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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1949 1
1960 1
1961 1
1963 2
1964 2
1987 1
1991 2
1992 2
1993 6
1994 51
1995 76
1996 101
1997 127
1998 160
1999 222
2000 234
2001 251
2002 296
2003 341
2004 426
2005 549
2006 495
2007 534
2008 628
2009 613
2010 634
2011 664
2012 680
2013 691
2014 636
2015 661
2016 512
2017 485
2018 416
2019 184
2020 7
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9,369 results
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Page 1
Unfocused shockwaves for osteoinduction in bone substitutes in rat cortical bone defects.
Koolen MKE, et al. PLoS One 2018. PMID 29969479 Free PMC article.
Bone substitutes are frequently used in clinical practice but often exhibit limited osteoinductivity. We hypothesized that unfocused shockwaves enhance the osteoinductivity of bone substitutes and improve osteointegration and angiogenesis. ...The net volume of de novo bone in the defect was measured by microCT-scanning during 11-weeks follow-up. Bone ingrowth and angiogenesis in the bone substitutes was examined at 5 and 11 weeks using histology. ...
Bone substitutes are frequently used in clinical practice but often exhibit limited osteoinductivity. We hypothesized that unf
Comparison of three block bone substitutes for bone regeneration: long-term observation in the beagle dog.
Sawada K, et al. Odontology 2018. PMID 29557992
This study aimed to evaluate the impact of three types of block bone substitute material on bone formation and graft resorption in vivo. ...However, the positive impact of all biomaterials on new bone formation and replacement of bone was minor even at 12 months. These findings indicate that block bone substitutes are not well suited to vertical bone augmentation. ...
This study aimed to evaluate the impact of three types of block bone substitute material on bone formation and graft re …
Biopolymers as bone substitutes: a review.
Kashirina A, et al. Biomater Sci 2019 - Review. PMID 31364613
The main goal of this paper was to summarize the recent research on polymer materials as bone substitutes and for bone repair. Bone treatment methods, bone substitute materials as well as their advantages and drawbacks, and manufacturing methods were reviewed. ...
The main goal of this paper was to summarize the recent research on polymer materials as bone substitutes and for bone
Advances in osteobiologic materials for bone substitutes.
Hasan A, et al. J Tissue Eng Regen Med 2018 - Review. PMID 29701908
A significant challenge in the current orthopedics is the development of suitable osteobiologic materials that can replace the conventional allografts, autografts, and xenografts and thereby serve as implant materials as bone substitutes for bone repair or remodelling. ...This review presents an overview of various types of osteobiologic materials to facilitate the formation of the functional bone tissue and healing of the bone, covering metallic, ceramic, polymeric, and cell-based graft substitutes, as well as some biomolecular strategies including stem cells, extracellular matrices, growth factors, and gene therapies. ...
A significant challenge in the current orthopedics is the development of suitable osteobiologic materials that can replace the conventional …
Bone Graft Substitutes in Single- or Double-Level Anterior Cervical Discectomy and Fusion: A Systematic Review.
Stark JR, et al. Spine (Phila Pa 1976) 2019. PMID 30395088
Today bone graft substitutes including ceramic-based synthetic bone grafts, allografts, bone morphogenetic proteins (BMPs), mesenchymal stem cells, and bone marrow aspirate are widely used to enhance fusions; even though the efficacy of these substitutes is poorly defined. ...Physicians should consider this when choosing to use bone graft substitutes for routine ACDFs. LEVEL OF EVIDENCE: 4....
Today bone graft substitutes including ceramic-based synthetic bone grafts, allografts, bone morphogenetic prote …
Facial Bone Reconstruction Using both Marine or Non-Marine Bone Substitutes: Evaluation of Current Outcomes in a Systematic Literature Review.
Cicciù M, et al. Mar Drugs 2018 - Review. PMID 29342834 Free PMC article.
Clinical trials and animal in vitro studies that had reported the application of bone substitutes or not for bone reconstruction defect and using marine collagen or other bone substitute material were recorded following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. ...All selected manuscripts considered the final clinical success after the facial bone reconstruction applying bone substitutes. ...
Clinical trials and animal in vitro studies that had reported the application of bone substitutes or not for bone recon …
Human Studies of Vertical and Horizontal Alveolar Ridge Augmentation Comparing Different Types of Bone Graft Materials: A Systematic Review.
Chavda S and Levin L. J Oral Implantol 2018 - Review. PMID 29135351
Currently, autogenous bone is labeled as the "gold standard" because of faster healing times and integration between native and foreign bone. ...There were no discernible differences in implant success between bone augmentation materials. Generally, patients preferred nonautogenous bone sources as there were fewer hospital days, less pain, and better recovery time. ...
Currently, autogenous bone is labeled as the "gold standard" because of faster healing times and integration between native and forei …
Multinucleated Giant Cells: Good Guys or Bad Guys?
Miron RJ and Bosshardt DD. Tissue Eng Part B Rev 2018 - Review. PMID 28825357
More recently, however, a special subclass of bone biomaterials has been found bordered by large MNGCs virtually incapable of resorbing bone substitutes even years after their implantation yet surrounded by stable bone. ...In summary, four central aspects of this review are discussed with a focus on (1) the role of MNGCs in bone/tissue biology, and their ability to induce vascularization/new bone formation, their role around, (2) bone substitutes for bone augmentation, (3) dental implants, as well as (4) during peri-implant infection. ...
More recently, however, a special subclass of bone biomaterials has been found bordered by large MNGCs virtually incapable of resorbi …
Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration.
Perić Kačarević Z, et al. Int J Artif Organs 2018. PMID 29707988
Xenogeneic bone substitute materials are widely used in oral implantology. Prior to their clinical use, purification of the former bone tissue has to be conducted to ensure the removal of immunogenic components and pathogens. ...Thus, the aim of this mini-review is to summarize the preparation processes and the related material characteristics, safety aspects, tissue reactions, resorbability and preclinical and clinical data of two widely used xenogeneic bone substitutes that mainly differ in the temperature treatment: sintered (cerabone(®)) and non-sintered (Bio-Oss(®)) bovine-bone materials. ...
Xenogeneic bone substitute materials are widely used in oral implantology. Prior to their clinical use, purification of the fo …
Promoting osteoblast proliferation on polymer bone substitutes with bone-like structure by combining hydroxyapatite and bioactive glass.
Zhao B, et al. Mater Sci Eng C Mater Biol Appl 2019. PMID 30606514
However, to trigger effective bone formation and implant integration, the bioactivity of bone substitutes plays a vital role. ...These results suggest that the BG/HA/PE composites having a bone-like structure have high potential as bone substitutes to repair large bone defects....
However, to trigger effective bone formation and implant integration, the bioactivity of bone substitutes plays a vital …
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