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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 8
1992 39
1993 30
1994 36
1995 18
1996 25
1997 27
1998 27
1999 38
2000 45
2001 22
2002 38
2003 35
2004 26
2005 28
2006 38
2007 41
2008 31
2009 30
2010 41
2011 46
2012 30
2013 32
2014 42
2015 33
2016 29
2017 19
2018 33
2019 8
2020 0
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828 results
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Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy.
Fumet JD, et al. Br J Cancer 2018. PMID 30318514 Free PMC article.
BACKGROUND: No study has evaluated the predictive and prognostic role of CD8 and PD-L1 coexpression in non-small-cell lung cancer (NSCLC). ...In predictive cohort, high CD8 expression and CD8A mRNA were associated with longer progression-free survival (PFS) (p = 0.0002). ...
BACKGROUND: No study has evaluated the predictive and prognostic role of CD8 and PD-L1 coexpression in non-small-cell lung cancer (NS …
A Synthetic CD8α:MyD88 Coreceptor Enhances CD8(+) T-cell Responses to Weakly Immunogenic and Lowly Expressed Tumor Antigens.
Kaczanowska S, et al. Cancer Res 2017. PMID 29055013 Free PMC article.
Here, we developed a fusion protein by linking CD8α and MyD88 (CD8α:MyD88) to enhance CD8(+) T-cell responses to weakly immunogenic and poorly expressed tumor antigens. CD8α:MyD88-engineered T cells exhibited increased proliferation and expression of effector and costimulatory molecules in a tumor antigen-dependent manner. ...
Here, we developed a fusion protein by linking CD8α and MyD88 (CD8α:MyD88) to enhance CD8(+) T-cell responses to weakly immunogenic a …
Regeneration of CD8αβ T Cells from T-cell-Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity.
Maeda T, et al. Cancer Res 2016. PMID 27872100 Free article.
Here we report that, by stimulating purified iPSC-derived CD4/CD8 double-positive cells with anti-CD3 antibody, T cells expressing CD8αβ were generated and exhibited improved antigen-specific cytotoxicity compared with CD8αα(+) CTL. ...We found that WT1 tumor antigen-specific CTL regenerated by this method prolonged the survival of mice bearing WT1-expressing leukemic cells. ...
Here we report that, by stimulating purified iPSC-derived CD4/CD8 double-positive cells with anti-CD3 antibody, T cells expressing CD …
Negligible Role for Deletion Mediated by cDC1 in CD8(+) T Cell Tolerance.
MacNabb BW, et al. J Immunol 2019. PMID 30902900 Free PMC article.
Deletion of CD8(+) T cells by dendritic cells (DCs) is recognized as a critical mechanism of immune tolerance to self-antigens. ...However, endogenous CD8(+) T cells from the periphery of Batf3(-/-) mice do not exhibit heightened self-reactivity, and deep TCR sequencing of CD8(+) T cells from Batf3(-/-) and Batf3(+/+) mice reveals that cDC1 have a minimal impact on shaping the peripheral CD8(+) T cell repertoire. ...
Deletion of CD8(+) T cells by dendritic cells (DCs) is recognized as a critical mechanism of immune tolerance to self-antigens
Diversity of two Theileria parva CD8+ antigens in cattle and buffalo-derived parasites in Tanzania.
Kerario II, et al. Ticks Tick Borne Dis 2019. PMID 31151920
This study was conducted to assess genetic diversity of Tp1 and Tp2 genes from T. parva isolates that are recognized by CD8 + T-cells in cattle and buffalo. ...The study also revealed that most samples from the seven populations possessed several epitopes in antigens that were identical to those in the T. parva Muguga reference stock, which is the main component of the widely used live vaccine cocktail. ...
This study was conducted to assess genetic diversity of Tp1 and Tp2 genes from T. parva isolates that are recognized by CD8 + T-cells …
Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 signalling in head and neck squamous cell carcinoma
Ma H, et al. Br J Cancer 2019. PMID 30555157 Free PMC article.
METHODS: We examine the expression of interferon alpha/beta receptor-1 (IFNAR1), CD8, CD56 and programmed death ligand 1 (PDL1) in head and neck squamous cell carcinomas (HNSCC). ...
METHODS: We examine the expression of interferon alpha/beta receptor-1 (IFNAR1), CD8, CD56 and programmed death ligand 1 (PDL1) in he …
Essential Roles of SATB1 in Specifying T Lymphocyte Subsets
Kakugawa K, et al. Cell Rep 2017. PMID 28494867 Free article.
Here, we show that, in post-selection thymocytes, a genome organizer, SATB1, activates genes for lineage-specifying factors, including ThPOK, Runx3, CD4, CD8, and Treg factor Foxp3, via regulating enhancers in these genes in a locus-specific manner. ...
Here, we show that, in post-selection thymocytes, a genome organizer, SATB1, activates genes for lineage-specifying factors, including ThPOK …
Innate CD8αα+ lymphocytes enhance anti-CD40 antibody-mediated colitis in mice
Kumar AA, et al. Immun Inflamm Dis 2017. PMID 28474503 Free PMC article.
We also observed that the pro-inflammatory properties of iCD8α cells were controlled by interactions of CD8αα homodimers on these cells with the thymus leukemia antigen expressed by intestinal epithelial cells. ...
We also observed that the pro-inflammatory properties of iCD8α cells were controlled by interactions of CD8αα homodimers on these cells with …
Classification of tumor microenvironment immune types based on immune response-associated gene expression
Kondou R, et al. Int J Oncol 2019. PMID 30387832
Type A, with PD‑L1+ and CD8B+, exhibited an upregulation of cytotoxic T lymphocyte (CTL) killing‑associated genes, T‑cell activation genes, antigen‑presentation and dendritic cell (DC) maturation genes, and T‑cell‑attracting chemokine genes, which promoted Th1 antitumor responses. ...
Type A, with PD‑L1+ and CD8B+, exhibited an upregulation of cytotoxic T lymphocyte (CTL) killing‑associated genes, T‑cell activation genes, …
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