 (BMP-2) transgene expression could be effectively tuned by modification of t
Polymeric electrospun scaffolds for bone morphogenetic protein 2 delivery in bone tissue engineering.
Aragón J, et al. J Colloid Interface Sci 2018. PMID 30029031
HYPOTHESIS: The development of novel scaffolds based on biocompatible polymers is of great interest in the field of bone repair for fabrication of biodegradable scaffolds that mimic the extracellular matrix and have osteoconductive and osteoinductive properties for enhanced bone regeneration. EXPERIMENTS: Polycaprolactone (PCL) and polycaprolactone/polyvinyl acetate (PCL/PVAc) core-shell fibers were synthesised and decorated with poly(lactic-co-glycolic acid) [PLGA] particles loaded with bone morphogenetic protein 2 (BMP2) by simultaneous electrospinning and electrospraying. ...
HYPOTHESIS: The development of novel scaffolds based on biocompatible polymers is of great interest in the field of bone repair for f …
Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2.
Mumcuoglu D, et al. Mater Sci Eng C Mater Biol Appl 2018. PMID 29519439
Bone morphogenetic protein-2 (BMP-2) is a powerful osteoinductive protein; however, there is a need for the development of a safe and efficient BMP-2 release system for bone regeneration therapies. ...In this study, we have developed a novel and versatile BMP-2 delivery system using microspheres from a recombinant protein based on human collagen I (RCP). ...
Bone morphogenetic protein-2 (BMP-2) is a powerful osteoinductive protein; however, there is a nee
Purification of bone morphogenetic protein-2 from refolding mixtures using mixed-mode membrane chromatography.
Gieseler G, et al. Appl Microbiol Biotechnol 2017. PMID 27542381
In this study, we present the development of a process for the purification of recombinant human bone morphogenetic protein-2 (rhBMP-2) using mixed-mode membrane chromatography. ...Different membrane chromatography phases were analyzed for their ability to purify BMP-2. A membrane phase with salt-tolerant properties resulting from mixed-mode ligand chemistry was able to selectively purify BMP-2 dimer from refolding mixtures. ...
In this study, we present the development of a process for the purification of recombinant human bone morphogenetic protein
Gene-activated tissue grafts for sustained bone morphogenetic protein-2 delivery and bone engineering: Is muscle with fascia superior to muscle and fat?
Ren B, et al. J Tissue Eng Regen Med 2018. PMID 28940796
Previously, we have presented an expedited strategy for sustained delivery of bone morphogenetic protein-2 (BMP-2) to bone lesions based on the implantation of gene-activated fat and muscle fragments. ...The tissues were cut into small pieces and cultured for up to 90 days after direct transduction with adenoviral BMP-2 or green fluorescence protein vectors. ...
Previously, we have presented an expedited strategy for sustained delivery of bone morphogenetic protein-2 (BMP- …
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