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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1946 3
1947 3
1948 2
1949 3
1950 1
1951 2
1952 6
1953 1
1954 4
1955 5
1956 3
1957 4
1958 2
1959 2
1960 2
1961 2
1962 1
1963 4
1964 38
1965 62
1966 95
1967 161
1968 97
1969 126
1970 124
1971 128
1972 119
1973 146
1974 137
1975 118
1976 92
1977 79
1978 83
1979 75
1980 69
1981 64
1982 73
1983 68
1984 53
1985 59
1986 91
1987 95
1988 95
1989 162
1990 244
1991 315
1992 281
1993 372
1994 348
1995 333
1996 405
1997 471
1998 454
1999 499
2000 471
2001 428
2002 515
2003 610
2004 611
2005 740
2006 736
2007 798
2008 1023
2009 1124
2010 1346
2011 1411
2012 1431
2013 1503
2014 1477
2015 1396
2016 1326
2017 1432
2018 1364
2019 786
2020 22
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24,030 results
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Page 1
Guided bone regeneration: materials and biological mechanisms revisited.
Elgali I, et al. Eur J Oral Sci 2017 - Review. PMID 28833567 Free PMC article.
Guided bone regeneration (GBR) is commonly used in combination with the installment of titanium implants. The application of a membrane to exclude non-osteogenic tissues from interfering with bone regeneration is a key principle of GBR. ...Experimental data suggest that different modifications of the physicochemical and mechanical properties of membranes may promote bone regeneration. ...
Guided bone regeneration (GBR) is commonly used in combination with the installment of titanium implants. The application of a …
The roles of signaling pathways in bone repair and regeneration.
Majidinia M, et al. J Cell Physiol 2018 - Review. PMID 28590066
Since mesenchymal stem cells (MSCs) and their differentiation during remodeling processes have important roles in bone regeneration, it is believed that understanding molecular signaling pathways involved is crucial to the development of bone implants, bone substitute materials, and cell-based scaffolds for bone regeneration. In this review, we briefly introduce concepts in fracture repair and regeneration following bone injuries, and then discuss the current clinical methods in bone regeneration. ...
Since mesenchymal stem cells (MSCs) and their differentiation during remodeling processes have important roles in bone regeneratio
Osteoinduction of bone grafting materials for bone repair and regeneration.
García-Gareta E, et al. Bone 2015 - Review. PMID 26163110
Regeneration of bone defects caused by trauma, infection, tumours or inherent genetic disorders is a clinical challenge that usually necessitates bone grafting materials. Autologous bone or autograft is still considered the clinical "gold standard" and the most effective method for bone regeneration. ...
Regeneration of bone defects caused by trauma, infection, tumours or inherent genetic disorders is a clinical challenge that u
Parathyroid hormone for bone regeneration.
Wojda SJ and Donahue SW. J Orthop Res 2018 - Review. PMID 29926970 Free article.
The anabolic effect PTH has on bone has led to research on its use for bone regeneration applications. Numerous studies in animal models have indicated enhanced fracture healing as a result of once daily injections of PTH. ...This review briefly summarizes the unmet clinical need for improved bone regeneration techniques and how PTH may help fill that void by both systemically and locally delivered PTH for bone regeneration applications. © 2018 Orthopaedic Research Society. ...
The anabolic effect PTH has on bone has led to research on its use for bone regeneration applications. Numerous studies …
Nanostructured Surface Modification to Bone Implants for Bone Regeneration.
Wang Q, et al. J Biomed Nanotechnol 2018 - Review. PMID 31352938
Bone defect repair is a complex process of bone regeneration. Bone substitute implanted at the bone defect sites act as three-dimensional scaffolds that guide and promote bone regeneration. ...Biological behaviors of immune cells and osteogenesis-related cells on these bone biomaterials are largely determined by the surface properties. ...
Bone defect repair is a complex process of bone regeneration. Bone substitute implanted at the bone defec
Demineralized bone matrix and calcium-phosphate cement in bone regeneration in rats.
Silva LCFD, et al. Acta Cir Bras 2018. PMID 29768538 Free article.
PURPOSE: To compare bone regeneration in critical-sized defects in rat calvarium using demineralized bone matrix and calcium phosphate cement. ...CONCLUSIONS: The demineralized bone matrix was superior to calcium phosphate cement in bone regeneration. It seems that calcium phosphate cement acted by inhibiting the osteogenesis when associated with a demineralized bone matrix and this combination should not be recommended....
PURPOSE: To compare bone regeneration in critical-sized defects in rat calvarium using demineralized bone matrix and ca …
Fracture healing: mechanisms and interventions
Einhorn TA and Gerstenfeld LC. Nat Rev Rheumatol 2015 - Review. PMID 25266456 Free PMC article.
The repair of bone fractures is a postnatal regenerative process that recapitulates many of the ontological events of embryonic skeletal development. ...The biophysical and biological basis of the molecular actions of various therapeutic approaches, including recombinant human bone morphogenetic proteins and parathyroid hormone therapy, are also discussed....
The repair of bone fractures is a postnatal regenerative process that recapitulates many of the ontological events of embryoni …
Limitations and options using resorbable versus nonresorbable membranes for successful guided bone regeneration.
Soldatos NK, et al. Quintessence Int 2017 - Review. PMID 27834419
Several treatment modalities are used to regenerate bone, including guided bone regeneration (GBR). The purpose of this study was to summarize the knowledge on different types of membranes available and currently used in GBR procedures in a staged approach or with simultaneous implant placement. ...For vertical bone augmentation procedures, the most appropriate membranes are the nonresorbable. For combination defects, both types result in a successful outcome....
Several treatment modalities are used to regenerate bone, including guided bone regeneration (GBR). The purpose of this …
BMPs in bone regeneration: Less is more effective, a paradigm-shift.
Schmidt-Bleek K, et al. Cytokine Growth Factor Rev 2016 - Review. PMID 26678813
Worldwide, the clinical application of BMP2 (bone morphogenetic protein 2) has helped an increasing number of patients achieve bone regeneration in a clinical area lacking simple solutions for difficult bone healing situations. ...Knowledge concerning how the dose of this growth factor as well as its interaction with mechanical loading influences the efficacy of bone regeneration, might open possible future strategies in cases where bony bridging is unachievable so far. ...
Worldwide, the clinical application of BMP2 (bone morphogenetic protein 2) has helped an increasing number of patients achieve bon
Platelet concentrates for bone regeneration: Current evidence and future challenges.
Badran Z, et al. Platelets 2018 - Review. PMID 28649897
Platelet concentrates are commonly used for bone regeneration purposes based on the fact that growth factors released from activated platelets alpha granules have osteoinductive effects on bone cells. Although most preclinical and clinical studies show that platelet concentrates improve the outcomes of bone regeneration procedures, some studies reported conflicting results and even negative effects on bone healing. ...
Platelet concentrates are commonly used for bone regeneration purposes based on the fact that growth factors released from act …
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