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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 3
1998 4
1999 6
2000 6
2001 24
2002 30
2003 30
2004 37
2005 31
2006 27
2007 21
2008 28
2009 16
2010 20
2011 19
2012 17
2013 19
2014 36
2015 25
2016 24
2017 36
2018 23
2019 12
2020 0
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445 results
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Page 1
CCL17 blockade as a therapy for osteoarthritis pain and disease.
Lee MC, et al. Arthritis Res Ther 2018. PMID 29622035 Free PMC article.
METHODS: CiOA was induced in C57BL/6 wild-type (WT), Irf4 (-/-) , Ccl17 (E/E) , Ccr4 (-/-) , Tnf (-/-) and GM-CSF (-/-) mice. ...RESULTS: Studies in the gene-deficient mice indicated that IRF4, CCL17 and the CCL17 receptor, CCR4, but not TNF, were required for CiOA pain and optimal cartilage destruction and osteophyte size. ...
METHODS: CiOA was induced in C57BL/6 wild-type (WT), Irf4 (-/-) , Ccl17 (E/E) , Ccr4 (-/-) , Tnf (-/-) and GM-CSF (-/-) mice. ...RESU …
Dupilumab treatment in adults with moderate-to-severe atopic dermatitis
Beck LA, et al. N Engl J Med 2014 - Clinical Trial. PMID 25006719 Free article.
BACKGROUND: Dupilumab, a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, has shown efficacy in patients with asthma and elevated eosinophil levels. ...
BACKGROUND: Dupilumab, a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, has shown efficacy in patients …
Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages.
Tarique AA, et al. Am J Respir Cell Mol Biol 2015. PMID 25870903 Free article.
In addition, the persistence and reversibility of polarized human phenotypes is not well established. Human peripheral blood monocytes were differentiated into uncommitted macrophages (M0) and then polarized to M1 and M2 phenotypes using LPS/IFN-γ and IL-4/IL-13, respectively. ...Polarized M1 cells secreted IP-10, IFN-γ, IL-8, TNF-α, IL-1β, and RANTES, whereas M2 cells secreted IL-13, CCL17, and CCL18. ...
In addition, the persistence and reversibility of polarized human phenotypes is not well established. Human peripheral blood m …
Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation.
Achuthan A, et al. J Clin Invest 2016. PMID 27525438 Free PMC article.
In this work, we provide evidence that GM-CSF drives CCL17 production by acting through an IFN regulatory factor 4-dependent (IRF4-dependent) pathway in human monocytes, murine macrophages, and mice in vivo. In murine models of arthritis and pain, IRF4 regulated the formation of CCL17, which mediated the proinflammatory and algesic actions of GM-CSF. ...
In this work, we provide evidence that GM-CSF drives CCL17 production by acting through an IFN regulatory factor 4-dependent (IRF4-de …
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer
Berlato C, et al. J Clin Invest 2017. PMID 28134623 Free PMC article.
Here, we have determined that CCR4 was highly expressed in human renal cell carcinoma (RCC) biopsies and observed abnormal levels of CCR4 ligands in RCC patient plasma. ...Moreover, CCL17-induced IFN-γ production was reduced when Th1-polarized normal CD4+ T cells were exposed to the CCR4 ligand, evidencing the involvement of CCR4 in Th1/Th2 regulation. ...
Here, we have determined that CCR4 was highly expressed in human renal cell carcinoma (RCC) biopsies and observed abnormal levels of …
CCL17/thymus and activation-regulated chemokine induces calcitonin gene-related peptide in human airway epithelial cells through CCR4.
Bonner K, et al. J Allergy Clin Immunol 2013. PMID 23731651
OBJECTIVE: We sought to determine whether CCL17 induces CCR4-dependent CGRP synthesis and secretion by human airway epithelial cells. METHODS: Human airway epithelial cell lines (BEAS-2B and A549) and human primary airway cells were cultured with CCL17 or various other cytokines, and CGRP expression was measured by using RT-PCR, quantitative immunofluorescence, and enzyme immunoassay. ...
OBJECTIVE: We sought to determine whether CCL17 induces CCR4-dependent CGRP synthesis and secretion by human airway epithelial …
Efficacy and safety of ustekinumab treatment in adults with moderate-to-severe atopic dermatitis
Khattri S, et al. Exp Dermatol 2017 - Clinical Trial. PMID 27304428 Free PMC article.
Study endpoints included clinical (SCORAD50) and biopsy-based measures of tissue structure and inflammation, using protein and gene expression studies. ...MMP12, IL-22, IL-13, IFN-γ, elafin/PI3, CXCL1 and CCL17; P<.05). Epidermal responses (K16, terminal differentiation) showed faster (4 weeks) and long-term regulation (32 weeks) from baseline in the ustekinumab group. ...
Study endpoints included clinical (SCORAD50) and biopsy-based measures of tissue structure and inflammation, using protein and gene e …
Decreased expression of CCL17 in the disrupted nasal polyp epithelium and its regulation by IL-4 and IL-5.
Kim B, et al. PLoS One 2018. PMID 29746583 Free PMC article.
In addition, the expression level of CCL17 was determined in cultured epithelial cells treated with IL-4, IL-5, IL-13, TNF-α, and IFN-γ. ...Interestingly, the stimulation of cultured epithelial cells with Th2 cytokines, IL-4 and IL-5, resulted in an upregulation of CCL17 expression only in NP epithelial cells whereas the expression of CCL17 was increased in both normal epithelial cells and NP epithelial cells by Th1 cytokines. ...
In addition, the expression level of CCL17 was determined in cultured epithelial cells treated with IL-4, IL-5, IL-13, TNF-α, and IFN …
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