Severe Hypoglycemia Caused by a Giant Borderline Phyllodes Tumor of the Breast: A Case Report and Literature Review

Yaoxia Liu; Min Zhang; Xudan Yang; Min Zhang; Zhen Fan; Yi Li; Tao Wang; Ping Chen

doi:10.3389/fendo.2022.871998

Severe Hypoglycemia Caused by a Giant Borderline Phyllodes Tumor of the Breast: A Case Report and Literature Review

Front Endocrinol (Lausanne). 2022 May 26:13:871998. doi: 10.3389/fendo.2022.871998. eCollection 2022.

Authors

Yaoxia Liu^{1

2}, Min Zhang^{1

2}, Xudan Yang^{2

3}, Min Zhang^{1

2}, Zhen Fan^{1

2}, Yi Li^{2

4}, Tao Wang^{5

6

7}, Ping Chen^{1

2}

Affiliations

¹ Department of Geriatrics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
² Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China.
³ Department of Pathology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
⁴ Mastology Department, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
⁵ Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
⁶ Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
⁷ The Cardiac Development and Early Intervention Unit, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, China.

Abstract

A case of hypoglycemic coma caused by a giant borderline phyllodes tumor of the breast has been described. The patient, a 63-year-old woman, was admitted with recurrent unconsciousness. She had a giant breast tumor with decreased blood glucose, insulin, and C-peptide. The patient's hypoglycemia resolved rapidly after resection of the breast tumor. Pathological examination indicated a borderline phyllodes tumor of the breast, and immunohistochemistry suggested high expression of insulin-like growth factor-2 (IGF-2) in the tumor tissue. A literature review is also included to summarize the clinical characteristics of such patients and to serve as a unique resource for clinical diagnosis and treatment of similar cases.

Keywords: breast; hypoglycemia; insulin-like growth factor-2; non-islet cell tumor hypoglycemia; phyllodes tumor.

Publication types

Case Reports
Systematic Review
Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms* / complications
Breast Neoplasms* / metabolism
Breast Neoplasms* / surgery
C-Peptide
Female
Humans
Hypoglycemia* / etiology
Insulin
Middle Aged
Phyllodes Tumor* / complications
Phyllodes Tumor* / metabolism
Phyllodes Tumor* / surgery

Substances

C-Peptide
Insulin