Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 4
1997 18
1998 48
1999 79
2000 165
2001 210
2002 230
2003 258
2004 256
2005 261
2006 157
2007 40
2008 42
2009 63
2010 73
2011 81
2012 87
2013 68
2014 79
2015 91
2016 73
2017 61
2018 68
2019 28
2020 2
Text availability
Article attribute
Article type
Publication date

Search Results

2,362 results
Results by year
Filters applied: . Clear all
Page 1
Integrated genomic and molecular characterization of cervical cancer
Cancer Genome Atlas Research Network , et al. Nature 2017. PMID 28112728 Free PMC article.
We observed notable APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2 as novel significantly mutated genes in cervical cancer. ...Integration of human papilloma virus (HPV) was observed in all HPV18-related samples and 76% of HPV16-related samples, and was associated with structural aberrations and increased target-gene expression. ...
We observed notable APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2 as novel significantly mutated …
Proteome-wide covalent ligand discovery in native biological systems
Backus KM, et al. Nature 2016. PMID 27309814 Free PMC article.
Small molecules are powerful tools for investigating protein function and can serve as leads for new therapeutics. Most human proteins, however, lack small-molecule ligands, and entire protein classes are considered 'undruggable'. ...We used these ligands to distinguish extrinsic apoptosis pathways in human cell lines versus primary human T cells, showing that the former is largely mediated by caspase-8 while the latter depends on both caspase-8 and -10. ...
Small molecules are powerful tools for investigating protein function and can serve as leads for new therapeutics. Most human
Necroptosis and Inflammation
Newton K and Manning G. Annu Rev Biochem 2016 - Review. PMID 26865533
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation
Zhang CJ, et al. J Clin Invest 2018. PMID 30372424 Free PMC article.
Microglia-specific deficiency of ASC (apoptosis-associated speck-like protein containing a C-terminal caspase-activation and recruitment [CARD] domain) attenuated T cell expansion and neutrophil recruitment during EAE pathogenesis. ...
Microglia-specific deficiency of ASC (apoptosis-associated speck-like protein containing a C-terminal caspase-activation and recruitm …
Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death
Garcia-Carbonell R, et al. Proc Natl Acad Sci U S A 2018. PMID 30209212 Free PMC article.
This effect was dependent on Receptor Interacting Protein Kinase 1 (RIPK1) activity, and A20 was found to associate with the Ripoptosome complex, potentiating its ability to activate caspase-8. ...
This effect was dependent on Receptor Interacting Protein Kinase 1 (RIPK1) activity, and A20 was found to associate with the Ripoptos …
RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation
Liccardi G, et al. Mol Cell 2019. PMID 30598363 Free PMC article.
Receptor-interacting protein kinase (RIPK) 1 functions as a key mediator of tissue homeostasis via formation of Caspase-8 activating ripoptosome complexes, positively and negatively regulating apoptosis, necroptosis, and inflammation. ...
Receptor-interacting protein kinase (RIPK) 1 functions as a key mediator of tissue homeostasis via formation of Caspase-8 activating …
RIP3 induces apoptosis independent of pronecrotic kinase activity
Mandal P, et al. Mol Cell 2014. PMID 25459880 Free PMC article.
Receptor-interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to control inflammatory disease. ...These compounds interact with RIP3 to activate caspase 8 (Casp8) via RHIM-driven recruitment of RIP1 (RIPK1) to assemble a Casp8-FADD-cFLIP complex completely independent of pronecrotic kinase activities and MLKL. ...
Receptor-interacting protein kinase 3 (RIP3 or RIPK3) has emerged as a central player in necroptosis and a potential target to contro …
Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing
Sanchez-Garrido J, et al. Sci Signal 2018. PMID 30514811 Free article.
The multidomain scaffold protein p62 (also called sequestosome-1) is involved in autophagy, antimicrobial immunity, and oncogenesis. ...Here, we report that p62 was proteolytically trimmed by the protease caspase-8 into a stable protein, which we called p62(TRM) We found that p62(TRM), but not full-length p62, was involved in nutrient sensing and homeostasis through the mechanistic target of rapamycin complex 1 (mTORC1). ...
The multidomain scaffold protein p62 (also called sequestosome-1) is involved in autophagy, antimicrobial immunity, and oncogenesis. …
2,362 results
Jump to page
Feedback