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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1995 2
1996 32
1997 93
1998 121
1999 172
2000 166
2001 188
2002 201
2003 227
2004 245
2005 280
2006 349
2007 322
2008 380
2009 471
2010 500
2011 576
2012 622
2013 665
2014 600
2015 553
2016 533
2017 559
2018 458
2019 196
2020 3
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7,514 results
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Page 1
Bone morphogenetic protein-2 release profile modulates bone formation in phosphorylated hydrogel.
Olthof MGL, et al. J Tissue Eng Regen Med 2018. PMID 29603878
The optimal release profile of locally delivered bone morphogenetic protein-2 (BMP-2) for safe and effective clinical application is unknown. ...OPF-BP-Ads generated significantly more bone than did all other composites, and the bone formation was 12-fold higher than that of the clinically used ACS. ...
The optimal release profile of locally delivered bone morphogenetic protein-2 (BMP-2) for safe and effective clinical applicat …
Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation.
Croes M, et al. Sci Rep 2018. PMID 29740080 Free PMC article.
Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphogenetic protein (BMP)-2. ...The use of IL-17 may contribute to the development of improved bone graft substitutes....
Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphoge
Clinical Application of Bone Morphogenetic Protein-2 Microcarriers Fabricated by the Cryopolymerization of Gelatin Methacrylate for the Treatment of Radial Fracture in Two Dogs.
Park J, et al. In Vivo 2018. PMID 29695563 Free PMC article.
Bone morphogenetic protein-2 (BMP-2) effectively induces bone healing. However, the efficacy of BMP-2 relies heavily on its delivery vehicle because of its short half-life. We utilized a microcarrier fabricated by the cryopolymerization of gelatin methacrylate (cryoGelMA) infused with bone morphogenetic protein-2 (cryoGelMA-BMP-2) for the sustained and localized release of growth factors. ...
Bone morphogenetic protein-2 (BMP-2) effectively induces bone healing. However, the efficacy of BMP-2 relies heavily on
Tuning the bioactivity of bone morphogenetic protein-2 with surface immobilization strategies.
Chen R, et al. Acta Biomater 2018. PMID 30218780
Bone morphogenetic protein-2 (BMP-2) involved therapy is of great potential for bone regeneration. However, its clinical application is restricted due to the undesirable bioactivity and relevant complications in vivo. ...STATEMENT OF SIGNIFICANCE: Bone morphogenetic protein-2 (BMP-2) is crucial in bone regeneration. However, its clinical application is challenged due to its shorten half-life and supra-physiological dose associated complications. ...
Bone morphogenetic protein-2 (BMP-2) involved therapy is of great potential for bone regeneration. However, its clinica
Bone Tissue Engineering Strategies in Co-Delivery of Bone Morphogenetic Protein-2 and Biochemical Signaling Factors.
Kim S, et al. Adv Exp Med Biol 2018 - Review. PMID 30357626
Administration of bone morphogenetic protein-2 (BMP-2), which is commercially approved by the food and drug administration to damaged bone sites has been investigated for the purpose of bone tissue regeneration. BMP-2 can promote osteoblastic differentiation of mesenchymal stem cells as well as regeneration of bone formation in early phase. ...
Administration of bone morphogenetic protein-2 (BMP-2), which is commercially approved by the food and drug administration to …
Effects of strontium-modified calcium phosphate cement combined with bone morphogenetic protein-2 on osteoporotic bone defects healing in rats.
Tao Z, et al. J Biomater Appl 2018. PMID 29554840
The objective of the present study was to incorporate strontium into calcium phosphate cement combined with a lower single-dose local administration of bone morphogenetic protein-2 to enhance its in vivo biodegradation and bone tissue growth. ...The results from our study demonstrate that combination of a lower single-dose local administration of bone morphogenetic protein-2 and strontium-modified calcium phosphate cement had an additive effect on local bone formation in osteoporosis rats....
The objective of the present study was to incorporate strontium into calcium phosphate cement combined with a lower single-dose local admini …
Use of Bone Morphogenetic Protein-2 in Vertebral Column Tumor Surgery: A National Investigation.
De la Garza Ramos R, et al. World Neurosurg 2018 - Clinical Trial. PMID 29733987
OBJECTIVE: To report the rate of bone morphogenetic protein-2 (BMP-2) use in vertebral column tumor surgery. METHODS: The Nationwide Inpatient Sample database (2012-2014) was queried to identify patients who underwent spinal fusion for vertebral column tumors (primary benign, primary malignant, or metastatic). ...
OBJECTIVE: To report the rate of bone morphogenetic protein-2 (BMP-2) use in vertebral column tumor surgery. METHODS: The Nati …
Bone repair scaffold coated with bone morphogenetic protein-2 for bone regeneration in murine calvarial defect model: Systematic review and quality evaluation.
Zeng JH, et al. Int J Artif Organs 2019. PMID 30905250
Histomorphometric results showed that bone morphogenetic protein-2 enhanced the capacity to regenerate bone considerably. In addition, scaffolds with bone morphogenetic protein-2 resulted in a significant increase in the blood vessel in the new bone. ...This systematic review suggested that bone morphogenetic protein-2 enhanced the capacity to regenerate bone and the angiogenesis in the new bone....
Histomorphometric results showed that bone morphogenetic protein-2 enhanced the capacity to regenerate bone considerabl …
Bone Morphogenetic Proteins 2/4 Are Upregulated during the Early Development of Vascular Calcification in Chronic Kidney Disease.
Wei X, et al. Biomed Res Int 2018. PMID 29850574 Free PMC article.
This study aimed to investigate the role of the bone morphogenetic protein (BMP) signaling pathway in the early development of vascular calcification in CKD. ...The expression levels of BMP-2, BMP-4, bone morphogenetic protein receptor-IA (BMPR-IA), and matrix Gla protein (MGP) in aorta were examined by quantitative real-time polymerase chain reaction and immunohistochemistry. ...
This study aimed to investigate the role of the bone morphogenetic protein (BMP) signaling pathway in the early development of …
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