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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 1
1991 28
1992 84
1993 101
1994 117
1995 73
1996 76
1997 66
1998 63
1999 100
2000 106
2001 113
2002 113
2003 151
2004 112
2005 117
2006 110
2007 90
2008 98
2009 112
2010 128
2011 128
2012 106
2013 106
2014 108
2015 74
2016 83
2017 76
2018 67
2019 32
2020 1
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2,562 results
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Page 1
Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis
Savas P, et al. Nat Med 2018. PMID 29942092
We demonstrate that BCs with a high number of TILs contained CD8(+) T cells with features of tissue-resident memory T (T(RM)) cell differentiation and that these CD8(+) T(RM) cells expressed high levels of immune checkpoint molecules and effector proteins. A CD8(+) T(RM) gene signature developed from the scRNA-seq data was significantly associated with improved patient survival in early-stage triple-negative breast cancer (TNBC) and provided better prognostication than CD8 expression alone. ...
We demonstrate that BCs with a high number of TILs contained CD8(+) T cells with features of tissue-resident memory T (T(RM)) cell di …
New Insights Into the Biology of CD8 Regulatory T Cells.
Nakagawa H, et al. Adv Immunol 2018 - Review. PMID 30366517
Disruption of CD8 Treg-dependent recognition of Qa-1-restricted self-antigens can result in dysregulated immune responses, tissue damage, autoimmune disease and cancer. ...Recent analyses of T-cell receptor usage and antigen recognition by Qa-1-restricted CD8 Treg have provided additional insight into the unusual biological function of this regulatory CD8 lineage. ...
Disruption of CD8 Treg-dependent recognition of Qa-1-restricted self-antigens can result in dysregulated immune responses, tis …
Roles of regulatory T cells in cancer immunity
Takeuchi Y and Nishikawa H. Int Immunol 2016 - Review. PMID 27160722 Free PMC article.
Additionally, increased numbers of Tregs and, in particular, decreased ratios of CD8(+) T cells to Tregs among tumor-infiltrating lymphocytes are correlated with poor prognosis in various types of human cancers. ...
Additionally, increased numbers of Tregs and, in particular, decreased ratios of CD8(+) T cells to Tregs among tumor-infiltrating lym …
Multispectral Imaging of T and B Cells in Murine Spleen and Tumor
Feng Z, et al. J Immunol 2016. PMID 26994219 Free PMC article.
We compared different fixation protocols and Ag-retrieval techniques and validated the use of multiplex immunohistochemistry for detection of CD3(+)CD4(+) and CD3(+)CD8(+) T cell subsets in murine spleen and tumor. ...
We compared different fixation protocols and Ag-retrieval techniques and validated the use of multiplex immunohistochemistry for detection o …
G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment.
Sumida H and Cyster JG. Front Immunol 2018. PMID 29670628 Free PMC article.
When the receptor is lacking, mice develop fewer CD8(+) KLRG1(+) Granzyme B(+) effector-memory cells. Bone marrow chimera studies show that the GPR18 requirement is CD8 T cell intrinsic. GPR18 is not required for T-bet expression in KLRG1(+) CD8 T cells. Gene transduction experiments confirm the functional activity of GPR18 in CD8 T cells. ...
When the receptor is lacking, mice develop fewer CD8(+) KLRG1(+) Granzyme B(+) effector-memory cells. Bone marrow chimera studies sho …
Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients
Kirilovsky A, et al. Int Immunol 2016 - Review. PMID 27121213 Free PMC article.
In colorectal cancer, we have developed a prognostic score ('Immunoscore') that takes into account the distribution of the density of both CD3(+) lymphocytes and CD8(+) cytotoxic T cells in the tumor core and the invasive margin that could outperform TNM staging. ...
In colorectal cancer, we have developed a prognostic score ('Immunoscore') that takes into account the distribution of the density of both C …
Isolation and Functional Use of Human NKT Cells
Exley MA, et al. Curr Protoc Immunol 2017. PMID 29091262
The term 'iNKT' derives from the fact that a large fraction of murine and some human NK marker+ T cells ('NKT') recognize the MHC class I-like CD1d protein and use an identical 'invariant' TCRα chain, which is generated in humans by precise Vα24 and Jα18 rearrangements with either no N-region diversity or subsequent trimming to identical or nearly identical amino acid sequence (hence, 'iNKT' cells). iNKT are mostly CD4+ or CD4-CD8- ('double negative'), although a few CD8+ iNKT can be found in some humans. ...
The term 'iNKT' derives from the fact that a large fraction of murine and some human NK marker+ T cells ('NKT') recognize the MHC class I-li …
CD8 signaling in microglia/macrophage M1 polarization in a rat model of cerebral ischemia.
Boddaert J, et al. PLoS One 2018. PMID 29342151 Free PMC article.
Comparing key receptors involved in M1 polarization (CD8, IFNγR, Clec4, FcγR, TLR3 and TLR4) and their signal transducers (Syk, Stat1, Irf3, and Traf6) at the day 4 time point, we showed a strong upregulation of CD8 along with SYK transducer in dissected perilesional brain tissue. ...In vitro ligand-based stimulation of the CD8 receptor caused increased iNOS expression and an enhanced capacity to phagocytose E. coli particles; and interestingly, CD8 stimulation was also able to repolarize IL4-treated M2 cells to an M1 phenotype. ...
Comparing key receptors involved in M1 polarization (CD8, IFNγR, Clec4, FcγR, TLR3 and TLR4) and their signal transducers (Syk, Stat1 …
CD8(dim) but not CD8(bright) cells positive to CD56 dominantly express KIR and are cytotoxic during visceral leishmaniasis.
Kumari S, et al. Hum Immunol 2018. PMID 29842895
These cells were recognized as CD8(dim)CD56(+)NKT and CD8(bright)CD56(+)NKT cells. We further analyzed the functional nature of CD8(dim) and CD8(bright) positive CD56(+)NKT cells. ...This study concludes that CD8(dim)CD56(+)NKT cells are more cytotoxic than CD8(bright)CD56(+)NKT cells during VL....
These cells were recognized as CD8(dim)CD56(+)NKT and CD8(bright)CD56(+)NKT cells. We further analyzed the functional nature o …
2,562 results
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