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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1990 2
1991 58
1992 145
1993 178
1994 154
1995 45
1996 89
1997 64
1998 59
1999 82
2000 73
2001 65
2002 52
2003 67
2004 75
2005 70
2006 81
2007 79
2008 74
2009 51
2010 59
2011 78
2012 55
2013 46
2014 57
2015 40
2016 38
2017 28
2018 34
2019 15
2020 0
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1,927 results
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Page 1
Cancer vaccines
Butterfield LH. BMJ 2015 - Review. PMID 25904595 Free PMC article.
Cancer vaccines are designed to promote tumor specific immune responses, particularly cytotoxic CD8 positive T cells that are specific to tumor antigens. ...Technological developments in the past few years have enabled the investigation of vaccines that target mutated antigens that are patient specific. ...
Cancer vaccines are designed to promote tumor specific immune responses, particularly cytotoxic CD8 positive T cells that are specifi …
TCRαβ(+)CD3(+)CD4(-)CD8(-) (double negative) T cells in autoimmunity.
Brandt D and Hedrich CM. Autoimmun Rev 2018 - Review. PMID 29428806
TCRαβ(+)CD3(+)CD4(-)CD8(-) "double negative" (DN) T cells comprise a small subset of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and discussed controversially. ...
TCRαβ(+)CD3(+)CD4(-)CD8(-) "double negative" (DN) T cells comprise a small subset of mature peripheral T cells. The origin and functi …
Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy
Minagawa A, et al. Cell Stem Cell 2018. PMID 30449714 Free article.
Here, we report that CD8αβ T cells from human T-iPSCs lose their antigen specificity through additional rearrangement of the T cell receptor (TCR) α chain gene during the CD4/CD8 double positive stage of in vitro differentiation. ...
Here, we report that CD8αβ T cells from human T-iPSCs lose their antigen specificity through additional rearrangement of the T cell receptor …
TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4(+)CD8(+) thymocytes.
Emmanuel AO, et al. Nat Immunol 2018. PMID 30420627 Free PMC article.
Ablating either TCF-1 or HEB in CD4(+)CD8(+) thymocytes elicits similar developmental outcomes including increased proliferation, decreased survival, and fewer late Tcra rearrangements. ...Thus, TCF-1 shifts nucleosomes and safeguards HEB, thereby enabling their cooperation in establishing the epigenetic and transcription profiles of CD4(+)CD8(+) thymocytes....
Ablating either TCF-1 or HEB in CD4(+)CD8(+) thymocytes elicits similar developmental outcomes including increased proliferation, dec …
Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8(+) T Cells.
Yamada T, et al. J Immunol 2019. PMID 30626691
However, Utx deficiency resulted in more Ag-specific CD8(+) T cells upon secondary infection. Adoptive transfer of Utx KO CD8(+) T cells resulted in a larger number of memory cells in the primary response than in WT. ...The treatment of CD8(+) T cells with Utx-cofactor α-ketoglutarate hampered the memory formation, whereas Utx inhibitor GSK-J4 enhanced the memory formation in WT CD8(+) T cells. ...
However, Utx deficiency resulted in more Ag-specific CD8(+) T cells upon secondary infection. Adoptive transfer of Utx KO CD8( …
CD4+ CD8+ double positive (DP) T cells in health and disease.
Parel Y and Chizzolini C. Autoimmun Rev 2004 - Review. PMID 15110234
However, double positive (DP) T cells expressing both CD4 and CD8 have been described in several pathological conditions as well as in normal individuals. ...Strong evidence indicates that in vivo terminally differentiated effector CD4 may acquire the alpha-chain of CD8. Reciprocally, in vitro activation of CD8+ T cells results in the expression of low levels of CD4 that may mediate HIV entry and responses to chemotactic cytokines. ...
However, double positive (DP) T cells expressing both CD4 and CD8 have been described in several pathological conditions as well as i …
Generation of Antigen-Specific T Cells from Human Induced Pluripotent Stem Cells
Nishimura T and Nakauchi H. Methods Mol Biol 2019. PMID 30649763
Here, we show the in vitro way to guide T-iPSCs sequentially to yield hematopoietic stem/progenitor cells (HSPCs), T-lineage cells, and mature CD8 single-positive T cells. These in vitro-generated CD8(+) T cells display antigen-specific cytotoxity and perform general T-cell functions. This novel protocol thus provides means to generate antigen-specific T cells as well as chances to study normal human lymphopoiesis. ...
Here, we show the in vitro way to guide T-iPSCs sequentially to yield hematopoietic stem/progenitor cells (HSPCs), T-lineage cells, and matu …
Correlation of cell-surface CD8 levels with function, phenotype and transcriptome of naive CD8 T cells.
Balyan R, et al. Immunology 2019. PMID 30556901 Free PMC article.
We report that, when either polyclonal and T-cell receptor (TCR)-transgenic monoclonal peripheral naive CD8 T cells from young mice were separated into CD8(hi) and CD8(lo) subsets, CD8(lo) cells responded poorly, but CD8(hi) and CD8(lo) subsets of CD8 single-positive (SP) thymocytes responded similarly. ...Bulk mRNA sequencing showed major differences in the transcriptional landscapes of CD8(hi) and CD8(lo) naive CD8 T cells. CD8(hi) naive CD8 T cells showed enrichment of genes involved in positive regulation of cell cycle and survival. ...
We report that, when either polyclonal and T-cell receptor (TCR)-transgenic monoclonal peripheral naive CD8 T cells from young mice w …
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