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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 6
2001 5
2002 8
2003 4
2004 11
2005 11
2006 20
2007 20
2008 29
2009 21
2010 24
2011 39
2012 15
2013 21
2014 28
2015 18
2016 18
2017 13
2018 21
2019 6
2020 0
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302 results
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Page 1
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
Shalapour S, et al. Nature 2017. PMID 29144460 Free PMC article.
Whereas CD8(+) T-cell ablation accelerates hepatocellular carcinoma, genetic or pharmacological interference with IgA(+) cell generation attenuates liver carcinogenesis and induces cytotoxic T-lymphocyte-mediated regression of established hepatocellular carcinoma. These findings establish the importance of inflammation-induced suppression of cytotoxic CD8(+) T-lymphocyte activation as a tumour-promoting mechanism....
Whereas CD8(+) T-cell ablation accelerates hepatocellular carcinoma, genetic or pharmacological interference with IgA(+) cell generat …
Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy.
Stoiber S, et al. Cells 2019 - Review. PMID 31108883 Free PMC article.
Among these, chimeric antigen receptor (CAR) T cells have shown unparalleled therapeutic potential in treating refractory hematological malignancies. ...
Among these, chimeric antigen receptor (CAR) T cells have shown unparalleled therapeutic potential in treating refractory hematologic …
Cloning and expansion of antigen-specific T cells using iPS cell technology: development of "off-the-shelf" T cells for the use in allogeneic transfusion settings.
Kawamoto H, et al. Int J Hematol 2018 - Review. PMID 29388165
This strategy is based on the idea that when iPSCs are produced from antigen-specific CTLs, CTLs regenerated from such iPSCs should show the same antigen specificity as the original CTLs. ...As a first-in-human trial, we are planning to apply our strategy to relapsed acute myeloid leukemia patients by targeting the WT1 antigen....
This strategy is based on the idea that when iPSCs are produced from antigen-specific CTLs, CTLs regenerated from such iPSCs should s …
Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs.
Lambolez F, et al. Immunol Rev 2007 - Review. PMID 17291288
Intraepithelial lymphocytes (IELs) contain several subsets, but the origin of the T-cell receptor (TCR)alphabeta(+) CD8 alpha alpha(+) IELs has been particularly controversial. ...TCR alpha beta(+) CD8 alpha alpha(+) IELs can differentiate in the intestine from each of these sources, but in normal euthymic mice, the thymus appears to be the major source for TCR alpha beta(+) CD8 alpha alpha(+) IELs. ...
Intraepithelial lymphocytes (IELs) contain several subsets, but the origin of the T-cell receptor (TCR)alphabeta(+) CD8 alpha
Development of TCR alpha beta CD8 alpha alpha intestinal intraepithelial lymphocytes is promoted by interleukin-15-producing epithelial cells constitutively stimulated by gram-negative bacteria via TLR4.
Kaneko M, et al. Biol Pharm Bull 2004. PMID 15187438 Free article.
The influence of microbes and lipopolysaccharides on the development of i-IEL, especially the TCR alpha beta(+) CD8 alpha alpha subset, was investigated using the different TLR4-mutant mouse strains C3H/HeJ, BALB/lps(d), and C57BL/10ScCr. ...Our findings suggest that LPS induces IL-15 production by i-EC, resulting in the development of TCR alpha beta CD8 alpha alpha i-IEL....
The influence of microbes and lipopolysaccharides on the development of i-IEL, especially the TCR alpha beta(+) CD8 alpha
Differential capacity of CD8+ alpha or CD8- alpha dendritic cell subsets to prime for eosinophilic airway inflammation in the T-helper type 2-prone milieu of the lung.
Hammad H, et al. Clin Exp Allergy 2004. PMID 15663556
CD8 alpha(-) DCs have been shown to preferentially induce Th type 2 (Th2) responses whereas CD8 alpha(+) DCs induce Th1 responses. ...CONCLUSION: CD8 alpha(-) DCs are superior compared with CD8 alpha(+) DCs in inducing Th2 responses and eosinophilic airway inflammation in the Th2-prone environment of the lung....
CD8 alpha(-) DCs have been shown to preferentially induce Th type 2 (Th2) responses whereas CD8 alpha(+) DCs ind
Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells
Lau CM, et al. J Exp Med 2018. PMID 30087163 Free PMC article.
An IRF8-dependent subset of conventional dendritic cells (cDCs), termed cDC1, effectively cross-primes CD8(+) T cells and facilitates tumor-specific T cell responses. ...Accordingly, DC-specific Etv6 deletion impaired CD8(+) T cell cross-priming and the generation of tumor antigen-specific CD8(+) T cells. ...
An IRF8-dependent subset of conventional dendritic cells (cDCs), termed cDC1, effectively cross-primes CD8(+) T cells and facilitates …
Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domains.
Alabanza L, et al. Mol Ther 2017. PMID 28807568 Free PMC article.
Anti-CD19 chimeric antigen receptor (CAR) T cells have caused remissions of B cell malignancies, but problems including cytokine-mediated toxicity and short persistence of CAR T cells in vivo might limit the effectiveness of anti-CD19 CAR T cells. Anti-CD19 CARs that have been tested clinically had single-chain variable fragments (scFvs) derived from murine antibodies. We have designed and constructed novel anti-CD19 CARs containing a scFv with fully human variable regions. ...
Anti-CD19 chimeric antigen receptor (CAR) T cells have caused remissions of B cell malignancies, but problems including cytokine-medi …
302 results
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